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ketogenesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
acetoacetyl-CoA + H2O + acetyl-CoA <=> H+ + CoA + (S)-3-hydroxy-3-methylglutaryl-CoA 2.3.3.10 hydroxymethylglutaryl-CoA synthase

(S)-3-hydroxy-3-methylglutaryl-CoA <=> acetoacetate + acetyl-CoA 4.1.3.4 hydroxymethylglutaryl-CoA lyase

acetoacetate + H+ <=> acetone + CO2 1.8.1.5 2-oxopropyl-CoM reductase (carboxylating)
4.1.1.4 acetoacetate decarboxylase


acetyl-CoA <=> acetoacetyl-CoA + CoA 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH)
2.3.1.155 acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.38 [acyl-carrier-protein] S-acetyltransferase
2.3.1.9 acetyl-CoA C-acetyltransferase





(R)-3-hydroxybutanoate + NAD+ <=> acetoacetate + NADH + H+ 1.1.1.30 3-hydroxybutyrate dehydrogenase

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