Copied!

Pathway Search



folate transformations III (E. coli)

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
5,10-methenyltetrahydrofolate + H2O <=> 10-formyltetrahydrofolate + H+ 3.5.4.9 methenyltetrahydrofolate cyclohydrolase

L-serine + tetrahydrofolate <=> glycine + 5,10-methylenetetrahydrofolate + H2O 2.1.2.1 glycine hydroxymethyltransferase

5-formyltetrahydrofolate + ATP <=> 5,10-methenyltetrahydrofolate + ADP + phosphate 6.3.3.2 5-formyltetrahydrofolate cyclo-ligase

glycine + tetrahydrofolate + NAD+ <=> 5,10-methylenetetrahydrofolate + NH3 + CO2 + NADH 1.4.1.f
1.4.4.2 glycine dehydrogenase (aminomethyl-transferring)
1.8.1.4 dihydrolipoyl dehydrogenase
2.1.2.10 aminomethyltransferase




tetrahydrofolate + NADP+ <=> 7,8-dihydrofolate + NADPH + H+ 1.5.1.3 dihydrofolate reductase
1.5.1.33 pteridine reductase
1.5.1.34 6,7-dihydropteridine reductase
1.5.1.50 dihydromonapterin reductase




5,10-methylenetetrahydrofolate + dUMP <=> dTMP + 7,8-dihydrofolate 2.1.1.45 thymidylate synthase

5-methyltetrahydrofolate + NAD+ <=> 5,10-methylenetetrahydrofolate + H+ + NADH 1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H]

5,10-methylenetetrahydrofolate + NADP+ <=> 5,10-methenyltetrahydrofolate + NADPH 1.5.1.15 methylenetetrahydrofolate dehydrogenase (NAD+)
1.5.1.5 methylenetetrahydrofolate dehydrogenase (NADP+)


L-homocysteine + 5-methyltetrahydrofolate <=> L-methionine + tetrahydrofolate 2.1.1.13 methionine synthase
2.1.1.14 5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase


Visualization of the pathway