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ceramide degradation by alpha-oxidation

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
odd_numbered_straight_chain_2,3,4-saturated_fatty_aldehyde + NAD+ + H2O <=> odd_numbered_straight_chain_2,3,4-saturated_fatty_acid + NADH + H+ 1.2.1.3 aldehyde dehydrogenase (NAD+)

(2R)-2-hydroxy_even_numbered_straight_chain_2,3,4-saturated_fatty_acid + ATP + CoA <=> (R)-2-hydroxy_even_numbered_straight_chain_2,3,4-saturated_fatty_acyl_CoA + AMP + diphosphate 6.2.1

phytoceramide + O2 + ferricytochrome_b5 + H+ <=> (2''R)-2''-hydroxy-phytoceramide + H2O + ferricytochrome_b5 1.14.18.6 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase

odd_numbered_straight_chain_2,3,4-saturated_fatty_acid + ATP + CoA <=> odd_numbered_straight_chain_2,3,4-saturated_fatty_acyl_CoA + AMP + diphosphate 6.2.1.3 long-chain-fatty-acid---CoA ligase

(R)-2-hydroxy_even_numbered_straight_chain_2,3,4-saturated_fatty_acyl_CoA <=> odd_numbered_straight_chain_2,3,4-saturated_fatty_aldehyde + formyl-CoA 4.1.2

(2''R)-2''-hydroxy-phytoceramide + H2O <=> phytosphingosine + (2R)-2-hydroxy_even_numbered_straight_chain_2,3,4-saturated_fatty_acid 3.5.1.23 ceramidase

H2O + formyl-CoA <=> H+ + formate + CoA 3.1.2.10 formyl-CoA hydrolase

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