|
|
5-Pregnene-3,20-dione <=> progesterone
|
5.3.3.1
steroid Delta-isomerase
|
–
|
| |
BRENDA:
BS1077
MetaCyc:
RXN66-354
|
|
|
|
pregnenolone + NAD+ <=> 5-Pregnene-3,20-dione + NADH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
–
|
| |
BRENDA:
BS257030-a
MetaCyc:
RXN66-353
|
|
|
|
pregnenolone + reduced_[NADPH-hemoprotein_reductase] + O2 <=> 17alpha-hydroxypregnenolone + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
|
–
|
| |
MetaCyc:
RXN66-340
|
|
|
|
5alpha-Androstane-3beta,17beta-diol + NADP+ <=> 5alpha-dihydrotestosterone + NADPH + H+
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.184
carbonyl reductase (NADPH)
1.1.1.210
3beta(or 20alpha)-hydroxysteroid dehydrogenase
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
–
–
–
–
–
–
|
| |
BRENDA:
BR29254
KEGG:
R04344
MetaCyc:
1.1.1.210-RXN
SABIO-RK:
7050;
8080
|
|
|
|
progesterone + O2 + reduced_[NADPH-hemoprotein_reductase] <=> 17alpha-hydroxyprogesterone + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
|
–
|
| |
MetaCyc:
RXN66-355
|
|
|
|
pregn-5-ene-3,20-dione-17-ol <=> 17alpha-hydroxyprogesterone
|
5.3.3.1
steroid Delta-isomerase
|
–
|
| |
MetaCyc:
RXN66-351
|
|
|
|
17alpha-hydroxypregnenolone + NAD+ <=> NADH + H+ + pregn-5-ene-3,20-dione-17-ol
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
|
–
|
| |
MetaCyc:
RXN66-350
|
|
