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arachidonate biosynthesis III (6-desaturase, mammals)

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
8,11,14-eicosatrienoic_acid + O2 + ferricytochrome_b5 + H+ <=> Arachidonoyl-CoA + H2O + ferricytochrome_b5 1.14.19.44 acyl-CoA (8-3)-desaturase

3-oxodihomo_gamma-linolenoyl-CoA + NADPH + H+ <=> (3R)-hydroxydihomo_gamma-linolenoyl-CoA + NADP+ 1.1.1.330 very-long-chain 3-oxoacyl-CoA reductase

(2E,8Z,11Z,14Z)-icosatetraenoyl-CoA + NADH + H+ <=> 8,11,14-eicosatrienoic_acid + NAD+ 1.3.1.93 very-long-chain enoyl-CoA reductase

malonyl-CoA + gamma-linolenoyl-CoA + H+ <=> 3-oxodihomo_gamma-linolenoyl-CoA + CoA + CO2 2.3.1

(3R)-hydroxydihomo_gamma-linolenoyl-CoA <=> (2E,8Z,11Z,14Z)-icosatetraenoyl-CoA + H2O 4.2.1.134 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase

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