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Terpenoid backbone biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
n isopentenyl_diphosphate <=> cis-1,4-polyisoprene + n diphosphate 2.5.1.20 rubber cis-polyprenylcistransferase
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NADP+ + CoA + (R)-mevalonate <=> H+ + NADPH + (S)-3-hydroxy-3-methylglutaryl-CoA 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH)
1.1.1.88 hydroxymethylglutaryl-CoA reductase
1.1.1.B38
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–
–
dimethylallyl_diphosphate + oxidized_ferredoxin + H2O <=> (E)-4-hydroxy-3-methylbut-2-en-1-yl_diphosphate + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.17.7.4 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase
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geranyl_diphosphate + isopentenyl_diphosphate <=> nonaprenyl_diphosphate + diphosphate 2.5.1.84 all-trans-nonaprenyl diphosphate synthase [geranyl-diphosphate specific]
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2-C-methyl-D-erythritol_4-phosphate + NADP+ <=> 1-deoxy-D-xylulose_5-phosphate + NADPH + H+ 1.1.1.267 1-deoxy-D-xylulose-5-phosphate reductoisomerase
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ATP + (R)-5-phosphomevalonate <=> ADP + phosphate + isopentenyl_phosphate + CO2 4.1.1.99 phosphomevalonate decarboxylase
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geranyl_diphosphate + isopentenyl_diphosphate <=> (2E,6E)-farnesyl_diphosphate + diphosphate 2.5.1.1 dimethylallyltranstransferase
2.5.1.10 (2E,6E)-farnesyl diphosphate synthase
2.5.1.29 geranylgeranyl diphosphate synthase
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–
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4-(cytidine_5''-diphospho)-2-C-methyl-D-erythritol + ATP <=> H+ + 2-phospho-4-(cytidine_5''-diphospho)-2-C-methyl-D-erythritol + ADP 2.7.1.148 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
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CTP + (2E,6E)-farnesol <=> CDP + farnesyl_phosphate + H+ 2.7.1.216 farnesol kinase
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5-diphosphomevalonate + ATP <=> isopentenyl_diphosphate + CO2 + ADP + phosphate 4.1.1.33 diphosphomevalonate decarboxylase
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protein_C-terminal_S-farnesyl-L-cysteine + methanol <=> protein_C-terminal_S-farnesyl-L-cysteine_methyl_ester + H2O 3.1.1
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(R)-mevalonate + ATP <=> H+ + (R)-5-phosphomevalonate + ADP 2.7.1.36 mevalonate kinase
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S-adenosyl-L-methionine + protein_C-terminal_S-farnesyl-L-cysteine <=> S-adenosyl-L-homocysteine + protein_C-terminal_S-farnesyl-L-cysteine_methyl_ester 2.1.1.100 protein-S-isoprenylcysteine O-methyltransferase
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S-(2E,6E)-farnesyl-L-cysteine + O2 + H2O <=> (2E,6E)-farnesal + L-cysteine + H2O2 1.8.3.5 prenylcysteine oxidase
1.8.3.6 farnesylcysteine lyase
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acetoacetyl-CoA + H2O + acetyl-CoA <=> H+ + CoA + (S)-3-hydroxy-3-methylglutaryl-CoA 2.3.3.10 hydroxymethylglutaryl-CoA synthase
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(R)-3-phosphomevalonate + ATP <=> 3,5-diphosphomevalonate + ADP + H+ 2.7.1.186 mevalonate-3-phosphate 5-kinase
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(2Z,6E)-farnesyl_diphosphate + n isopentenyl_diphosphate <=> n diphosphate + trans,poly-cis-polyprenyl_diphosphate 2.5.1.88 trans,polycis-polyprenyl diphosphate synthase [(2Z,6E)-farnesyl diphosphate specific]
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S-farnesyl_protein + H2O <=> protein_C-terminal_S-farnesyl-L-cysteine + peptide 3.4.22
3.4.24.84 Ste24 endopeptidase
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protein_C-terminal_S-farnesyl-L-cysteine_methyl_ester <=> S-(2E,6E)-farnesyl-L-cysteine not assigned
 –
(2E,6E)-farnesyl_diphosphate + isopentenyl_diphosphate <=> octaprenyl_diphosphate + diphosphate 2.5.1.90 all-trans-octaprenyl-diphosphate synthase
2.5.1.91 all-trans-decaprenyl-diphosphate synthase
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(E)-4-hydroxy-3-methylbut-2-en-1-yl_diphosphate + oxidized_ferredoxin + H2O <=> 2-C-methyl-D-erythritol_2,4-cyclodiphosphate + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.17.7.1 (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin)
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(2E,6E)-farnesyl_diphosphate + isopentenyl_diphosphate <=> all-trans-heptaprenyl_diphosphate + diphosphate 2.5.1.30 heptaprenyl diphosphate synthase
2.5.1.B41
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H+ + pyruvate + D-glyceraldehyde_3-phosphate <=> 1-deoxy-D-xylulose_5-phosphate + CO2 2.2.1.7 1-deoxy-D-xylulose-5-phosphate synthase
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geranylgeranyl_diphosphate + isopentenyl_diphosphate <=> nonaprenyl_diphosphate + diphosphate 2.5.1.84 all-trans-nonaprenyl diphosphate synthase [geranyl-diphosphate specific]
2.5.1.85 all-trans-nonaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]
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(R)-5-phosphomevalonate + ATP <=> 5-diphosphomevalonate + ADP 2.7.4.2 phosphomevalonate kinase
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(2E,6E)-farnesol + NAD+ <=> (2E,6E)-farnesal + NADH + H+ 1.1.1.347 geraniol dehydrogenase (NAD+)
1.1.1.354 farnesol dehydrogenase (NAD+)
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isopentenyl_diphosphate <=> dimethylallyl_diphosphate 5.3.3.2 isopentenyl-diphosphate Delta-isomerase
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(E)-4-hydroxy-3-methylbut-2-en-1-yl_diphosphate + flavin + H2O + H+ <=> 2-C-methyl-D-erythritol_2,4-cyclodiphosphate + reduced_flavodoxin 1.17.7.3 (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)
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isopentenyl_diphosphate + oxidized_ferredoxin + H2O <=> (E)-4-hydroxy-3-methylbut-2-en-1-yl_diphosphate + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.17.7.4 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase
–
(2E,6E)-farnesyl_diphosphate + isopentenyl_diphosphate <=> geranylgeranyl_diphosphate + diphosphate 2.5.1
2.5.1.29 geranylgeranyl diphosphate synthase
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geranyl_diphosphate + isopentenyl_diphosphate <=> diphosphate + (2Z,6E)-farnesyl_diphosphate 2.5.1.68 (2Z,6E)-farnesyl diphosphate synthase
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geranylgeranyl_diphosphate + isopentenyl_diphosphate <=> tritrans,heptacis-undecaprenyl_diphosphate + diphosphate 2.5.1.89 tritrans,polycis-undecaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]
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phytyl_diphosphate + NADP+ <=> geranylgeranyl_diphosphate + NADPH + H+ 1.3.1.83 geranylgeranyl diphosphate reductase
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(2Z,6E)-farnesyl_diphosphate + isopentenyl_diphosphate <=> (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl_diphosphate + diphosphate 2.5.1.86 trans,polycis-decaprenyl diphosphate synthase
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(R)-mevalonate + ATP <=> (R)-3-phosphomevalonate + ADP + H+ 2.7.1.185 mevalonate 3-kinase
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H+ + 2-C-methyl-D-erythritol_4-phosphate + CTP <=> 4-(cytidine_5''-diphospho)-2-C-methyl-D-erythritol + diphosphate 2.7.7.60 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
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farnesyl_phosphate + CTP <=> (2E,6E)-farnesyl_diphosphate + CDP 2.7.4.32 farnesyl phosphate kinase
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(R)-mevalonate + NAD+ + CoA <=> (S)-3-hydroxy-3-methylglutaryl-CoA + NADH + H+ 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH)
1.1.1.88 hydroxymethylglutaryl-CoA reductase
1.1.1.B38
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–
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2-phospho-4-(cytidine_5''-diphospho)-2-C-methyl-D-erythritol <=> 2-C-methyl-D-erythritol_2,4-cyclodiphosphate + CMP 4.6.1.12 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
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dimethylallyl_diphosphate + isopentenyl_diphosphate <=> diphosphate + (2Z,6Z)-farnesyl_diphosphate 2.5.1.92 (2Z,6Z)-farnesyl diphosphate synthase
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acetyl-CoA <=> acetoacetyl-CoA + CoA 1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH)
2.3.1.155 acetyl-CoA C-myristoyltransferase
2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.38 [acyl-carrier-protein] S-acetyltransferase
2.3.1.9 acetyl-CoA C-acetyltransferase
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–
–
–
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(2E,6E)-farnesyl_diphosphate + protein <=> S-farnesyl_protein + diphosphate 2.5.1.58 protein farnesyltransferase
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3,5-diphosphomevalonate + H+ <=> isopentenyl_phosphate + CO2 + phosphate 4.1.1.110 bisphosphomevalonate decarboxylase
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dimethylallyl_diphosphate + isopentenyl_diphosphate <=> geranyl_diphosphate + diphosphate 2.5.1.1 dimethylallyltranstransferase
2.5.1.10 (2E,6E)-farnesyl diphosphate synthase
2.5.1.29 geranylgeranyl diphosphate synthase
2.5.1.67 chrysanthemyl diphosphate synthase
2.5.1.69 lavandulyl diphosphate synthase
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(2E,6E)-farnesyl_diphosphate + isopentenyl_diphosphate <=> undecaprenyl_diphosphate + diphosphate 2.5.1.31 ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]
2.5.1.M1
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(2E,6E)-farnesyl_diphosphate + isopentenyl_diphosphate <=> di-trans-poly-cis-decaprenyl_diphosphate + diphosphate 2.5.1.87 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]
2.5.1.91 all-trans-decaprenyl-diphosphate synthase
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(2E,6E)-farnesyl_diphosphate + H2O <=> (2E,6E)-farnesol + diphosphate 3.1.7.6 farnesyl diphosphatase
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geranylgeranyl_diphosphate + isopentenyl_diphosphate <=> all-trans-hexaprenyl_diphosphate + diphosphate 2.5.1.82 hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]
2.5.1.B41
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(2E,6E)-farnesyl_diphosphate + isopentenyl_diphosphate <=> all-trans-hexaprenyl_diphosphate + diphosphate 2.5.1.82 hexaprenyl diphosphate synthase [geranylgeranyl-diphosphate specific]
2.5.1.83 hexaprenyl diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]
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dimethylallyl_diphosphate <=> isoprene + diphosphate 4.2.3.27 isoprene synthase
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isopentenyl_phosphate + ATP <=> isopentenyl_diphosphate + ADP 2.7.4.26 isopentenyl phosphate kinase
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(2E,6E)-farnesyl_diphosphate + n isopentenyl_diphosphate <=> n diphosphate + di-trans,poly-cis-polyprenyl_diphosphate 2.5.1.87 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific]
2.5.1.88 trans,polycis-polyprenyl diphosphate synthase [(2Z,6E)-farnesyl diphosphate specific]
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(2E,6E)-farnesol + NADP+ <=> (2E,6E)-farnesal + NADPH + H+ 1.1.1.21 aldose reductase
1.1.1.216 farnesol dehydrogenase (NADP+)
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Visualization of the pathway