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NAD salvage pathway V (PNC V cycle)

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
nicotinamide + H2O <=> NH3 + nicotinate 3.5.1.13 aryl-acylamidase
3.5.1.19 nicotinamidase
3.5.1.4 amidase



nicotinic_acid_mononucleotide + ATP + H+ <=> deamido-NAD+ + diphosphate 2.7.7.1 nicotinamide-nucleotide adenylyltransferase
2.7.7.18 nicotinate-nucleotide adenylyltransferase


nicotinate + 5-phospho-alpha-D-ribose_1-diphosphate + ATP + H2O <=> nicotinic_acid_mononucleotide + diphosphate + ADP + phosphate 6.3.4.21 nicotinate phosphoribosyltransferase

[histone]-N6-acetyl-L-lysine + NAD+ + H2O <=> [histone]-L-lysine + 2''''-O-acetyl-ADP-ribose + nicotinamide 2.3.1.286 protein acetyllysine N-acetyltransferase

ATP + deamido-NAD+ + L-glutamine + H2O <=> H+ + L-glutamate + AMP + diphosphate + NAD+ 6.3.1.5 NAD+ synthase
6.3.5.1 NAD+ synthase (glutamine-hydrolysing)


Visualization of the pathway