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(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
(3S,6Z,9Z,12Z,15Z,18Z)-3-hydroxytetracosapentaenoyl-CoA <=> (2E,6Z,9Z,12Z,15Z,18Z)-Tetracosahexaenoyl-CoA + H2O 4.2.1.17 enoyl-CoA hydratase

(4Z,7Z,10Z,13Z,16Z)-Docosapentaenoyl-CoA + acetyl-CoA <=> (6Z,9Z,12Z,15Z,18Z)-3-Oxotetracosapentaenoyl-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase
2.3.1.176 propanoyl-CoA C-acyltransferase


(9Z,12Z,15Z,18Z)-Tetracosatetraenoyl-CoA + NADP+ <=> (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + NADPH + H+ 1.3.1.93 very-long-chain enoyl-CoA reductase

(3R,7Z,10Z,13Z,16Z)-3-hydroxydocosatetraenoyl-CoA <=> (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + H2O 4.2.1.134 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase

malonyl-CoA + Arachidonoyl-CoA + H+ <=> (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + CoA + CO2 2.3.1

(7Z,10Z,13Z,16Z)-Docosatetraenoyl-CoA + NADP+ <=> (2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + NADPH + H+ 1.3.1.93 very-long-chain enoyl-CoA reductase

(3R,7Z,10Z,13Z,16Z)-3-hydroxydocosatetraenoyl-CoA + NADP+ <=> (7Z,10Z,13Z,16Z)-3-oxodocosatetraenoyl-CoA + NADPH + H+ 1.1.1.330 very-long-chain 3-oxoacyl-CoA reductase

(6Z,9Z,12Z,15Z,18Z)-Tetracosapentaenoyl-CoA + O2 <=> (2E,6Z,9Z,12Z,15Z,18Z)-Tetracosahexaenoyl-CoA + H2O2 1.3.3.6 acyl-CoA oxidase

malonyl-CoA + (7Z,10Z,13Z,16Z)-Docosatetraenoyl-CoA + H+ <=> (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + CoA + CO2 2.3.1

(9Z,12Z,15Z,18Z)-Tetracosatetraenoyl-CoA + O2 + ferricytochrome_b5 + H+ <=> (6Z,9Z,12Z,15Z,18Z)-Tetracosapentaenoyl-CoA + H2O + ferricytochrome_b5 1.14.19.3 acyl-CoA 6-desaturase

(3R,9Z,12Z,15Z,18Z)-3-hydroxytetracosatetraenoyl-CoA <=> (2E,9Z,12Z,15Z,18Z)-tetracosapentaenoyl-CoA + H2O 4.2.1.134 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase

(3S,6Z,9Z,12Z,15Z,18Z)-3-hydroxytetracosapentaenoyl-CoA + NAD+ <=> (6Z,9Z,12Z,15Z,18Z)-3-Oxotetracosapentaenoyl-CoA + NADH + H+ 1.1.1

(3R,9Z,12Z,15Z,18Z)-3-hydroxytetracosatetraenoyl-CoA + NADP+ <=> (9Z,12Z,15Z,18Z)-3-oxotetracosatetraenoyl-CoA + NADPH + H+ 1.1.1.330 very-long-chain 3-oxoacyl-CoA reductase

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