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Your translated search: 4-methyl-2-oxopentanoate = 100 reactions were found.
State Icon Reaction EC-Number Conf. maximal confidence score from EnzymeDetector PW
L-leucine + NAD+ + H2O <=> H+ + NH3 + NADH + 4-methyl-2-oxopentanoate 1.4.1.1 alanine dehydrogenase
1.4.1.20 phenylalanine dehydrogenase
1.4.1.23 valine dehydrogenase (NAD+)
1.4.1.8 valine dehydrogenase (NADP+)
1.4.1.9 leucine dehydrogenase





L-leucine + 2-oxoglutarate <=> L-glutamate + 4-methyl-2-oxopentanoate 2.6.1.1 aspartate transaminase
2.6.1.2 alanine transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.6 leucine transaminase
2.6.1.67 2-aminohexanoate transaminase
2.6.1.9 histidinol-phosphate transaminase








H+ + (2S)-2-isopropyl-3-oxosuccinate <=> 4-methyl-2-oxopentanoate + CO2 0.0.0.0
1.1.1.85 3-isopropylmalate dehydrogenase


4-methyl-2-oxopentanoate + CoA + NAD+ <=> isovaleryl-CoA + CO2 + NADH 1.2.1.25 2-oxoisovalerate dehydrogenase (acylating)
1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)


(2R,3S)-3-isopropylmalate + NAD+ <=> 4-methyl-2-oxopentanoate + CO2 + NADH 1.1.1.286 isocitrate---homoisocitrate dehydrogenase
1.1.1.85 3-isopropylmalate dehydrogenase


4-methyl-2-oxopentanoate + CoA + oxidized_ferredoxin <=> isovaleryl-CoA + CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.2.7.7 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
1.2.7.8 indolepyruvate ferredoxin oxidoreductase


4-methyl-2-oxopentanoate + H+ <=> Isovaleraldehyde + CO2 4.1.1.1 pyruvate decarboxylase
4.1.1.7 benzoylformate decarboxylase
4.1.1.72 branched-chain-2-oxoacid decarboxylase



(R)-2-hydroxyisocaproate + NADP+ <=> 4-methyl-2-oxopentanoate + NADPH + H+ 1.1.1.272 D-2-hydroxyacid dehydrogenase (NADP+)

(R)-2-hydroxyisocaproate + NAD+ <=> 4-methyl-2-oxopentanoate + NADH + H+ 1.1.1.272 D-2-hydroxyacid dehydrogenase (NADP+)
1.1.1.345 D-2-hydroxyacid dehydrogenase (NAD+)


4-methyl-2-oxopentanoate + NADH <=> 2-hydroxyisocaproate + NAD+ 1.1.1.27 L-lactate dehydrogenase
1.1.1.272 D-2-hydroxyacid dehydrogenase (NADP+)
1.1.1.28 D-lactate dehydrogenase
1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.345 D-2-hydroxyacid dehydrogenase (NAD+)
1.1.1.37 malate dehydrogenase






L-2-Hydroxyisocaproate + O2 <=> 4-methyl-2-oxopentanoate + H2O2 1.1.3.15 (S)-2-hydroxy-acid oxidase

L-leucine + O2 + H2O <=> 4-methyl-2-oxopentanoate + NH3 + H2O2 1.4.3.14 L-lysine oxidase
1.4.3.2 L-amino-acid oxidase


D-Leu + H2O + O2 <=> 4-methyl-2-oxopentanoate + NH3 + H2O2 1.4.3.3 D-amino-acid oxidase

pyruvate + L-leucine <=> L-alanine + 4-methyl-2-oxopentanoate 2.6.1.12 alanine---oxo-acid transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.51 serine---pyruvate transaminase
2.6.1.84 arginine---pyruvate transaminase
2.6.1.9 histidinol-phosphate transaminase





L-leucine + glyoxylate <=> 4-methyl-2-oxopentanoate + glycine 2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.44 alanine---glyoxylate transaminase
2.6.1.60 aromatic-amino-acid---glyoxylate transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase




L-leucine + 2-oxoisovalerate <=> 4-methyl-2-oxopentanoate + L-valine 2.6.1.42 branched-chain-amino-acid transaminase

L-methionine + 4-methyl-2-oxopentanoate <=> 4-methylsulfanyl-2-oxobutanoate + L-leucine 2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.88 methionine transaminase


penicillin_G + 4-methyl-2-oxopentanoate + O2 <=> phenylacetyl-7-aminodeacetoxycephalosporanic_acid + Isovalerate + CO2 + H2O 1.14.20.1 deacetoxycephalosporin-C synthase

4-methyl-2-oxopentanoate + Enzyme_N6-(lipoyl)lysine <=> [dihydrolipoyllysine-residue_(2-methylpropanoyl)transferase]_S-(3-methylbutanoyl)dihydrolipoyllysine + CO2 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)

4-methyl-2-oxopentanoate + thiamine_diphosphate <=> 3-Methyl-1-hydroxybutyl-ThPP + CO2 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)

4-methyl-2-oxopentanoate + [apo_BCAA_dehydrogenase_E2_protein]_N6-lipoyl-L-lysine + H+ <=> [apo_BCAA_dehydrogenase_E2_protein]_N6-S-[3-methylbutanoyl]dihydrolipoyl-L-lysine + CO2 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)

4-methyl-2-oxopentanoate + O2 <=> 3-Hydroxy-3-methylbutyrate + CO2 1.13.11

L-leucine + 3-Indole-2-oxopropanoate <=> 4-methyl-2-oxopentanoate + L-tryptophan 2.6.1.28 tryptophan---phenylpyruvate transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.99 L-tryptophan---pyruvate aminotransferase



L-leucine + 4-hydroxyphenylpyruvate <=> 4-methyl-2-oxopentanoate + L-tyrosine 2.6.1.42 branched-chain-amino-acid transaminase

L-leucine + 4-methyl-2-oxopentanoate <=> 4-methyl-2-oxopentanoate + L-leucine 2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.6 leucine transaminase


DL-leucine + H2O + O2 <=> 4-methyl-2-oxopentanoate + NH3 + H2O2 1.4.3.2 L-amino-acid oxidase

2-hydroxyisocaproate + H2O + O2 <=> 4-methyl-2-oxopentanoate + NH3 + H2O2 1.4.3.2 L-amino-acid oxidase

D-Leu + H2O + 2,6-dichlorophenolindophenol <=> 4-methyl-2-oxopentanoate + NH3 + reduced_2,6-dichlorophenolindophenol 1.4.99.6 D-arginine dehydrogenase

L-leucine + H2O + 3-acetylpyridine-deamino-NAD+ <=> 4-methyl-2-oxopentanoate + NH3 + 3-acetylpyridine_hypoxanthine_nucleotide 1.4.1.9 leucine dehydrogenase

L-leucine + H2O + 3-acetylpyridine_adenine_dinucleotide <=> 4-methyl-2-oxopentanoate + NH3 + reduced_acetylpyridine_adenine_dinucleotide 1.4.1.9 leucine dehydrogenase

L-leucine + H2O + deamido-NAD+ <=> 4-methyl-2-oxopentanoate + NH3 + deamino-NADH 1.4.1.9 leucine dehydrogenase

L-leucine + H2O + thio-NAD+ <=> 4-methyl-2-oxopentanoate + NH3 + thio-NADH 1.4.1.9 leucine dehydrogenase

L-leucine + H2O + 3-pyridinealdehyde-NAD+ <=> 4-methyl-2-oxopentanoate + NH3 + 3-pyridinealdehyde-NAD+ 1.4.1.9 leucine dehydrogenase

L-leucine + H2O + 2 cytochrome_b <=> 4-methyl-2-oxopentanoate + NH3 + 2 reduced_cytochrome_b 1.4.99.B3

D-Leu + oxidized_acceptor + H2O <=> 4-methyl-2-oxopentanoate + NH3 + reduced_acceptor 1.4.5.1 D-amino acid dehydrogenase (quinone)

4-methyl-2-oxopentanoate + CoA + Oxidized_benzyl_viologen <=> isovaleryl-CoA + CO2 + reduced_benzyl_viologen 1.2.7.7 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)

ampicillin + 4-methyl-2-oxopentanoate + O2 <=> cephalexin + succinate + CO2 + H2O 1.14.20.1 deacetoxycephalosporin-C synthase

N-methyl-DL-Leu + H2O + O2 <=> 4-methyl-2-oxopentanoate + methylamine + H2O2 1.4.3.3 D-amino-acid oxidase

D-Leu + H2O + O2 <=> 4-methyl-2-oxopentanoate + H2O2 1.4.3.19 glycine oxidase

(R)-2-hydroxyisocaproate + O2 <=> 4-methyl-2-oxopentanoate + H2O2 1.1.3.15 (S)-2-hydroxy-acid oxidase

2-hydroxyisocaproate + O2 <=> 4-methyl-2-oxopentanoate + H2O2 1.1.3.15 (S)-2-hydroxy-acid oxidase

L-leucine + 2-oxobutyrate <=> 4-methyl-2-oxopentanoate + L-valine 2.6.1.42 branched-chain-amino-acid transaminase

L-2-Hydroxyisocaproate + 2,6-dichlorophenolindophenol <=> 4-methyl-2-oxopentanoate + reduced_2,6-dichlorophenolindophenol 1.1.3.15 (S)-2-hydroxy-acid oxidase

2-oxosuccinamic_acid + L-leucine <=> L-asparagine + 4-methyl-2-oxopentanoate 2.6.1.14 asparagine---oxo-acid transaminase
2.6.1.9 histidinol-phosphate transaminase


L-asparagine + 4-methyl-2-oxopentanoate <=> 2-oxosuccinamic_acid + DL-leucine 2.6.1.14 asparagine---oxo-acid transaminase

L-leucine + 3-methyl-2-oxopentanoate <=> 4-methyl-2-oxopentanoate + L-isoleucine 2.6.1.42 branched-chain-amino-acid transaminase

L-isoleucine + 2-oxoisovalerate <=> 4-methyl-2-oxopentanoate + L-valine 2.6.1.42 branched-chain-amino-acid transaminase

L-isoleucine + 3-methyl-2-oxopentanoate <=> 4-methyl-2-oxopentanoate + L-isoleucine 2.6.1.42 branched-chain-amino-acid transaminase

D-Leu + 2-oxoglutarate <=> 4-methyl-2-oxopentanoate + D-glutamate 2.6.1.21 D-amino-acid transaminase

4-methyl-2-oxopentanoate + reduced_methyl_viologen <=> 2-hydroxyisocaproate + methyl_viologen 1.1.99.30 2-oxo-acid reductase

L-kynurenine + 4-methyl-2-oxopentanoate <=> Kynurenic_acid + DL-leucine + H2O 2.6.1.7 kynurenine---oxoglutarate transaminase

L-kynurenine + 4-methyl-2-oxopentanoate <=> Kynurenic_acid + 2,4-dimethylvalerate + H2O 2.6.1.7 kynurenine---oxoglutarate transaminase

L-kynurenine + 4-methyl-2-oxopentanoate <=> 4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine 2.6.1.7 kynurenine---oxoglutarate transaminase

DL-Ornithine + 2-oxoglutarate <=> L-glutamate + 4-methyl-2-oxopentanoate 2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase

(2R)-isobutyl-(3S)-methyl_malate <=> 4-methyl-2-oxopentanoate + propionate 4.1.3.1 isocitrate lyase

4-methyl-2-oxopentanoate + NH3 + NADH <=> DL-leucine + NAD+ + H2O 1.4.1.1 alanine dehydrogenase

4-methyl-2-oxopentanoate + NH3 + NADH <=> L-isoleucine + NAD+ + H2O 1.4.1.20 phenylalanine dehydrogenase
1.4.1.9 leucine dehydrogenase


4-methyl-2-oxopentanoate + NADH + H+ <=> L-2-Hydroxyisocaproate + NAD+ 1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.345 D-2-hydroxyacid dehydrogenase (NAD+)


beta-Alanine + 4-methyl-2-oxopentanoate <=> malonate_semialdehyde + L-isoleucine 2.6.1.18 beta-alanine---pyruvate transaminase

D-Leu + H2O + methylene_blue <=> 4-methyl-2-oxopentanoate + NH3 + reduced_methylene_blue 1.4.99.6 D-arginine dehydrogenase

4-methyl-2-oxopentanoate + reduced_benzyl_viologen <=> 2-hydroxyisocaproate + Oxidized_benzyl_viologen 1.1.99.30 2-oxo-acid reductase

L-leucine + oxaloacetate <=> 4-methyl-2-oxopentanoate + L-asparagine 2.6.1.42 branched-chain-amino-acid transaminase

L-norvaline + 4-methyl-2-oxopentanoate <=> 2-Oxopentanoate + L-leucine 2.6.1.42 branched-chain-amino-acid transaminase

L-2-aminobutanoate + 4-methyl-2-oxopentanoate <=> 2-oxobutyrate + L-leucine 2.6.1.42 branched-chain-amino-acid transaminase

L-allo-isoleucine + 4-methyl-2-oxopentanoate <=> 3-methyl-2-oxopentanoate + L-leucine 2.6.1.42 branched-chain-amino-acid transaminase

L-leucine + 2-oxobutyrate <=> 4-methyl-2-oxopentanoate + 2-aminobutanoate 2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase


L-isoleucine + 2-oxobutyrate <=> 4-methyl-2-oxopentanoate + 2-aminobutanoate 2.6.1.42 branched-chain-amino-acid transaminase

L-leucine + 2-oxooctanoate <=> 4-methyl-2-oxopentanoate + 2-aminooctanoate 2.6.1.42 branched-chain-amino-acid transaminase

L-isoleucine + 2-oxooctanoate <=> 4-methyl-2-oxopentanoate + 2-aminooctanoate 2.6.1.42 branched-chain-amino-acid transaminase

(R)-2-hydroxyisocaproate + 2-oxobutyrate <=> 4-methyl-2-oxopentanoate + D-2-hydroxybutyrate 1.1.99.30 2-oxo-acid reductase

4-methyl-2-oxopentanoate + [dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]-lipoyllysine <=> [dihydrolipoyllysine-residue_(2-methylpropanoyl)transferase]_S-(3-methylbutanoyl)dihydrolipoyllysine + CO2 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)

4-methyl-2-oxopentanoate + [dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]-lipoyllysine <=> [dihydrolipoyllysine-residue_(2-methylpropanoyl)transferase]_S-(2-methylbutanoyl)dihydrolipoyllysine + CO2 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)

L-leucine + 2-oxoisovalerate <=> 4-methyl-2-oxopentanoate + DL-valine 2.6.1.42 branched-chain-amino-acid transaminase

L-leucine + 2-Oxohexanoate <=> 4-methyl-2-oxopentanoate + 2-aminohexanoate 2.6.1.42 branched-chain-amino-acid transaminase

L-norleucine + 4-methyl-2-oxopentanoate <=> 2-Oxohexanoate + L-leucine 2.6.1.42 branched-chain-amino-acid transaminase

L-isoleucine + 2-Oxohexanoate <=> L-norleucine + 4-methyl-2-oxopentanoate 2.6.1.42 branched-chain-amino-acid transaminase

L-leucine + 2-Oxopentanoate <=> 4-methyl-2-oxopentanoate + 2-aminopentanoate 2.6.1.42 branched-chain-amino-acid transaminase

L-leucine + prephenate <=> 4-methyl-2-oxopentanoate + 1-(2-amino-2-carboxyethyl)-4-hydroxycyclohexa-2,5-diene-1-carboxylic_acid 2.6.1.42 branched-chain-amino-acid transaminase

4-methyl-2-oxopentanoate <=> Isobutyraldehyde + CO2 4.1.1.1 pyruvate decarboxylase
4.1.1.72 branched-chain-2-oxoacid decarboxylase


4-methyl-2-oxopentanoate <=> pentanal + CO2 4.1.1.72 branched-chain-2-oxoacid decarboxylase

4-methyl-2-oxopentanoate + NH3 + NADPH + H+ <=> D-Leu + H2O + NADP+ 1.4.99.6 D-arginine dehydrogenase

4-methyl-2-oxopentanoate + NADPH + H+ <=> 2-hydroxyisocaproate + NADP+ 1.1.1.79 glyoxylate reductase (NADP+)

4-methyl-2-oxopentanoate + NADPH + NH3 <=> L-norleucine + NADP+ + H2O 1.4.1.2 glutamate dehydrogenase

2-hydroxyisocaproate + acceptor <=> 4-methyl-2-oxopentanoate + reduced_acceptor 1.1.99.31 (S)-mandelate dehydrogenase

D-Leu + oxidized_2,6-dichlorophenolindophenol + H2O <=> 4-methyl-2-oxopentanoate + NH3 + reduced_2,6-dichlorophenolindophenol 1.5.99.13 D-proline dehydrogenase

(2R)-propyl-(3S)-methylmalate <=> 4-methyl-2-oxopentanoate + propionate 4.1.3.1 isocitrate lyase

L-leucine + 3-methylthio-2-oxobutanoate <=> 4-methyl-2-oxopentanoate + L-methionine 2.6.1.42 branched-chain-amino-acid transaminase

(2R,3S)-3-isopropylmalate + thio-NAD+ <=> 4-methyl-2-oxopentanoate + thio-NADH + CO2 1.1.1.85 3-isopropylmalate dehydrogenase

D-Leu + 2-oxoadipate <=> 4-methyl-2-oxopentanoate + 2-Aminoadipate 2.6.1.74 cephalosporin-C transaminase

L-aspartate + 4-methyl-2-oxopentanoate <=> oxaloacetate + L-leucine 2.6.1.1 aspartate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.6 leucine transaminase



L-isoleucine + oxaloacetate <=> 4-methyl-2-oxopentanoate + L-aspartate 2.6.1.42 branched-chain-amino-acid transaminase

L-isoleucine + glyoxylate <=> 4-methyl-2-oxopentanoate + glycine 2.6.1.42 branched-chain-amino-acid transaminase

L-glutamine + 4-methyl-2-oxopentanoate <=> 2-Oxoglutaramate + L-leucine 2.6.1.64 glutamine---phenylpyruvate transaminase

L-alanine + 4-methyl-2-oxopentanoate <=> pyruvate + DL-leucine 2.6.1.5 tyrosine transaminase

L-isoleucine + pyruvate <=> 4-methyl-2-oxopentanoate + L-alanine 2.6.1.42 branched-chain-amino-acid transaminase

L-phenylalanine + 4-methyl-2-oxopentanoate <=> phenylpyruvate + L-leucine 2.6.1.28 tryptophan---phenylpyruvate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.51 serine---pyruvate transaminase
2.6.1.64 glutamine---phenylpyruvate transaminase




phenylpyruvate + DL-leucine <=> L-phenylalanine + 4-methyl-2-oxopentanoate 2.6.1.28 tryptophan---phenylpyruvate transaminase

L-isoleucine + phenylpyruvate <=> 4-methyl-2-oxopentanoate + L-phenylalanine 2.6.1.42 branched-chain-amino-acid transaminase

2-hydroxyisocaproate + FMN <=> FMNH2 + 4-methyl-2-oxopentanoate 1.1.99.31 (S)-mandelate dehydrogenase

4-methyl-2-oxopentanoate + O2 + ampicillin <=> Isovalerate + CO2 + cephalexin + H2O 1.14.20.1 deacetoxycephalosporin-C synthase