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Your translated search: 2-oxoisovalerate = 80 reactions were found.
State Icon Reaction EC-Number Conf. maximal confidence score from EnzymeDetector PW
NAD+ + (R)-3,3-dimethylmalate <=> NADH + CO2 + 2-oxoisovalerate 1.1.1.84 dimethylmalate dehydrogenase

ketopantoate <=> formaldehyde + 2-oxoisovalerate 2.1.2.11 3-methyl-2-oxobutanoate hydroxymethyltransferase
4.1.2.12 2-dehydropantoate aldolase


2-oxoisovalerate + CoA + NAD+ <=> isobutyryl-CoA + CO2 + NADH 1.2.1.25 2-oxoisovalerate dehydrogenase (acylating)
1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)
1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
2.7.11.4 [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase




L-valine + H2O + NADP+ <=> 2-oxoisovalerate + NH3 + NADPH + H+ 1.4.1.23 valine dehydrogenase (NAD+)
1.4.1.3 glutamate dehydrogenase [NAD(P)+]
1.4.1.4 glutamate dehydrogenase (NADP+)
1.4.1.8 valine dehydrogenase (NADP+)




2-oxoisovalerate + acetyl-CoA + H2O <=> H+ + (2S)-2-isopropylmalate + CoA 2.3.3.13 2-isopropylmalate synthase
2.3.3.17 methylthioalkylmalate synthase


(S)-3-methyl-2-oxopentanoate + L-valine <=> L-isoleucine + 2-oxoisovalerate 2.6.1.32 valine---3-methyl-2-oxovalerate transaminase
2.6.1.42 branched-chain-amino-acid transaminase


pyruvate + L-valine <=> L-alanine + 2-oxoisovalerate 2.6.1.12 alanine---oxo-acid transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.51 serine---pyruvate transaminase
2.6.1.66 valine---pyruvate transaminase




2-oxoisovalerate + CoA + oxidized_ferredoxin <=> isobutyryl-CoA + CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.2.7.7 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)

L-valine + H2O + NAD+ <=> 2-oxoisovalerate + NH3 + NADH + H+ 1.4.1.1 alanine dehydrogenase
1.4.1.2 glutamate dehydrogenase
1.4.1.20 phenylalanine dehydrogenase
1.4.1.23 valine dehydrogenase (NAD+)
1.4.1.5 L-amino-acid dehydrogenase
1.4.1.8 valine dehydrogenase (NADP+)
1.4.1.9 leucine dehydrogenase







L-valine + 2-oxoglutarate <=> L-glutamate + 2-oxoisovalerate 2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.6 leucine transaminase
2.6.1.66 valine---pyruvate transaminase




2-oxoisovalerate + H+ <=> Isobutyraldehyde + CO2 2.2.1.6 acetolactate synthase
4.1.1.1 pyruvate decarboxylase
4.1.1.7 benzoylformate decarboxylase
4.1.1.72 branched-chain-2-oxoacid decarboxylase




2,3-dihydroxyisovalerate <=> 2-oxoisovalerate + H2O 4.2.1.9 dihydroxy-acid dehydratase

5,10-methylenetetrahydrofolate + 2-oxoisovalerate + H2O <=> ketopantoate + tetrahydrofolate 2.1.2.11 3-methyl-2-oxobutanoate hydroxymethyltransferase

(R)-2,3-dihydroxy-3-methylbutanoate <=> 2-oxoisovalerate + H2O 4.2.1.9 dihydroxy-acid dehydratase

2-oxoisovalerate + NADH <=> 2-Hydroxyisovalerate + NAD+ 1.1.1.27 L-lactate dehydrogenase
1.1.1.272 D-2-hydroxyacid dehydrogenase (NADP+)
1.1.1.28 D-lactate dehydrogenase
1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.345 D-2-hydroxyacid dehydrogenase (NAD+)
1.1.1.37 malate dehydrogenase






L-valine + H2O + O2 <=> 2-oxoisovalerate + NH3 + H2O2 1.4.3.2 L-amino-acid oxidase

D-valine + H2O + O2 <=> 2-oxoisovalerate + NH3 + H2O2 1.4.3.19 glycine oxidase
1.4.3.3 D-amino-acid oxidase


L-valine + 4-methylsulfanyl-2-oxobutanoate <=> 2-oxoisovalerate + L-methionine 2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.88 methionine transaminase



L-leucine + 2-oxoisovalerate <=> 4-methyl-2-oxopentanoate + L-valine 2.6.1.42 branched-chain-amino-acid transaminase

2-oxoisovalerate + Enzyme_N6-(lipoyl)lysine <=> [dihydrolipoyllysine-residue_(2-methylpropanoyl)transferase]_S-(2-methylpropanoyl)dihydrolipoyllysine + CO2 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)

2-oxoisovalerate + thiamine_diphosphate <=> 2-Methyl-1-hydroxypropyl-ThPP + CO2 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)

2-oxoisovalerate + [apo_BCAA_dehydrogenase_E2_protein]_N6-lipoyl-L-lysine + H+ <=> [apo_BCAA_dehydrogenase_E2_protein]_N6-S-[2-methylpropanoyl]dihydrolipoyl-L-lysine + CO2 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)

2-oxoisovalerate <=> 2-Oxopentanoate not assigned

5,10-methylenetetrahydromethanopterin + 2-oxoisovalerate + H2O <=> ketopantoate + 5,6,7,8-tetrahydromethanopterin 2.1.2.11 3-methyl-2-oxobutanoate hydroxymethyltransferase

DL-valine + H2O + O2 <=> 2-oxoisovalerate + NH3 + H2O2 1.4.3.2 L-amino-acid oxidase

D-valine + H2O + 2,6-dichlorophenolindophenol <=> 2-oxoisovalerate + NH3 + reduced_2,6-dichlorophenolindophenol 1.4.99.6 D-arginine dehydrogenase

D-valine + oxidized_acceptor + H2O <=> 2-oxoisovalerate + NH3 + reduced_acceptor 1.4.5.1 D-amino acid dehydrogenase (quinone)

2-oxoisovalerate + CoA + Oxidized_benzyl_viologen <=> isobutyryl-CoA + CO2 + reduced_benzyl_viologen 1.2.7.7 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)

D-valine + H2O + O2 <=> 2-oxoisovalerate + H2O2 1.4.3.19 glycine oxidase

2-Hydroxyisovalerate + O2 <=> 2-oxoisovalerate + H2O2 1.1.3.15 (S)-2-hydroxy-acid oxidase

L-tryptophan + 2-oxoisovalerate <=> 3-Indole-2-oxopropanoate + L-valine 2.6.1.28 tryptophan---phenylpyruvate transaminase
2.6.1.99 L-tryptophan---pyruvate aminotransferase


L-valine + 2-oxoisovalerate <=> 2-oxoisovalerate + L-leucine 2.6.1.42 branched-chain-amino-acid transaminase

L-valine + 2-oxoisovalerate <=> 2-oxoisovalerate + L-valine 2.6.1.42 branched-chain-amino-acid transaminase

2-Hydroxyisovalerate + 2,6-dichlorophenolindophenol <=> 2-oxoisovalerate + reduced_2,6-dichlorophenolindophenol 1.1.3.15 (S)-2-hydroxy-acid oxidase

2-oxoisovalerate + butyryl-CoA + H2O <=> 3-ethyl-2-hydroxy-2-isopropylsuccinic_acid + CoA 2.3.3.13 2-isopropylmalate synthase

L-isoleucine + 2-oxoisovalerate <=> 4-methyl-2-oxopentanoate + L-valine 2.6.1.42 branched-chain-amino-acid transaminase

2-oxoisovalerate + methylglyoxal <=> (S)-3-hydroxy-5-methylhexane-2,4-dione + CO2 2.2.1.5 2-hydroxy-3-oxoadipate synthase

D-alanine + 2-oxoisovalerate <=> pyruvate + D-valine 2.6.1.21 D-amino-acid transaminase

L-histidine + 2-oxoisovalerate <=> 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-valine 2.6.1.38 histidine transaminase

2-oxoisovalerate + propionyl-CoA + H2O <=> 2-hydroxy-2-isopropyl-3-methylsuccinic_acid + CoA 2.3.3.13 2-isopropylmalate synthase

D-valine + 2-oxoglutarate <=> 2-oxoisovalerate + D-glutamate 2.6.1.21 D-amino-acid transaminase

2-oxoisovalerate + H2O + methyl_viologen <=> isobutyryl-CoA + reduced_methyl_viologen + H+ 1.2.7.8 indolepyruvate ferredoxin oxidoreductase

L-kynurenine + 2-oxoisovalerate <=> Kynurenic_acid + DL-valine + H2O 2.6.1.7 kynurenine---oxoglutarate transaminase

L-leucine + H2O + NAD+ <=> 2-oxoisovalerate + NH3 + NADH + H+ 1.4.1.2 glutamate dehydrogenase

2-oxoisovalerate + NADH <=> Isovalerate + NAD+ 1.1.1.110 aromatic 2-oxoacid reductase

2-oxoisovalerate + acyl-CoA + NAD+ <=> Isobutyrate + CO2 + CoA + NADH + H+ 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)

beta-Alanine + 2-oxoisovalerate <=> malonate_semialdehyde + L-valine 2.6.1.18 beta-alanine---pyruvate transaminase

D-valine + H2O + methylene_blue <=> 2-oxoisovalerate + NH3 + reduced_methylene_blue 1.4.99.6 D-arginine dehydrogenase

L-leucine + 2-oxoisovalerate <=> 4-methyl-2-oxopentanoate + DL-valine 2.6.1.42 branched-chain-amino-acid transaminase

2-oxoisovalerate + NADPH + NH3 <=> L-leucine + NADP+ + H2O 1.4.1.2 glutamate dehydrogenase

2-oxoisovalerate + NH3 + NADPH + H+ <=> D-valine + H2O + NADP+ 1.4.99.6 D-arginine dehydrogenase

2-oxoisovalerate + NADPH <=> Isovalerate + NADP+ 1.1.1.110 aromatic 2-oxoacid reductase

2-oxoisovalerate + NADPH <=> 2-hydroxyvalerate + NADP+ 1.1.1.169 2-dehydropantoate 2-reductase

L-2-aminobutanoate + 2-oxoisovalerate <=> 2-oxobutyrate + L-valine 2.6.1.42 branched-chain-amino-acid transaminase

L-allo-isoleucine + 2-oxoisovalerate <=> 3-methyl-2-oxopentanoate + L-valine 2.6.1.42 branched-chain-amino-acid transaminase

L-valine + 2-oxobutyrate <=> 2-oxoisovalerate + 2-aminobutanoate 2.6.1.42 branched-chain-amino-acid transaminase

L-valine + 2-oxooctanoate <=> 2-oxoisovalerate + 2-aminooctanoate 2.6.1.42 branched-chain-amino-acid transaminase

2-oxoisovalerate + pentanoyl-CoA + H2O <=> 2-hydroxy-2-isopropyl-3-propylsuccinic_acid + CoA 2.3.3.13 2-isopropylmalate synthase

2-oxoisovalerate + [dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]-lipoyllysine <=> [dihydrolipoyllysine-residue_(2-methylpropanoyl)transferase]_S-(2-methylpropanoyl)dihydrolipoyllysine + CO2 + 2 H+ 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)

2-oxoisovalerate + [dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]-lipoyllysine <=> [dihydrolipoyllysine-residue_(2-methylpropanoyl)transferase]_S-butanoyl-dihydrolipoyllysine + CO2 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)

L-valine + 2-Oxohexanoate <=> 2-oxoisovalerate + 2-aminohexanoate 2.6.1.42 branched-chain-amino-acid transaminase

2-oxoisovalerate + glyoxylic_acid_ethyl_ester <=> (S)-ethyl_2-hydroxy-4-methyl-3-oxopentanoic_acid + CO2 2.2.1.5 2-hydroxy-3-oxoadipate synthase

2-oxoisovalerate + oxidized_2,6-dichlorophenolindophenol <=> Isobutyraldehyde + CO2 + reduced_2,6-dichlorophenolindophenol 1.2.4.1 pyruvate dehydrogenase (acetyl-transferring)

2-oxoisovalerate <=> Butyraldehyde + CO2 4.1.1.72 branched-chain-2-oxoacid decarboxylase

2-oxoisovalerate + malonyl-CoA + H2O <=> 2-hydroxy-3-metylbutane-11,2-tricarboxyl_acid + CoA 2.3.3.13 2-isopropylmalate synthase

2-Hydroxyisovalerate + acceptor <=> 2-oxoisovalerate + reduced_acceptor 1.1.99.31 (S)-mandelate dehydrogenase

D-valine + oxidized_2,6-dichlorophenolindophenol + H2O <=> 2-oxoisovalerate + NH3 + reduced_2,6-dichlorophenolindophenol 1.4.5.1 D-amino acid dehydrogenase (quinone)
1.4.99.6 D-arginine dehydrogenase
1.5.99.13 D-proline dehydrogenase



D-valine + 2-oxoadipate <=> 2-oxoisovalerate + 2-Aminoadipate 2.6.1.74 cephalosporin-C transaminase

L-valine + oxaloacetate <=> 2-oxoisovalerate + L-aspartate 2.6.1.42 branched-chain-amino-acid transaminase

2-oxoisovalerate + L-aspartate <=> L-norvaline + oxaloacetate 2.6.1.70 aspartate---phenylpyruvate transaminase

L-valine + glyoxylate <=> 2-oxoisovalerate + glycine 2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.44 alanine---glyoxylate transaminase
2.6.1.60 aromatic-amino-acid---glyoxylate transaminase



2-oxoisovalerate + glyoxylate <=> (S)-2-hydroxy-4-methyl-3-oxopentanoic_acid + CO2 2.2.1.5 2-hydroxy-3-oxoadipate synthase

L-glutamine + 2-oxoisovalerate <=> 2-Oxoglutaramate + L-valine 2.6.1.64 glutamine---phenylpyruvate transaminase

L-phenylalanine + 2-oxoisovalerate <=> phenylpyruvate + L-valine 2.6.1.28 tryptophan---phenylpyruvate transaminase

phenylpyruvate + DL-valine <=> L-phenylalanine + 2-oxoisovalerate 2.6.1.28 tryptophan---phenylpyruvate transaminase

2-oxoisovalerate + L-phenylalanine <=> L-norvaline + phenylpyruvate 2.6.1.70 aspartate---phenylpyruvate transaminase

2-oxoisovalerate + Lipoamide <=> CO2 + S-2-methylpropanoyldihydrolipoamide 1.2.4.4 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)

2-oxoisovalerate + NADPH + H+ <=> 2-Hydroxyisovalerate + NADP+ 1.1.1.169 2-dehydropantoate 2-reductase

(S)-2-Hydroxyisovalerate + O2 <=> 2-oxoisovalerate + H2O2 1.1.3.15 (S)-2-hydroxy-acid oxidase

2-oxoisovalerate + H+ + NADPH <=> 2-Hydroxyisovalerate + NADP+ not assigned