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polyamine pathway

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
S-adenosylmethioninamine + N4-aminopropylspermidine <=> S-methyl-5''-thioadenosine + N4-bis(aminopropyl)spermidine + H+ 2.5.1.128 N4-bis(aminopropyl)spermidine synthase

S-adenosylmethioninamine + spermidine <=> S-methyl-5''-thioadenosine + N4-aminopropylspermidine + H+ 2.5.1.128 N4-bis(aminopropyl)spermidine synthase

S-adenosylmethioninamine + norspermine <=> S-methyl-5''-thioadenosine + caldopentamine + H+ 2.5.1.126 norspermine synthase
2.5.1.127 caldopentamine synthase


S-adenosylmethioninamine + norspermidine <=> S-methyl-5''-thioadenosine + norspermine + H+ 2.5.1.104 N1-aminopropylagmatine synthase
2.5.1.126 norspermine synthase
2.5.1.127 caldopentamine synthase



N1-aminopropylagmatine + H2O <=> spermidine + Urea 3.5.3.24 N1-aminopropylagmatine ureohydrolase

agmatine + S-adenosylmethioninamine <=> N1-aminopropylagmatine + S-methyl-5''-thioadenosine + H+ 2.5.1.104 N1-aminopropylagmatine synthase

carboxyspermidine + H2O + NADP+ <=> L-aspartate_4-semialdehyde + putrescine + NADPH + H+ 1.4.1.B4
1.5.1.43 carboxynorspermidine synthase


carboxyspermidine + H+ <=> spermidine + CO2 4.1.1
4.1.1.96 carboxynorspermidine decarboxylase


H+ + carboxynorspermidine <=> norspermidine + CO2 4.1.1.96 carboxynorspermidine decarboxylase

carboxynorspermidine + NADP+ + H2O <=> L-aspartate_4-semialdehyde + 1,3-diaminopropane + NADPH + H+ 1.4.1.B4
1.5.1.43 carboxynorspermidine synthase


gamma-glutamyl-gamma-aminobutyraldehyde + NADP+ + H2O <=> 4-(glutamylamino)_butanoate + NADPH + H+ 1.2.1.99 4-(gamma-glutamylamino)butanal dehydrogenase

4-(glutamylamino)_butanoate + H2O <=> L-glutamate + 4-aminobutanoate 3.5.1.94 gamma-glutamyl-gamma-aminobutyrate hydrolase

H+ + L-2,4-diaminobutanoate <=> 1,3-diaminopropane + CO2 4.1.1.17 ornithine decarboxylase
4.1.1.18 lysine decarboxylase
4.1.1.86 diaminobutyrate decarboxylase



putrescine + L-glutamate + ATP <=> H+ + gamma-L-glutamylputrescine + ADP + phosphate 6.3.1.11 glutamate---putrescine ligase

putrescine + S-adenosylmethioninamine <=> H+ + spermidine + S-methyl-5''-thioadenosine 2.5.1.104 N1-aminopropylagmatine synthase
2.5.1.16 spermidine synthase
2.5.1.23 sym-norspermidine synthase



1,3-diaminopropane + S-adenosylmethioninamine <=> norspermidine + H+ + S-methyl-5''-thioadenosine 2.5.1.104 N1-aminopropylagmatine synthase
2.5.1.126 norspermine synthase
2.5.1.127 caldopentamine synthase
2.5.1.23 sym-norspermidine synthase




spermidine + S-adenosylmethioninamine <=> H+ + spermine + S-methyl-5''-thioadenosine 2.5.1.104 N1-aminopropylagmatine synthase
2.5.1.16 spermidine synthase
2.5.1.22 spermine synthase
2.5.1.23 sym-norspermidine synthase
2.5.1.79 thermospermine synthase





S-adenosyl-L-methionine + H+ <=> CO2 + S-adenosylmethioninamine 4.1.1.19 arginine decarboxylase
4.1.1.50 adenosylmethionine decarboxylase


H+ + L-arginine <=> CO2 + agmatine 4.1.1.19 arginine decarboxylase

H+ + L-ornithine <=> CO2 + putrescine 4.1.1.17 ornithine decarboxylase
4.1.1.18 lysine decarboxylase
4.1.1.19 arginine decarboxylase
4.1.1.86 diaminobutyrate decarboxylase
4.1.1.B12





H2O + agmatine <=> Urea + putrescine 3.5.3.1 arginase
3.5.3.11 agmatinase


H2O + agmatine <=> NH3 + N-Carbamoylputrescine 3.5.3.12 agmatine deiminase

H+ + N-Carbamoylputrescine + H2O <=> putrescine + CO2 + NH3 3.5.1.53 N-carbamoylputrescine amidase

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