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formaldehyde assimilation I (serine pathway)

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
D-glycerate + NADP+ <=> Hydroxypyruvate + NADPH + H+ 1.1.1
1.1.1.215 gluconate 2-dehydrogenase
1.1.1.27 L-lactate dehydrogenase
1.1.1.60 2-hydroxy-3-oxopropionate reductase
1.1.1.79 glyoxylate reductase (NADP+)
1.1.1.81 hydroxypyruvate reductase
1.1.1.86 ketol-acid reductoisomerase (NADP+)
1.1.1.92 oxaloglycolate reductase (decarboxylating)








formaldehyde + tetrahydrofolate <=> 5,10-methylenetetrahydrofolate + H2O 2.1.2.11 3-methyl-2-oxobutanoate hydroxymethyltransferase

L-serine + tetrahydrofolate <=> glycine + 5,10-methylenetetrahydrofolate + H2O 2.1.2.1 glycine hydroxymethyltransferase

(3S)-3-carboxy-3-hydroxypropanoyl-CoA <=> glyoxylate + acetyl-CoA 4.1.3.24 malyl-CoA lyase

(S)-malate + NAD+ <=> oxaloacetate + NADH + H+ 1.1.1.27 L-lactate dehydrogenase
1.1.1.28 D-lactate dehydrogenase
1.1.1.299 malate dehydrogenase [NAD(P)+]
1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.37 malate dehydrogenase
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating)
1.1.1.81 hydroxypyruvate reductase
1.1.1.82 malate dehydrogenase (NADP+)
1.1.1.85 3-isopropylmalate dehydrogenase
1.1.1.95 phosphoglycerate dehydrogenase
1.1.1.96 diiodophenylpyruvate reductase












glyoxylate + L-serine <=> Hydroxypyruvate + glycine 2.6.1.15 glutamine---pyruvate transaminase
2.6.1.35 glycine---oxaloacetate transaminase
2.6.1.4 glycine transaminase
2.6.1.44 alanine---glyoxylate transaminase
2.6.1.45 serine---glyoxylate transaminase
2.6.1.51 serine---pyruvate transaminase
2.6.1.60 aromatic-amino-acid---glyoxylate transaminase







acetyl-CoA + oxidized_electron_transfer_flavoprotein + NADPH + CO2 + H+ <=> H+ + glyoxylate + propionyl-CoA + CoA + reduced_flavodoxin + NADP+ not assigned

2-phospho-D-glycerate <=> 3-phospho-D-glycerate 5.4.2.11 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)
5.4.2.12 phosphoglycerate mutase (2,3-diphosphoglycerate-independent)


D-glycerate + ATP <=> H+ + 2-phospho-D-glycerate + ADP 2.7.1.165 glycerate 2-kinase

glyoxylate + L-serine <=> Hydroxypyruvate + glycine 2.6.1.15 glutamine---pyruvate transaminase
2.6.1.35 glycine---oxaloacetate transaminase
2.6.1.4 glycine transaminase
2.6.1.44 alanine---glyoxylate transaminase
2.6.1.45 serine---glyoxylate transaminase
2.6.1.51 serine---pyruvate transaminase
2.6.1.60 aromatic-amino-acid---glyoxylate transaminase







(S)-malate + CoA + ATP <=> phosphate + (3S)-3-carboxy-3-hydroxypropanoyl-CoA + ADP 6.2.1.5 succinate---CoA ligase (ADP-forming)
6.2.1.9 malate---CoA ligase


phosphate + oxaloacetate <=> phosphoenolpyruvate + HCO3- 4.1.1.31 phosphoenolpyruvate carboxylase

2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O 4.2.1.11 phosphopyruvate hydratase

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