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daunorubicin biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
10-carboxy-3-deoxycarminomycin + H+ <=> 13-deoxycarminomycin + CO2 4.1.1

13-dihydrodaunorubicin + NADPH + H+ + O2 <=> daunorubicin + NADP+ + H2O 1.14.13.181 13-deoxydaunorubicin hydroxylase

9-hydroxy-3,5,7,11,13,15,17,19-octaoxohenicosanoyl-[acp] + NADP+ <=> 3,5,7,9,11,13,15,17,19-nonaoxohenicosanoyl-[acp] + NADPH + H+ 1.1.1

S-adenosyl-L-methionine + 13-dihydrocarminomycin <=> 13-dihydrodaunorubicin + S-adenosyl-L-homocysteine + H+ 2.1.1.292 carminomycin 4-O-methyltransferase

S-adenosyl-L-methionine + aklanonate <=> S-adenosyl-L-homocysteine + methyl_aklanonate 2.1.1.288 aklanonic acid methyltransferase

aklavinone + NADP+ <=> aklaviketone + NADPH + H+ 1.1.1.362 aklaviketone reductase

rhodomycin_D + H2O <=> 10-carboxy-3-deoxycarminomycin + methanol + H+ 3.1.1

aklaviketone <=> methyl_aklanonate 5.5.1.23 aklanonic acid methyl ester cyclase

propionyl-CoA + malonyl-CoA + polyketide-[acp] + H+ <=> 3,5,7,9,11,13,15,17,19-nonaoxohenicosanoyl-[acp] + CO2 + CoA 2.3.1

12-deoxyaklanoate + O2 <=> aklanonate + H2O 1.13.12

S-adenosyl-L-methionine + carminomycin <=> daunorubicin + S-adenosyl-L-homocysteine + H+ 2.1.1.292 carminomycin 4-O-methyltransferase

epsilon-rhodomycinone + dTDP-L-daunosamine <=> rhodomycin_D + dTDP + H+ 2.4.1

13-deoxydaunorubicin + NADPH + H+ + O2 <=> 13-dihydrodaunorubicin + NADP+ + H2O 1.14.13.181 13-deoxydaunorubicin hydroxylase

13-deoxycarminomycin + NADPH + H+ + O2 <=> 13-dihydrocarminomycin + NADP+ + H2O 1.14.13.181 13-deoxydaunorubicin hydroxylase

S-adenosyl-L-methionine + 13-deoxycarminomycin <=> 13-deoxydaunorubicin + S-adenosyl-L-homocysteine + H+ 2.1.1.292 carminomycin 4-O-methyltransferase

6-[3-hydroxy-2-(3,5,7-trioxononanoyl)phenyl]-3,5-dioxohexanoate <=> 12-deoxyaklanoate + H2O 4.2.1

13-dihydrocarminomycin + NADPH + H+ + O2 <=> carminomycin + NADP+ + H2O 1.14.13.181 13-deoxydaunorubicin hydroxylase

aklavinone + NADPH + H+ + O2 <=> epsilon-rhodomycinone + NADP+ + H2O 1.14.13.180 aklavinone 12-hydroxylase

9-hydroxy-3,5,7,11,13,15,17,19-octaoxohenicosanoyl-[acp] <=> 6-[3-hydroxy-2-(3,5,7-trioxononanoyl)phenyl]-3,5-dioxohexanoate + polyketide-[acp] + H2O + H+ 4.2.1

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