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cholesterol degradation to androstenedione II (cholesterol dehydrogenase)

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
(25S)-26-hydroxycholest-4-en-3-one + reduced_ferredoxin_[iron-sulfur]_cluster + H+ + O2 <=> (25S)-26-oxocholest-4-en-3-one + oxidized_ferredoxin + H2O 1.14.15.29 cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]

22-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD+ <=> 3,22-dioxochol-4-en-24-oyl-CoA + NADH + H+ 1.1.1

17-hydroxy-3-oxo-4-pregnane-20-carboxyl-CoA <=> 4-androstene-3,17-dione + propionyl-CoA 2.3.1

3-oxo-23,24-bisnorchol-4-en-22-oic_acid-CoA + acetyl-CoA <=> 3,22-dioxochol-4-en-24-oyl-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase

24-hydroxy-3-oxocholest-4-en-26-oyl-CoA <=> 3-oxocholest-4,24-dien-26-oyl-CoA + H2O 4.2.1

(25R)-26-hydroxycholest-4-en-3-one + reduced_ferredoxin_[iron-sulfur]_cluster + H+ + O2 <=> (25R)-26-oxocholest-4-en-3-one + oxidized_ferredoxin + H2O 1.14.15.28 cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]

22-hydroxy-3-oxochol-4-en-24-oyl-CoA <=> 3-oxochol-4,22-dien-24-oyl-CoA + H2O 4.2.1

(25R)-26-oxocholest-4-en-3-one + reduced_ferredoxin_[iron-sulfur]_cluster + O2 + H+ <=> (25R)-3-oxocholest-4-en-26-oate + oxidized_ferredoxin + H2O 1.14.15.28 cholest-4-en-3-one 26-monooxygenase [(25R)-3-oxocholest-4-en-26-oate forming]

(25S)-3-oxocholest-4-en-26-oyl-CoA <=> (25R)-3-oxocholest-4-en-26-oyl-CoA 5.1.99.4 alpha-methylacyl-CoA racemase

5-Cholesten-3-one <=> cholest-4-en-3-one 5.3.3.1 steroid Delta-isomerase

(25S)-3-oxocholest-4-en-26-oate + ATP + CoA <=> (25S)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate 6.2.1.42 3-oxocholest-4-en-26-oate---CoA ligase

cholesterol + NAD+ <=> 5-Cholesten-3-one + NADH + H+ 1.1.1.145 3beta-hydroxy-Delta5-steroid dehydrogenase

3-oxochol-4-en-24-oyl-CoA + propionyl-CoA <=> 3,24-dioxocholest-4-en-26-oyl-CoA + CoA 2.3.1.176 propanoyl-CoA C-acyltransferase

24-hydroxy-3-oxocholest-4-en-26-oyl-CoA + NAD+ <=> 3,24-dioxocholest-4-en-26-oyl-CoA + NADH + H+ 1.1.1.35 3-hydroxyacyl-CoA dehydrogenase

(25S)-26-oxocholest-4-en-3-one + reduced_ferredoxin_[iron-sulfur]_cluster + O2 + H+ <=> (25S)-3-oxocholest-4-en-26-oate + oxidized_ferredoxin + H2O 1.14.15.29 cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]

cholest-4-en-3-one + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> (25R)-26-hydroxycholest-4-en-3-one + H2O + oxidized_ferredoxin not assigned

3-oxochol-4-en-24-oyl-CoA + acceptor <=> 3-oxochol-4,22-dien-24-oyl-CoA + reduced_acceptor 1.3.99

(25R)-3-oxocholest-4-en-26-oate + ATP + CoA <=> (25R)-3-oxocholest-4-en-26-oyl-CoA + AMP + diphosphate 6.2.1.42 3-oxocholest-4-en-26-oate---CoA ligase

17-hydroxy-3-oxo-4-pregnane-20-carboxyl-CoA <=> 3-oxo-4,17-pregnadiene-20-carboxyl-CoA + H2O 4.2.1

3-oxo-23,24-bisnorchol-4-en-22-oic_acid-CoA + acceptor <=> 3-oxo-4,17-pregnadiene-20-carboxyl-CoA + reduced_acceptor 1.3.99

cholest-4-en-3-one + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> (25S)-26-hydroxycholest-4-en-3-one + H2O + oxidized_ferredoxin 1.14.15.29 cholest-4-en-3-one 26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming]

(25S)-3-oxocholest-4-en-26-oyl-CoA + acceptor <=> 3-oxocholest-4,24-dien-26-oyl-CoA + reduced_acceptor 1.3.99

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