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androstenedione degradation

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
7-carboxy-4-methyl-5-oxoheptanoyl-CoA + oxidized_electron_transfer_flavoprotein + H+ <=> (2E)-7-carboxy-4-methyl-5-oxohept-2-enoyl-CoA + reduced_flavodoxin 1.3.8

propionaldehyde + CoA + NAD+ <=> propionyl-CoA + NADH + H+ 1.2.1.10 acetaldehyde dehydrogenase (acetylating)
1.2.1.27 methylmalonate-semialdehyde dehydrogenase (CoA-acylating)
1.2.1.57 butanal dehydrogenase
1.2.1.87 propanal dehydrogenase (CoA-propanoylating)




3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione + O2 + FMNH2 <=> H+ + 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + H2O + FMN 1.14.14.12 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase

3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 <=> H+ + 4,5-9,10-diseco-3-hydroxy-5,9,17-tri-oxoandrosta-1(10),2-diene-4-oic_acid 1.13.11.25 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase

(3R)-2-(2-carboxyethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H2O <=> 9-carboxy-6-methyl-3,7-dioxononanoyl-CoA 4.1.99

(3R)-7-carboxy-3-hydroxy-4-methyl-5-oxoheptanoyl-CoA + NAD+ <=> 7-carboxy-4-methyl-3,5-dioxoheptanoyl-CoA + NADH + H+ 1.1.1.35 3-hydroxyacyl-CoA dehydrogenase

3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate 6.2.1.41 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate---CoA ligase

9alpha-hydroxy-1,4-androstadiene_3,17-dione <=> 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 0.0.0.0

4,5-9,10-diseco-3-hydroxy-5,9,17-tri-oxoandrosta-1(10),2-diene-4-oic_acid + H2O <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H+ 3.7.1.17 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase

3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + acetyl-CoA <=> 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]-3-oxopropanoyl-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase

5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + acceptor <=> (2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + reduced_acceptor 1.3.99

3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]-3-hydroxypropanoyl-CoA <=> (2E)-3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]prop-2-enoyl-CoA + H2O 4.2.1

(5R,7aS)-7a-methyl-1,5-dioxo-3,5,6,7-tetrahydro-2H-indene-4-carboxyl-CoA + H2O <=> (3R)-2-(2-carboxyethyl)-3-methyl-6-oxocyclohex-1-ene-1-carboxyl-CoA + H+ 4.1.99

3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-indene-4-carboxyl-CoA + NAD+ <=> (5R,7aS)-5-hydroxy-7a-methyl-1-oxo-3,5,6,7-tetrahydro-2H-indene-4-carboxyl-CoA + NADH + H+ 1.3.1

(S)-4-hydroxy-2-oxohexanoate <=> pyruvate + propionaldehyde 4.1.3.43 4-hydroxy-2-oxohexanoate aldolase

3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]-3-hydroxypropanoyl-CoA + NAD+ <=> 3-[(3aS,4S,5R,7aS)-5-hydroxy-7a-methyl-1-oxo-octahydro-1H-inden-4-yl]-3-oxopropanoyl-CoA + NADH + H+ 1.1.1.35 3-hydroxyacyl-CoA dehydrogenase

(3R)-7-carboxy-3-hydroxy-4-methyl-5-oxoheptanoyl-CoA <=> (2E)-7-carboxy-4-methyl-5-oxohept-2-enoyl-CoA + H2O 4.2.1.119 enoyl-CoA hydratase 2

(5R,7aS)-5-hydroxy-7a-methyl-1-oxo-3,5,6,7-tetrahydro-2H-indene-4-carboxyl-CoA + NAD+ <=> (5R,7aS)-7a-methyl-1,5-dioxo-3,5,6,7-tetrahydro-2H-indene-4-carboxyl-CoA + NADH + H+ 1.1.1

1,4-androstadiene-3,17-dione + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> 9alpha-hydroxy-1,4-androstadiene_3,17-dione + oxidized_ferredoxin + H2O 1.14.15.30 3-ketosteroid 9alpha-monooxygenase

succinyl-CoA + propionyl-CoA <=> 5-carboxy-2-methyl-3-oxopentanoyl-CoA + CoA 2.3.1

5-hydroxy-3-[(3aS,4S,5R,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + NADP+ <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + NADPH + H+ 1.1.1.145 3beta-hydroxy-Delta5-steroid dehydrogenase

(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O <=> (S)-4-hydroxy-2-oxohexanoate 4.2.1.132 2-hydroxyhexa-2,4-dienoate hydratase

5-carboxy-2-methyl-3-oxopentanoyl-CoA + acetyl-CoA <=> 7-carboxy-4-methyl-3,5-dioxoheptanoyl-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase

7-carboxy-4-methyl-5-oxoheptanoyl-CoA + acetyl-CoA <=> 9-carboxy-6-methyl-3,7-dioxononanoyl-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase

4-androstene-3,17-dione + acceptor <=> 1,4-androstadiene-3,17-dione + reduced_acceptor 1.3.99.4 3-oxosteroid 1-dehydrogenase

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