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androgen and estrogen metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
pregnenolone + NADH + H+ <=> progesterone + NAD+ 1.1.1.270 3beta-hydroxysteroid 3-dehydrogenase

testosterone + NADPH + H+ <=> 4-androstene-3,17-dione + NADP+ 1.1.1.357 3alpha-hydroxysteroid 3-dehydrogenase

cholesterol + O2 + reduced_adrenodoxin + H+ <=> pregnenolone + 4-Methylpentanal + H2O + oxidized_ferredoxin 1.14.15.6 cholesterol monooxygenase (side-chain-cleaving)

pregnenolone + NAD+ <=> progesterone + NADH + H+ 1.1.1.145 3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase
5.3.3.1 steroid Delta-isomerase



3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + ATP + CoA <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA + AMP + diphosphate 6.2.1.41 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate---CoA ligase

(S)-4-hydroxy-2-oxohexanoate <=> pyruvate + propionaldehyde 4.1.3.43 4-hydroxy-2-oxohexanoate aldolase

propionaldehyde + CoA + NAD+ <=> propionyl-CoA + NADH + H+ 1.2.1.10 acetaldehyde dehydrogenase (acetylating)
1.2.1.27 methylmalonate-semialdehyde dehydrogenase (CoA-acylating)
1.2.1.57 butanal dehydrogenase
1.2.1.87 propanal dehydrogenase (CoA-propanoylating)




4,5-9,10-diseco-3-hydroxy-5,9,17-tri-oxoandrosta-1(10),2-diene-4-oic_acid + H2O <=> 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H+ 3.7.1.17 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase

1,4-androstadiene-3,17-dione + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> 9alpha-hydroxy-1,4-androstadiene_3,17-dione + oxidized_ferredoxin + H2O 1.14.15.30 3-ketosteroid 9alpha-monooxygenase

3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione + O2 + FMNH2 <=> H+ + 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + H2O + FMN 1.14.14.12 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase

3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 <=> H+ + 4,5-9,10-diseco-3-hydroxy-5,9,17-tri-oxoandrosta-1(10),2-diene-4-oic_acid 1.13.11.25 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase

17alpha-hydroxyprogesterone + flavin_hydroquinone + O2 <=> 4-androstene-3,17-dione + acetate + [oxidized_NADPH-hemoprotein_reductase] + H2O 1.14.14.32 17alpha-hydroxyprogesterone deacetylase

testosterone + NADP+ <=> 4-androstene-3,17-dione + NADPH + H+ 1.1.1.146 11beta-hydroxysteroid dehydrogenase
1.1.1.148 estradiol 17alpha-dehydrogenase
1.1.1.184 carbonyl reductase (NADPH)
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.209 3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.213 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.239 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.50 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62 17beta-estradiol 17-dehydrogenase
1.1.1.64 testosterone 17beta-dehydrogenase (NADP+)











testosterone + NAD+ <=> 4-androstene-3,17-dione + NADH + H+ 1.1.1.112 indanol dehydrogenase
1.1.1.210 3beta(or 20alpha)-hydroxysteroid dehydrogenase
1.1.1.239 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.357 3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62 17beta-estradiol 17-dehydrogenase
1.1.1.64 testosterone 17beta-dehydrogenase (NADP+)







cholesterol + O2 + reduced_adrenodoxin + H+ <=> pregnenolone + 4-Methylpentanal + H2O + oxidized_ferredoxin 1.14.15.6 cholesterol monooxygenase (side-chain-cleaving)

9alpha-hydroxy-1,4-androstadiene_3,17-dione <=> 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 0.0.0.0

17alpha-hydroxyprogesterone + reduced_[NADPH-hemoprotein_reductase] + O2 <=> 4-androstene-3,17-dione + acetate + oxidized_[NADPH-hemoprotein_reductase] + H2O + H+ 1.14.14.32 17alpha-hydroxyprogesterone deacetylase

(2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H2O <=> (S)-4-hydroxy-2-oxohexanoate 4.2.1.132 2-hydroxyhexa-2,4-dienoate hydratase

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