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Xylene degradation

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
4-Methylbenzoate + O2 + NADPH + H+ <=> cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NADP+ 1.14.12

2-hydroxy-2,4-pentadienoate + acetate <=> 2-hydroxy-6-oxohepta-2,4-dienoate + H2O 3.7.1.25 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase

2-Hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate <=> 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + CO2 4.1.1

2-Methylbenzaldehyde + NADP+ + H2O <=> 2-Methylbenzoate + NADPH + H+ 1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.7 benzaldehyde dehydrogenase (NADP+)


3-methylbenzoate + NADH + O2 + H+ <=> 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate + NAD+ 1.14.12

4-cymene + reduced_ferredoxin_[iron-sulfur]_cluster + O2 + H+ <=> 4-Isopropylbenzyl_alcohol + oxidized_ferredoxin + H2O 1.14.15.25 p-cymene methyl-monooxygenase

2-Oxo-5-methyl-cis-muconate <=> (2E,4Z)-2-hydroxyhexa-2,4-dienoate + CO2 4.1.1.77 2-oxo-3-hexenedioate decarboxylase

(2E,4Z)-2-hydroxy-5-methylhexa-2,4-diendioate <=> 2-Oxo-5-methyl-cis-muconate 5.3.2.6 2-hydroxymuconate tautomerase

4-methylcatechol + O2 <=> 2-Hydroxy-5-methyl-cis,cis-muconic_semialdehyde 1.13.11.2 catechol 2,3-dioxygenase

3-methylbenzaldehyde + NADP+ + H2O <=> 3-methylbenzoate + NADPH + H+ 1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.7 benzaldehyde dehydrogenase (NADP+)


2-Methylbenzyl_alcohol + NAD+ <=> 2-Methylbenzaldehyde + NADH 1.1.1.90 aryl-alcohol dehydrogenase

4-Methylbenzoate + O2 + NADH + H+ <=> cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NAD+ 1.14.12

NAD+ + 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate <=> CO2 + NADH + 3-methylcatechol 1.3.1.68 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase

2,3-Dihydroxy-p-cumate + O2 <=> 2-Hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate + H+ 1.13.11
1.13.11.M5


NAD+ + cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate <=> CO2 + NADH + 4-methylcatechol 1.3.1.67 cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase

1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate + NAD+ <=> 3-methylcatechol + CO2 + NADH + H+ 1.3.1

3-methylbenzyl_alcohol + NAD+ <=> H+ + 3-methylbenzaldehyde + NADH 1.1.1.21 aldehyde reductase
1.1.1.90 aryl-alcohol dehydrogenase


xylene + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> 3-methylbenzyl_alcohol + oxidized_ferredoxin + H2O 1.14.15.26 toluene methyl-monooxygenase

4-Isopropylbenzyl_alcohol + NAD+ <=> cuminaldehyde + NADH + H+ 1.1.1.90 aryl-alcohol dehydrogenase
1.1.1.M33


p-xylene + O2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ <=> 4-methylbenzyl_alcohol + oxidized_ferredoxin + H2O 1.14.15.26 toluene methyl-monooxygenase

NADP+ + cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate <=> CO2 + NADPH + 4-methylcatechol 1.3.1.67 cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase

4-methylbenzyl_alcohol + NAD+ <=> H+ + 4-methylbenzaldehyde + NADH 1.1.1.21 aldehyde reductase
1.1.1.90 aryl-alcohol dehydrogenase


propionaldehyde + pyruvate <=> 4-hydroxy-2-oxohexanoate 4.1.2.52 4-hydroxy-2-oxoheptanedioate aldolase
4.1.3.39 4-hydroxy-2-oxovalerate aldolase
4.1.3.43 4-hydroxy-2-oxohexanoate aldolase



4-hydroxy-2-oxopentanoate <=> pyruvate + acetaldehyde 4.1.2.52 4-hydroxy-2-oxoheptanedioate aldolase
4.1.3.17 4-hydroxy-4-methyl-2-oxoglutarate aldolase
4.1.3.39 4-hydroxy-2-oxovalerate aldolase
4.1.3.43 4-hydroxy-2-oxohexanoate aldolase




propionaldehyde + CoA + NAD+ <=> propionyl-CoA + NADH + H+ 1.2.1.10 acetaldehyde dehydrogenase (acetylating)
1.2.1.27 methylmalonate-semialdehyde dehydrogenase (CoA-acylating)
1.2.1.57 butanal dehydrogenase
1.2.1.87 propanal dehydrogenase (CoA-propanoylating)




4-hydroxy-2-oxopentanoate <=> 2-oxopent-4-enoate + H2O 4.2.1.80 2-oxopent-4-enoate hydratase

acetaldehyde + CoA + NAD+ <=> acetyl-CoA + NADH + H+ 1.2.1.10 acetaldehyde dehydrogenase (acetylating)
1.2.1.42 hexadecanal dehydrogenase (acylating)
1.2.1.57 butanal dehydrogenase
1.2.1.87 propanal dehydrogenase (CoA-propanoylating)




2-Hydroxy-5-methyl-cis,cis-muconic_semialdehyde + H2O <=> formate + (2E,4Z)-2-hydroxyhexa-2,4-dienoate 3.7.1.9 2-hydroxymuconate-6-semialdehyde hydrolase

2-Methylbenzoate + O2 + NADH + H+ <=> 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate + NAD+ 1.14.12

3-methylcatechol + O2 <=> 2-hydroxy-6-oxohepta-2,4-dienoate + H+ 1.13.11
1.13.11.16 3-carboxyethylcatechol 2,3-dioxygenase
1.13.11.2 catechol 2,3-dioxygenase
1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase
1.13.11.56 1,2-dihydroxynaphthalene dioxygenase





4-methylbenzaldehyde + NADP+ + H2O <=> 4-Methylbenzoate + NADPH + H+ 1.2.1.28 benzaldehyde dehydrogenase (NAD+)
1.2.1.7 benzaldehyde dehydrogenase (NADP+)


cis-5,6-dihydroxy-4-isopropylcyclohexa-1,3-dienecarboxylate + NAD+ <=> H+ + 2,3-Dihydroxy-p-cumate + NADH 1.3.1.58 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase

2-Hydroxy-5-methyl-cis,cis-muconic_semialdehyde + NAD+ + H2O <=> (2E,4Z)-2-hydroxy-5-methylhexa-2,4-diendioate + NADH + H+ 1.2.1.85 2-hydroxymuconate-6-semialdehyde dehydrogenase

2-xylene + O2 + 2 reduced_ferredoxin_[iron-sulfur]_cluster + 2 H+ <=> 2-Methylbenzyl_alcohol + 2 oxidized_ferredoxin + H2O 1.14.15.26 toluene methyl-monooxygenase

H+ + cumic_acid + NADH + O2 <=> cis-5,6-dihydroxy-4-isopropylcyclohexa-1,3-dienecarboxylate + NAD+ 1.14.12.25 p-cumate 2,3-dioxygenase

2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O <=> Isobutyrate + 2-hydroxy-2,4-pentadienoate 3.7.1

cuminaldehyde + NAD+ + H2O <=> H+ + cumic_acid + NADH 1.2.1.29 aryl-aldehyde dehydrogenase

(2E,4Z)-2-hydroxyhexa-2,4-dienoate + H2O <=> 4-hydroxy-2-oxohexanoate 4.2.1.132 2-hydroxyhexa-2,4-dienoate hydratase

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