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Microbial metabolism in diverse environments

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
Trichloroethylene + 2 H+ <=> trans-dichloroethylene + Hydrochloric_acid 1.21.99.5 tetrachloroethene reductive dehalogenase

Glutarate + 2-oxoglutarate + O2 <=> (S)-2-hydroxyglutarate + succinate + CO2 1.14.11.64 glutarate dioxygenase

4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate <=> 2-Pyrone-4,6-dicarboxylate + methanol not assigned

NH3 + NADP+ + H2O <=> nitrite + NADPH + H+ 1.7.1.4 nitrite reductase [NAD(P)H]
1.7.7.1 ferredoxin---nitrite reductase
1.8.1.2 assimilatory sulfite reductase (NADPH)



cis-1,2-dihydrobenzene-3-chloro-(R,R)-1,2-diol + NAD+ <=> 3-chlorocatechol + NADH + H+ 1.3.1.119 chlorobenzene dihydrodiol dehydrogenase
1.3.1.19 cis-1,2-dihydrobenzene-1,2-diol dehydrogenase


1-hydroxy-2-naphthaldehyde + pyruvate <=> (3E)-4-(1-hydroxynaphthalen-2-yl)-2-oxobut-3-enoate + H2O 4.1.2
4.1.2.45 trans-o-hydroxybenzylidenepyruvate hydratase-aldolase


1,2,3,4-tetrachlorobenzene + O2 + NADH + H+ <=> cis-Chlorobenzene_dihydrodiol + NAD+ 1.14.12

2-Chloroethanol + 2 ferricytochrome_c <=> Chloroacetaldehyde + 2 ferricytochrome_c + 2 H+ 1.1.2.8 alcohol dehydrogenase (cytochrome c)

catechol + O2 <=> H+ + cis,cis-muconate 1.13.11.1 catechol 1,2-dioxygenase
1.13.11.3 protocatechuate 3,4-dioxygenase
1.13.11.37 hydroxyquinol 1,2-dioxygenase



Dimethylamine + H2O + flavin <=> methylamine + formaldehyde + reduced_flavodoxin 1.5.8.1 dimethylamine dehydrogenase

Pyrene-4,5-oxide + H2O <=> trans-4,5-Dihydroxy-4,5-dihydropyrene 3.3.2

cis-1,2-Cyclohexanediol + NAD+ <=> 2-Hydroxycyclohexan-1-one + NADH 1.1.1.174 cyclohexane-1,2-diol dehydrogenase

2 Atrazine + O2 <=> 2 desethylatrazine + 2 acetaldehyde 1.14.15

5-methyltetrahydrosarcinapterin + coenzyme_M + 2 Sodium_cation(in) <=> tetrahydrosarcinapterin + methyl-CoM + 2 Sodium_cation(out) 2.1.1.86 tetrahydromethanopterin S-methyltransferase

Cyclohexane + NADH + H+ + O2 <=> Cyclohexanol + NAD+ + H2O 1.14.13
1.14.13.25 methane monooxygenase (soluble)
1.14.15.3 alkane 1-monooxygenase



formaldehyde + H2O <=> methanol + formate + H+ 1.2.98.1 formaldehyde dismutase

H+ + melamine + H2O <=> ammeline + NH3 3.5.4.45 melamine deaminase
3.8.1.8 atrazine chlorohydrolase


Monobromobisphenol_A <=> bisphenol_A + Hydrobromic_acid 1.97.1

4-nitrocatechol + O2 + 3 H+ <=> Hydroxyquinol + nitrite + H2O 1.14

(S)-malate + NADP+ <=> pyruvate + CO2 + NADPH 1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating)
1.1.1.39 malate dehydrogenase (decarboxylating)
1.1.1.40 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
1.1.1.85 3-isopropylmalate dehydrogenase




phenylacetaldehyde + NADP+ + H2O <=> phenylacetate + NADPH + H+ 1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.39 phenylacetaldehyde dehydrogenase
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.8 betaine-aldehyde dehydrogenase




2-hydroxy-6-oxoocta-2,4-dienoate + H2O <=> 2-hydroxy-2,4-pentadienoate + propionate 3.7.1

Toluene + O2 + NADH + H+ <=> (1S,2R)-3-Methylcyclohexa-3,5-diene-1,2-diol + NAD+ 1.14.12.11 toluene dioxygenase

dibenzo-p-dioxin + NADH + O2 <=> 2,2'',3-trihydroxybiphenyl_ether + NAD+ 1.14.12
1.14.12.18 biphenyl 2,3-dioxygenase
1.14.12.22 carbazole 1,9a-dioxygenase



4-hydroxyphenylacetate + O2 + NADPH + H+ <=> homogentisate + H2O + NADP+ 1.14.13.18 4-hydroxyphenylacetate 1-monooxygenase

D-glyceraldehyde_3-phosphate + NADP+ + H2O <=> H+ + 3-phospho-D-glycerate + NADPH 1.2.1.89 D-glyceraldehyde dehydrogenase (NADP+)
1.2.1.9 glyceraldehyde-3-phosphate dehydrogenase (NADP+)
1.2.1.90 glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]



4-hydroxybenzaldehyde + NADP+ + H2O <=> 4-hydroxybenzoate + NADPH + H+ 1.2.1.4 aldehyde dehydrogenase (NADP+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.67 vanillin dehydrogenase
1.2.1.7 benzaldehyde dehydrogenase (NADP+)
1.2.1.96 4-hydroxybenzaldehyde dehydrogenase (NADP+)





O2 + H2O + pyridoxal <=> H+ + H2O2 + 4-pyridoxate 1.2.3.1 aldehyde oxidase
1.2.3.8 pyridoxal oxidase


(RS)-nicotine + O2 <=> N-methylmyosmine + H2O2 1.5.3

4-hydroxy-4-methyl-2-oxoglutarate <=> pyruvate 4.1.3.17 4-hydroxy-4-methyl-2-oxoglutarate aldolase

Dibromobisphenol_A <=> Monobromobisphenol_A + Hydrobromic_acid 1.97.1

Trichloroethylene + O2 + 2 H2O + NADH + H+ <=> 2 formate + 3 Hydrochloric_acid + NAD+ 1.14.12.11 toluene dioxygenase

fluorene + O2 + NADH + H+ <=> (3S,4R)-cis-3,4dihydroxy-3,4-dihydrofluorene + NAD+ 1.14.12
1.14.12.12 naphthalene 1,2-dioxygenase


3-hydroxycinnamic_acid + O2 + NADH + H+ <=> (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD+ 1.14.13.127 3-(3-hydroxyphenyl)propanoate hydroxylase

4''-chloro-2,3-dihydroxybiphenyl + O2 <=> 2-hydroxy-6-oxo-6-(4''-chlorophenyl)-hexa-2,4-dienoate + H2O 1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase

2-Hydroxyisophthalic_acid <=> salicylate + CO2 4.1.1

6-hydroxycyclohex-1-ene-1-carbonyl-CoA <=> cyclohexa-1,5-diene-1-carbonyl-CoA + H2O 4.2.1.100 cyclohexa-1,5-dienecarbonyl-CoA hydratase

2-methylnaphthalene + O2 + NADH + H+ <=> cis-1,2-Dihydroxy-1,2-dihydro-7-methylnaphthalene + NAD+ 1.14.12.12 naphthalene 1,2-dioxygenase

1,3-dicarboxyurea + H+ <=> allophanate + CO2 not assigned

phosphoenolpyruvate + CO2 <=> phosphate + oxaloacetate 4.1.1.31 phosphoenolpyruvate carboxylase

hydroquinone + O2 <=> 4-hydroxymuconic_acid_semialdehyde + H+ 1.13.11.66 hydroquinone 1,2-dioxygenase

trans-3-chloroacrylate <=> malonate_semialdehyde + Cl- 3.8.1
5.3.2.1 phenylpyruvate tautomerase


2-sulfoacetaldehyde <=> coenzyme_M not assigned

trimethylamine + 2 ferricytochrome_c + H2O <=> Trimethylamine_N-oxide + 2 ferricytochrome_c + 2 H+ 1.7.2.3 trimethylamine-N-oxide reductase

5-methylmaleylacetate + NADH + H+ <=> 2-methyl-3-oxoadipate + NAD+ 1.3.1.32 maleylacetate reductase

resorcinol + FADH2 + O2 <=> Hydroxyquinol + FAD + H2O + H+ 1.14.14.27 resorcinol 4-hydroxylase (FADH2)

2-Aminophenol + O2 <=> 2-aminomuconate_6-semialdehyde 1.13.11.74 2-aminophenol 1,6-dioxygenase

L-homoserine + NADP+ <=> L-aspartate_4-semialdehyde + NADPH + H+ 1.1.1.3 homoserine dehydrogenase

D-glyceraldehyde_3-phosphate + NAD+ + H2O <=> 3-phospho-D-glycerate + NADH + H+ 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
1.2.1.9 glyceraldehyde-3-phosphate dehydrogenase (NADP+)
1.2.1.90 glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]






4-methyl-5-nitrocatechol + O2 + NADH <=> H+ + 2-hydroxy-5-methylquinone + NAD+ + nitrite + H2O 1.14.13.210 4-methyl-5-nitrocatechol 5-monooxygenase

2-keto-3-deoxy_phosphogluconate <=> D-glyceraldehyde_3-phosphate + pyruvate 4.1.2.14 2-dehydro-3-deoxy-phosphogluconate aldolase
4.1.2.20 2-dehydro-3-deoxyglucarate aldolase
4.1.2.51 2-dehydro-3-deoxy-D-gluconate aldolase
4.1.2.55 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase




6-phosphogluconate + NAD+ <=> D-ribulose_5-phosphate + CO2 + NADH 1.1.1.343 phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating)
1.1.1.351 phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]
1.1.1.44 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)



pyridoxamine + 2-oxoglutarate <=> pyridoxal + D-glutamate 2.6.1.31 pyridoxamine---oxaloacetate transaminase
2.6.1.54 pyridoxamine-phosphate transaminase


L-lysine <=> (3R)-3-methyl-D-ornithine 5.4.99.58 methylornithine synthase

(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+ <=> 1,2-dihydroxynaphthalene + NADH + H+ 1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase

2,3-dihydroxynaphthalene <=> salicylate not assigned

beta-D-glucose_6-phosphate + NAD+ <=> 6-phospho-D-glucono-1,5-lactone + NADH + H+ 1.1.1.363 glucose-6-phosphate dehydrogenase [NAD(P)+]
1.1.1.388 glucose-6-phosphate dehydrogenase (NAD+)


4-(hydroxymethyl)benzenesulfonate + NAD+ <=> 4-formylbenzenesulfonate + H+ + NADH 1.1.1.257 4-(hydroxymethyl)benzenesulfonate dehydrogenase

cis,cis-tetrachloromuconic_acid <=> 2,3,5-Trichlorodienelactone + Hydrochloric_acid 5.5.1.7 chloromuconate cycloisomerase

5,10-methylenetetrahydromethanopterin + NADP+ <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH 1.5.1

3,4-dihydroxybenzoate + NH3 <=> 4-Aminobenzoic_acid + O2 + 2 H+ 1.14.12

4-Isopropylbenzyl_alcohol + NAD+ <=> cuminaldehyde + NADH + H+ 1.1.1.90 aryl-alcohol dehydrogenase
1.1.1.M33


(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD+ <=> catechol + CO2 + NADH 1.3.1.25 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase

2-naphthoic_acid <=> 5,6,7,8-Tetrahydro-2-naphthoic_acid not assigned

4-Aminophenol + H2O <=> 1,4-benzoquinone + NH3 1.4

H+ + 4-hydroxyphenylglyoxylate <=> 4-hydroxybenzaldehyde + CO2 4.1.1.7 benzoylformate decarboxylase

4-hydroxylamino-2,6-dinitrotoluene + 2 NADPH + 2 H+ <=> 2,4-Dihydroxylamino-6-nitrotoluene + 2 NADP+ + H2O 1.7.1

L-Fuculose + ATP <=> H+ + L-Fuculose_1-phosphate + ADP 2.7.1.51 L-fuculokinase

dihydroxyacetone_phosphate <=> methylglyoxal + phosphate 4.1.2.17 L-fuculose-phosphate aldolase
4.2.3.3 methylglyoxal synthase
5.3.1.1 triose-phosphate isomerase



1-(4'-hydroxyphenyl)ethanol + NAD+ <=> 4-hydroxyacetophenone + NADH + H+ 1.1.1
1.1.1.311 (S)-1-phenylethanol dehydrogenase
1.1.1.B3
1.14.13.84 4-hydroxyacetophenone monooxygenase




trans-3-Chloroallyl_aldehyde + H2O <=> trans-3-Chloroacrylic_acid + 2 H+ 1.2.1.3 aldehyde dehydrogenase (NAD+)

dihomocitrate + CoA + H+ <=> 2-oxoadipate + acetyl-CoA + H2O 2.3.3
4.1.3


2-naphthalenemethanol + O2 + NADH + H+ <=> cis-1,2-Dihydroxy-1,2-dihydro-7-hydroxymethylnaphthalene + NAD+ 1.14.12.12 naphthalene 1,2-dioxygenase

aminohydroquinone + H2O <=> Hydroxyquinol + NH3 not assigned

6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD+ <=> H+ + 6-oxocyclohex-1-ene-1-carbonyl-CoA + NADH 1.1.1.368 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase

(2R)-3-sulfolactate + NAD+ <=> H+ + 3-sulfopyruvate + NADH 1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.37 malate dehydrogenase
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]



2-Amino-4-nitrotoluene + 3 NADPH + 3 H+ <=> 2,4-Diaminotoluene + 3 NADP+ + 2 H2O 1.7.1

O-acetyl-L-serine + Sulfide <=> L-cysteine + acetate + H+ 2.5.1.47 cysteine synthase
2.5.1.49 O-acetylhomoserine aminocarboxypropyltransferase
2.5.1.65 O-phosphoserine sulfhydrylase
4.2.1.22 cystathionine beta-synthase
4.2.1.50 pyrazolylalanine synthase
4.4.1.9 L-3-cyanoalanine synthase






(R)-2-methylmalonyl-CoA <=> succinyl-CoA 5.4.99.2 methylmalonyl-CoA mutase
5.4.99.63 ethylmalonyl-CoA mutase
5.4.99.64 2-hydroxyisobutanoyl-CoA mutase



3,5-dibromo-4-hydroxybenzoic_acid <=> 2,6-dibromophenol not assigned

(2E,4Z)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O <=> 2-hydroxy-2,4-pentadienoate + succinate 3.7.1.14 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase

sulfite + 2 ferricytochrome_c + H2O <=> sulfate + 2 ferricytochrome_c + 2 H+ 1.8.2.1 sulfite dehydrogenase (cytochrome)
1.8.3.1 sulfite oxidase


5-Oxopentanoate + H2O + NAD+ <=> Glutarate + NADH + H+ 1.2.1.20 glutarate-semialdehyde dehydrogenase
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase


trimethylamine + O2 + NADPH <=> Trimethylamine_N-oxide + H2O + NADP+ 1.14.13.148 trimethylamine monooxygenase
1.14.13.8 flavin-containing monooxygenase


5-Fluorocyclohexadiene-cis,cis-1,2-diol-1-carboxylate + NAD+ <=> 4-Fluorocatechol + NADH + CO2 + H+ 1.3.1.25 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase

3-hydroxypimeloyl-CoA + NAD+ <=> H+ + NADH + 3-oxopimeloyl-CoA 1.1.1.259 3-hydroxypimeloyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase


2,2'',3-Trihydroxy-3''-methoxy-5,5''-dicarboxybiphenyl + O2 <=> 4-[2-(5-Carboxy-2-hydroxy-3-methoxyphenyl)-2-oxoethylidene]-2-hydroxy-2-pentenedioate not assigned

4-fluoro-2-hydro-1,2-dihydroxybenzoate + NAD+ <=> 4-Fluorocatechol + NADH + CO2 + H+ 1.3.1.25 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase

oxaloacetate + GTP <=> CO2 + phosphoenolpyruvate + GDP 4.1.1.32 phosphoenolpyruvate carboxykinase (GTP)
4.1.1.49 phosphoenolpyruvate carboxykinase (ATP)


benzo[a]pyrene + O2 <=> Benzo[a]pyrene-11,12-epoxide 1.14

4-Fluorobenzoate + NADH + H+ + O2 <=> 4-fluoro-2-hydro-1,2-dihydroxybenzoate + NAD+ 1.14.12.10 benzoate 1,2-dioxygenase

3-hydroxy-cis,cis-muconate <=> maleylacetate 0.0.0.0

Sulfide + 2 ferricytochrome_c <=> sulfur + 2 ferricytochrome_c + 2 H+ 1.8.2.3 sulfide-cytochrome-c reductase (flavocytochrome c)

cis-4-carboxymethylenebut-2-en-4-olide + H2O <=> maleylacetate + H+ 3.1.1.45 carboxymethylenebutenolidase

D-glyceraldehyde + H2O + NADP+ <=> D-glycerate + NADPH + H+ 1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.26 2,5-dioxovalerate dehydrogenase
1.2.1.4 aldehyde dehydrogenase (NADP+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.8 betaine-aldehyde dehydrogenase
1.2.1.89 D-glyceraldehyde dehydrogenase (NADP+)






ATP + 4-Fluorobenzoate + CoA <=> AMP + diphosphate + 4-fluorobenzoyl-CoA 6.2.1.25 benzoate---CoA ligase
6.2.1.27 4-hydroxybenzoate---CoA ligase
6.2.1.32 anthranilate---CoA ligase
6.2.1.33 4-chlorobenzoate---CoA ligase




2-ketocyclohexane-1-carboxyl-CoA + H2O <=> H+ + pimeloyl-CoA 3.1.2
3.7.1


trihomocitrate <=> (-)-threo-iso(homo)3citrate 4.2.1.114 methanogen homoaconitase

trans-3-[(5S,6R)-5,6-dihydroxycyclohexa-1,3-dienyl]-acrylic_acid + NAD+ <=> (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NADH + H+ 1.3.1.87 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase

5,6,7,8-Tetrahydro-2-naphthoic_acid <=> cis-2-Carboxycyclohexyl-acetic_acid not assigned

Pyrene-1,2-oxide <=> 1-hydroxypyrene not assigned

H+ + Phosphonopyruvate <=> phosphonoacetaldehyde + CO2 4.1.1.82 phosphonopyruvate decarboxylase

Benzo[a]pyrene-cis-11,12-dihydrodiol <=> 11,12-Dihydroxybenzo[a]pyrene 1.3

Thiobenzamide_S,S-dioxide <=> Benzonitrile not assigned

2-Pyrone-4,6-dicarboxylate + H2O <=> 4-oxalomesaconate + H+ 3.1.1.57 2-pyrone-4,6-dicarboxylate lactonase

H+ + anthranilate + O2 + NADPH <=> NH3 + NADP+ + 2,3-Dihydroxybenzoate 1.14.13.35 anthranilate 3-monooxygenase (deaminating)

2-methylnaphthalene + O2 + NADH + H+ <=> 2-naphthalenemethanol + NAD+ + H2O 1.14.13

5-chloro-2-hydroxy-[1,4]-benzoquinone + NADH <=> 5-chloro-1,2,4-trihydroxybenzene + NAD+ 1.6.5.7 2-hydroxy-1,4-benzoquinone reductase

Caffeine + O2 + NADPH + H+ <=> theophylline + formaldehyde + NADP+ + H2O 1.13.12
1.14.13.128 7-methylxanthine demethylase


H+ + melilotate + O2 + NADH <=> 3-(2,3-dihydroxyphenyl)propanoate + H2O + NAD+ 1.14.13.4 melilotate 3-monooxygenase

N6-acetyl-N6-hydroxy-L-lysine + citrate + ATP <=> N2-citryl-N6-acetyl-N6-hydroxy-L-lysine + AMP + diphosphate + H+ 6.3.2.38 N2-citryl-N6-acetyl-N6-hydroxylysine synthase

H+ + L-glutamate <=> CO2 + 4-aminobutanoate 4.1.1.15 glutamate decarboxylase
4.1.1.25 tyrosine decarboxylase
4.1.1.29 sulfinoalanine decarboxylase



D-glyceraldehyde + acceptor + H2O <=> D-glycerate + reduced_acceptor + H+ 1.2.99.8 glyceraldehyde dehydrogenase (FAD-containing)

1,2,4-trichlorobenzene + O2 + NADH + H+ <=> 3,4,6-Trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene + NAD+ 1.14.12.26 chlorobenzene dioxygenase

2,3,6-Trihydroxypyridine + O2 + H+ <=> Maleamate + 2 H+ + CO2 not assigned

NH3 + H2O + NAD+ <=> nitrite + NADH + H+ 1.7.1.10 hydroxylamine reductase (NADH)
1.7.1.15 nitrite reductase (NADH)
1.7.1.4 nitrite reductase [NAD(P)H]



4-Fluorocatechol + O2 <=> 3-fluoro-cis,cis-muconate 1.13.11.1 catechol 1,2-dioxygenase

D-chiro-Inositol + NAD+ <=> 2D-2,3,5/4,6-pentahydroxycyclohexanone + NADH + H+ 1.1.1.18 inositol 2-dehydrogenase
1.1.1.369 D-chiro-inositol 1-dehydrogenase


chlorobenzene + O2 + NADH + H+ <=> cis-1,2-dihydrobenzene-3-chloro-(R,R)-1,2-diol + NAD+ 1.14.12.26 chlorobenzene dioxygenase

(4S)-(+)-muconolactone <=> H+ + cis,cis-muconate 5.5.1.1 muconate cycloisomerase

(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O <=> H+ + anthranilate + 2-hydroxy-2,4-pentadienoate 3.7.1.13 2-hydroxy-6-oxo-6-(2-aminophenyl)hexa-2,4-dienoate hydrolase

4-amino-2,6-dinitrotoluene + 3 NADH + 3 H+ <=> 2,4-Diamino-6-nitrotoluene + 3 NAD+ + 2 H2O 1.7.1

CoA + acetate + ATP <=> phosphate + acetyl-CoA + ADP 6.2.1.1 acetate---CoA ligase
6.2.1.13 acetate---CoA ligase (ADP-forming)
6.2.1.B11



L-Rhamnofuranose + NAD+ <=> L-Rhamno-1,4-lactone + NADH + H+ 1.1.1.173 L-rhamnose 1-dehydrogenase
1.1.1.378 L-rhamnose 1-dehydrogenase [NAD(P)+]


Benzo[a]pyrene-trans-11,12-dihydrodiol <=> 11,12-Dihydroxybenzo[a]pyrene 1.3

fluorene + O2 + NADH + H+ <=> 9-fluorenol + H2O + NAD+ 1.14.12
1.14.12.12 naphthalene 1,2-dioxygenase
1.14.12.22 carbazole 1,9a-dioxygenase
1.14.13




H2O + 3,5-dibromo-4-hydroxybenzonitrile <=> NH3 + 3,5-dibromo-4-hydroxybenzoic_acid 3.5.5.1 nitrilase
3.5.5.6 bromoxynil nitrilase


1,1,1-trichloroethane <=> 1,1-Dichloroethane + Hydrochloric_acid 1.97.1

2-Hydroxy-3-methylbenzalpyruvate + H2O <=> 2-hydroxy-3-methylbenzaldehyde + pyruvate 4.2.1

L-serine + acetyl-CoA <=> O-acetyl-L-serine + CoA 2.3.1.30 serine O-acetyltransferase

5-Aminopentanamide + H2O <=> 5-Aminopentanoate + NH3 3.5.1.30 5-aminopentanamidase

4-hydroxyphenylacetate + O2 + NADH + H+ <=> homogentisate + H2O + NAD+ 1.14.13.18 4-hydroxyphenylacetate 1-monooxygenase

1,2,3,5-Tetrahydroxybenzene + pyrogallol <=> 1,2,3,5-Tetrahydroxybenzene + phloroglucinol 1.97.1.2 pyrogallol hydroxytransferase

tetrachlorocatechol + O2 <=> cis,cis-tetrachloromuconic_acid 1.13.11.1 catechol 1,2-dioxygenase

cyclohexanone + NADPH + H+ + O2 <=> epsilon-caprolactone + NADP+ + H2O 1.14.13.16 cyclopentanone monooxygenase
1.14.13.22 cyclohexanone monooxygenase
1.14.13.92 phenylacetone monooxygenase



H+ + 3-sulfomuconate <=> 4-sulfomuconolactone 5.5.1
5.5.1.2 3-carboxy-cis,cis-muconate cycloisomerase


1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane <=> H+ + 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + Cl- 4.5.1.1 DDT-dehydrochlorinase

D-fructose_1,6-bisphosphate + H2O <=> beta-D-fructose_6-phosphate + phosphate 3.1.3.11 fructose-bisphosphatase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.37 sedoheptulose-bisphosphatase
3.1.3.7 3'(2'),5'-bisphosphate nucleotidase




Cl- + hydroquinone + GSSG + H+ <=> chlorohydroquinone + glutathione 2.5.1

L-glutamate + oxidized_ferredoxin <=> 2-oxoglutarate + L-glutamine + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.4.7.1 glutamate synthase (ferredoxin)

1,2-Dihydroxy-8-methylnaphthalene + O2 <=> 2-Hydroxy-8-methylchromene-2-carboxylate 1.13

5,5''-Dehydrodivanillate + O2 + NADPH + H+ <=> 2,2'',3-Trihydroxy-3''-methoxy-5,5''-dicarboxybiphenyl + NADP+ + H2O + formaldehyde not assigned

2 Atrazine + O2 <=> 2 deisopropylatrazine + 2 acetone 1.14.15

1-Hydroxypyrene-7,8-oxide <=> 1,8-dihydroxypyrene not assigned

beta-methylaspartate <=> NH3 + mesaconate 4.3.1.2 methylaspartate ammonia-lyase

3-Phenylpropionic_acid <=> 3-(3-Hydroxyphenyl)propanoic_acid not assigned

H+ + Phthalate + O2 + NADH <=> Phthalate_3,4-cis-dihydrodiol + NAD+ 1.14.12

2-Amino-4-nitrotoluene + 3 NADH + 3 H+ <=> 2,4-Diaminotoluene + 3 NAD+ + 2 H2O 1.7.1

tetrahydrofolate + acetyl-CoA <=> 5-methyltetrahydrofolate + CoA + CO 2.1.1.258 5-methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase
2.3.1.169 CO-methylating acetyl-CoA synthase


(S)-ureidoglycolate + NADP+ <=> Oxalureate + NADPH + H+ 1.1.1.154 ureidoglycolate dehydrogenase

salicylate + NADPH + H+ + O2 <=> 2,5-Dihydroxybenzoate + NADP+ + H2O 1.14.13.172 salicylate 5-hydroxylase

parathion + H2O <=> H+ + diethyl_thiophosphate + 4-nitrophenol 3.1.8.1 aryldialkylphosphatase

mono(2-hydroxyethyl)_terephthalate + H2O <=> terephthalate + ethylene_glycol + H+ 3.1.1.102 mono(ethylene terephthalate) hydrolase

6-hydroxyhexanoate + NAD+ <=> H+ + 6-oxohexanoate + NADH 1.1.1.258 6-hydroxyhexanoate dehydrogenase

3-methyl-cis,cis-muconate <=> 4-Carboxymethyl-3-methylbut-2-en-1,4-olide 5.5.1.1 muconate cycloisomerase

ATP + alpha-D-glucose <=> ADP + alpha-D-glucose_6-phosphate 2.7.1.1 hexokinase
2.7.1.2 glucokinase


2,4-Dichlorophenoxyacetic_acid + H+ + 2 e- <=> 4-Chlorophenoxyacetate + Cl- 1.97.1

H2O + alpha-D-glucose_1-phosphate <=> phosphate + D-glucose 2.4.1.7 sucrose phosphorylase
3.1.3.1 alkaline phosphatase
3.1.3.10 glucose-1-phosphatase
3.1.3.11 fructose-bisphosphatase
3.1.3.2 acid phosphatase
3.1.3.23 sugar-phosphatase
3.1.3.25 inositol-phosphate phosphatase
3.1.3.26 4-phytase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.37 sedoheptulose-bisphosphatase
3.1.3.58 sugar-terminal-phosphatase
3.1.3.8 3-phytase
3.1.3.93 L-galactose 1-phosphate phosphatase
3.6.1.1 inorganic diphosphatase














3-phospho-D-glycerate + NAD+ <=> H+ + 3-phosphohydroxypyruvate + NADH 1.1.1.95 phosphoglycerate dehydrogenase

1,3,7-trimethyluric_acid + O2 + 2 H2O <=> 3,6,8-Trimethylallantoin + CO2 + H2O2 1.7.3.3 factor-independent urate hydroxylase

(1R,6S)-dihydroxycyclohexa-2,4-diene-1,4-dicarboxylate + NAD+ <=> 3,4-dihydroxybenzoate + CO2 + NADH 1.3.1.53 (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase

2,2,3-trichlorooxirane <=> formate not assigned

ATP + CoA + 4-Chlorobenzoate <=> diphosphate + AMP + 4-chlorobenzoyl-CoA 6.2.1.2 medium-chain acyl-CoA ligase
6.2.1.25 benzoate---CoA ligase
6.2.1.33 4-chlorobenzoate---CoA ligase



5-dehydro-2-deoxy-D-gluconate + ATP <=> H+ + 6-phospho-5-dehydro-2-deoxy-D-gluconate + ADP 2.7.1.92 5-dehydro-2-deoxygluconokinase

1-(6-hydroxypyrid-3-yl)-4-(methylamino)-butan-1-one + 2 H2O <=> 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + methylamine not assigned

1,2-Dihydrophthalic_acid + NAD+ <=> Phthalate + NADH + H+ 1.3.1.19 cis-1,2-dihydrobenzene-1,2-diol dehydrogenase

syringic_acid + tetrahydrofolate <=> 5-methoxygallic_acid + 5-methyltetrahydrofolate 2.1.1
2.1.1.341 vanillate/3-O-methylgallate O-demethylase


NH3 + H2O + oxidized_ferredoxin <=> nitrite + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.7.7.1 ferredoxin---nitrite reductase
1.8.7.1 assimilatory sulfite reductase (ferredoxin)


hydrazine + H2O + 3 ferricytochrome_c <=> NO + NH3 + 3 ferricytochrome_c 1.7.2.7 hydrazine synthase

6-aminohexanoate + 2-oxoglutarate <=> 6-oxohexanoate + L-glutamate 2.6.1.116
2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.2 alanine transaminase
2.6.1.48 5-aminovalerate transaminase




S-formylglutathione + H2O <=> H+ + formate + glutathione 3.1.1.56 methylumbelliferyl-acetate deacetylase
3.1.2.12 S-formylglutathione hydrolase
3.1.2.6 hydroxyacylglutathione hydrolase



trimethylamine + H2O + flavin <=> Dimethylamine + formaldehyde + reduced_flavodoxin 1.5.8.2 trimethylamine dehydrogenase

pyruvate + 2-aminoethylphosphonate <=> L-alanine + phosphonoacetaldehyde 2.6.1.18 beta-alanine---pyruvate transaminase
2.6.1.37 2-aminoethylphosphonate---pyruvate transaminase


4-toluenesulfonate + O2 <=> p-Cresol + sulfate 1.14.13

Benzo[a]pyrene-11,12-epoxide + H2O <=> Benzo[a]pyrene-trans-11,12-dihydrodiol 3.3.2

L-aspartate_4-semialdehyde + phosphate + NADP+ <=> L-4-aspartyl_phosphate + NADPH + H+ 1.2.1.11 aspartate-semialdehyde dehydrogenase

2,4,5-trichloro-2,5-cyclohexadiene-1-ol <=> 2,5-dichlorophenol + Hydrochloric_acid not assigned

1,1a-dihydroxy-1-hydrofluoren-9-one + H2O <=> 2,3-Dihydroxy-2''-carboxybiphenyl + 2 H+ 1.3

Urate + NADH + H+ + O2 <=> 5-hydroxyisourate + NAD+ + H2O 1.14.13.113 FAD-dependent urate hydroxylase