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Metabolic pathways

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
Trichloroethylene + 2 H+ <=> trans-dichloroethylene + Hydrochloric_acid 1.21.99.5 tetrachloroethene reductive dehalogenase

indole-3-glycerol_phosphate + L-serine <=> L-tryptophan + H2O + D-glyceraldehyde_3-phosphate 4.2.1.20 tryptophan synthase

S-adenosyl-L-methionine + Theobromine <=> H+ + Caffeine + S-adenosyl-L-homocysteine 2.1.1.160 caffeine synthase

(S)-3-hydroxy-3-methylglutaryl-CoA <=> H2O + trans-3-methylglutaconyl-CoA 4.2.1.18 methylglutaconyl-CoA hydratase

Avermectin_A1b_aglycone + dTDP-L-oleandrose <=> Avermectin_A1b_monosaccharide + dTDP 2.4.1

lauroyl-CoA + acetyl-CoA <=> 3-oxotetradecanoyl-CoA + CoA 2.3.1.16 acetyl-CoA C-acyltransferase

ATP + (R)-2-Aza-beta-tyrosine + pC3'p <=> AMP + diphosphate + (R)-2-Aza-beta-tyrosyl-[pcp] 6.2.1

Glutarate + 2-oxoglutarate + O2 <=> (S)-2-hydroxyglutarate + succinate + CO2 1.14.11.64 glutarate dioxygenase

(S)-4-(3''-acetyl-5''-hydroxy-4''-oxo-1,4''-dihydronapthalen-2''-yl)-3-hydroxybutanoate <=> 2-((1R,3S),-1,9''-dihydroxy-1''-methyl-10''-oxo-3,4,5,10''-tetrahydro-1H-benzo[g]isochromen-3''-yl)acetate 5.5.1

7-hydroxychlorophyllide_a + O2 + NADPH + H+ <=> chlorophyllide_b + 2 H2O + NADP+ 1.14.13.122 chlorophyllide-a oxygenase

NH3 + NADP+ + H2O <=> nitrite + NADPH + H+ 1.7.1.4 nitrite reductase [NAD(P)H]
1.7.7.1 ferredoxin---nitrite reductase
1.8.1.2 assimilatory sulfite reductase (NADPH)



L-cystine + glutathione <=> GSSG + L-cysteine 1.8.1.6 cystine reductase
1.8.4.4 glutathione---cystine transhydrogenase
1.8.4.9 adenylyl-sulfate reductase (glutathione)



FMNH2 + NAD+ <=> FMN + NADH + H+ 1.14.13.7 phenol 2-monooxygenase (NADPH)
1.18.1.4 rubredoxin---NAD(P)+ reductase
1.5.1
1.5.1.30 flavin reductase (NADPH)
1.5.1.36 flavin reductase (NADH)
1.5.1.37 FAD reductase (NADH)
1.5.1.38 FMN reductase (NADPH)
1.5.1.39 FMN reductase [NAD(P)H]
1.5.1.41 riboflavin reductase [NAD(P)H]
1.5.1.42 FMN reductase (NADH)










Cys-Gly + H2O <=> L-cysteine + glycine 3.4.11.1 leucyl aminopeptidase
3.4.11.10 bacterial leucyl aminopeptidase
3.4.11.2 membrane alanyl aminopeptidase
3.4.11.23 PepB aminopeptidase
3.4.11.6 aminopeptidase B
3.4.13
3.4.13.18 cytosol nonspecific dipeptidase
3.4.13.23








1-hydroxy-2-naphthaldehyde + pyruvate <=> (3E)-4-(1-hydroxynaphthalen-2-yl)-2-oxobut-3-enoate + H2O 4.1.2
4.1.2.45 trans-o-hydroxybenzylidenepyruvate hydratase-aldolase


H2O + N-Acetyl-D-galactosamine_6-phosphate <=> D-galactosamine_6-phosphate + acetate 3.5.1.25 N-acetylglucosamine-6-phosphate deacetylase

D-glycero-beta-D-manno-heptose_1,7-bisphosphate + H2O <=> D-glycero-beta-D-manno-heptose_1-phosphate + phosphate 3.1.3.82 D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase

homocarnosine + H2O <=> 4-aminobutanoate + L-histidine 3.4.13.18 cytosol nonspecific dipeptidase
3.4.13.20 beta-Ala-His dipeptidase
3.4.13.5 Xaa-methyl-His dipeptidase



UDP-N-acetyl-D-galactosamine + paragloboside <=> UDP + PX2 2.4.1.79 globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase

aurachin_C + O2 + NADH + H+ <=> 4-hydroxy-2-methyl-4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]quinolin-3(4H)-one_1-oxide + NAD+ + H2O 1.14.13.222 aurachin C monooxygenase/isomerase

3-hydroxyisovaleryl-CoA <=> 3-methylcrotonoyl-CoA + H2O 4.2.1.17 enoyl-CoA hydratase

CMP-2-aminoethylphosphonate + ceramide <=> Ceramide_2-aminoethylphosphonate + CMP 2.7.8

melibiose + H2O <=> D-galactose + D-glucose 3.2.1.22 alpha-galactosidase
3.2.1.28 alpha,alpha-trehalase


Leucocyanidin + NADP+ <=> taxifolin + NADPH + H+ 1.1.1.219 dihydroflavonol 4-reductase

19-hydroxytestosterone + O2 + flavin_hydroquinone <=> 19-oxotestosterone + 2 H2O + [oxidized_NADPH-hemoprotein_reductase] 1.14.14.14 aromatase

1-hydroxylycopene + acceptor <=> 1-hydroxy-3,4-didehydrolycopene + reduced_acceptor 1.3.99.27 1-hydroxycarotenoid 3,4-desaturase
1.3.99.30 phytoene desaturase (3,4-didehydrolycopene-forming)
1.3.99.37 1-hydroxy-2-isopentenylcarotenoid 3,4-desaturase



vitamin_D3 + reduced_ferredoxin_[iron-sulfur]_cluster + O2 + H+ <=> 25-hydroxyvitamin_D3 + oxidized_ferredoxin + H2O 1.14.15.22 vitamin D 1,25-hydroxylase

tetradecanoyl-[acyl-carrier_protein] + Stearoyl-KDO2-lipid_IVA <=> H._pylori_KDO2-lipid_A + [acyl-carrier_protein] 2.3.1

XMP + H2O <=> Xanthosine + phosphate 3.1.3.5 5'-nucleotidase

ATP + protoporphyrin_IX + Mg2+ + H2O <=> H+ + magnesium_protoporphyrin_IX + phosphate + ADP 6.6.1.1 magnesium chelatase

(R)-3-hydroxydodecanoyl-[acyl-carrier_protein] + NADP+ <=> 3-oxododecanoyl-[acyl-carrier_protein] + NADPH + H+ 1.1.1
1.1.1.100 3-oxoacyl-[acyl-carrier-protein] reductase
2.3.1
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system





3,5,7,9,11,13,15-Heptaoxo-hexadecanoyl-[acp] <=> 7,9,12-Octaketide_intermediate_1 not assigned

UDP-glucose + validoxylamine_A <=> validamycin_A + UDP + H+ 2.4.1.338 validoxylamine A glucosyltransferase

L-homoserine + succinyl-CoA <=> O-succinyl-L-homoserine + CoA 2.3.1.46 homoserine O-succinyltransferase

7alpha,12alpha-dihydroxy-4-cholesten-3-one + NADPH + H+ <=> 7alpha,12alpha-dihydroxy-5beta-cholestan-3-one + NADP+ 1.3.1.3 Delta4-3-oxosteroid 5beta-reductase

2-Chloroethanol + 2 ferricytochrome_c <=> Chloroacetaldehyde + 2 ferricytochrome_c + 2 H+ 1.1.2.8 alcohol dehydrogenase (cytochrome c)

2-Aminophenol + O2 <=> Isophenoxazine + H2O 1.10.3.4 o-aminophenol oxidase

catechol + O2 <=> H+ + cis,cis-muconate 1.13.11.1 catechol 1,2-dioxygenase
1.13.11.3 protocatechuate 3,4-dioxygenase
1.13.11.37 hydroxyquinol 1,2-dioxygenase



dihydroceramide + H2O <=> sphinganine + fatty_acid 3.5.1.23 ceramidase

S-adenosyl-L-methionine + epinephrine <=> metanephrine + S-adenosyl-L-homocysteine + H+ 2.1.1.6 catechol O-methyltransferase

cobalt-factor_III <=> cobalt-precorrin-3B not assigned

N-Acetyl-L-Asp-L-Glu + H2O <=> N-acetyl-L-aspartate + L-glutamate 3.4.17.21 glutamate carboxypeptidase II

3-Hydroxy-OPC6-CoA + NAD+ <=> 3-Oxo-OPC6-CoA + NADH + H+ 1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
1.1.1.35 3-hydroxyacyl-CoA dehydrogenase


Dimethylamine + H2O + flavin <=> methylamine + formaldehyde + reduced_flavodoxin 1.5.8.1 dimethylamine dehydrogenase

UDP-N-acetylmannosamine + NAD+ + H2O <=> UDP-N-acetyl-alpha-D-mannosaminuronate + NADH + H+ 1.1.1.336 UDP-N-acetyl-D-mannosamine dehydrogenase

L-pipecolic_acid + NADP+ <=> DELTA1-piperideine-2-carboxylate + NADPH + H+ 1.5.1.1 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]
1.5.1.21 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH)
1.5.1.25 thiomorpholine-carboxylate dehydrogenase
1.5.1.49 1-pyrroline-2-carboxylate reductase [NAD(P)H]




5-epi-Valiolol_7-phosphate <=> 1-epi-valienol_7-phosphate not assigned

CDP + ATP <=> CTP + ADP 2.7.4.3 adenylate kinase
2.7.4.6 nucleoside-diphosphate kinase


L-galactose + NADP+ <=> L-galactono-1,5-lactone + NADPH + H+ 1.1.1
1.1.1.116 D-arabinose 1-dehydrogenase (NAD+)
1.1.1.B35



D-galactosamine + protein_Npi-phospho-L-histidine <=> D-galactosamine_6-phosphate + protein_L-histidine 2.7.1

D-xylose + NADP+ <=> D-xylono-1,5-lactone + NADPH + H+ 1.1.1.179 D-xylose 1-dehydrogenase (NADP+)
1.1.1.376 L-arabinose 1-dehydrogenase [NAD(P)+]
1.1.1.47 glucose 1-dehydrogenase [NAD(P)+]
1.1.1.B35




5-methyltetrahydrosarcinapterin + coenzyme_M + 2 Sodium_cation(in) <=> tetrahydrosarcinapterin + methyl-CoM + 2 Sodium_cation(out) 2.1.1.86 tetrahydromethanopterin S-methyltransferase

oxaloacetate + H+ + Na+ <=> pyruvate + CO2 + Na+ 7.2.4.2 oxaloacetate decarboxylase (Na+ extruding)

formaldehyde + H2O <=> methanol + formate + H+ 1.2.98.1 formaldehyde dismutase

trans-4-hydroxy-L-proline + NADP+ <=> NADPH + L-1-pyrroline-3-hydroxy-5-carboxylate + H+ 1.5.1.2 pyrroline-5-carboxylate reductase

ascorbate <=> ascorbate + dehydroascorbate + H+ 1.11.1.11 L-ascorbate peroxidase

GTP + H2O <=> H+ + 2-amino-5-formylamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + phosphate 3.5.4.29 GTP cyclohydrolase IIa

dolichyl_phosphate_D-mannose + protein <=> dolichyl_phosphate + alpha-D-Man-1-Ser/Thr 2.4.1.109 dolichyl-phosphate-mannose---protein mannosyltransferase

vitamin_D3 + O2 + flavin_hydroquinone <=> 25-hydroxyvitamin_D3 + [oxidized_NADPH-hemoprotein_reductase] + H2O 1.14.14.24 vitamin D 25-hydroxylase

(S)-malate + NADP+ <=> pyruvate + CO2 + NADPH 1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating)
1.1.1.39 malate dehydrogenase (decarboxylating)
1.1.1.40 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
1.1.1.85 3-isopropylmalate dehydrogenase




alpha-amino-beta-carboxymuconate-epsilon-semialdehyde <=> quinolinic_acid + H2O not assigned

tetradecanoyl-[acyl-carrier_protein] + NADP+ <=> trans-Tetradec-2-enoyl-[acp] + NADPH + H+ 1.3.1
1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)
1.3.1.104 enoyl-[acyl-carrier-protein] reductase (NADPH)
1.3.1.39 enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)
2.3.1.85 fatty-acid synthase system
2.3.1.86 fatty-acyl-CoA synthase system






Dolichyl_D-glucosyl_phosphate + alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> dolichyl_phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol 2.4.1.265 dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichol alpha-1,3-glucosyltransferase

delta-carotene <=> alpha-carotene 5.5.1.19 lycopene beta-cyclase

L-4-hydroxyglutamate_semialdehyde + NAD+ + H2O <=> L-erythro-4-hydroxyglutamate + NADH + H+ 1.2.1
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase


ATP + AMP <=> ADP 1.13.12.7 firefly luciferase
2.7.1.20 adenosine kinase
2.7.4.10 nucleoside-triphosphate---adenylate kinase
2.7.4.11 (deoxy)adenylate kinase
2.7.4.14 UMP/CMP kinase
2.7.4.3 adenylate kinase
2.7.4.31 [5-(aminomethyl)furan-3-yl]methyl phosphate kinase
2.7.4.8 guanylate kinase
2.7.4.9 dTMP kinase









S-adenosyl-L-methionine + Pretetramid <=> S-adenosyl-L-homocysteine + 6-methylpretetramide + H+ 2.1.1
2.1.1.M31


S-adenosyl-L-methionine + cobalt-precorrin-7 <=> cobalt-precorrin-8 + S-adenosyl-L-homocysteine 2.1.1.289 cobalt-precorrin-7 (C5)-methyltransferase

phenylacetaldehyde + NADP+ + H2O <=> phenylacetate + NADPH + H+ 1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.39 phenylacetaldehyde dehydrogenase
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.8 betaine-aldehyde dehydrogenase




Hypotaurine + H2O + NAD+ <=> taurine + NADH + H+ 1.8.1.3 hypotaurine dehydrogenase

2-hydroxy-6-oxoocta-2,4-dienoate + H2O <=> 2-hydroxy-2,4-pentadienoate + propionate 3.7.1

CTP + phosphatidic_acid + H+ <=> CDP-diacylglycerol + diphosphate 2.7.7.41 phosphatidate cytidylyltransferase

L-erythro-3,5-diaminohexanoate + NAD+ + H2O <=> H+ + (S)-5-amino-3-oxohexanoate + NH3 + NADH 1.4.1.11 L-erythro-3,5-diaminohexanoate dehydrogenase

NH3 + IMP + NADP+ <=> H+ + GMP + NADPH 1.7.1.7 GMP reductase

L-lactaldehyde + NADP+ <=> methylglyoxal + NADPH + H+ 1.1.1.156 glycerol 2-dehydrogenase (NADP+)
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.21 aldehyde reductase
1.1.1.283 methylglyoxal reductase (NADPH)
1.1.1.71 alcohol dehydrogenase [NAD(P)+]
1.1.1.72 glycerol dehydrogenase (NADP+)
1.1.1.78 methylglyoxal reductase (NADH)
1.2.1.49 2-oxoaldehyde dehydrogenase (NADP+)








Toluene + O2 + NADH + H+ <=> (1S,2R)-3-Methylcyclohexa-3,5-diene-1,2-diol + NAD+ 1.14.12.11 toluene dioxygenase

(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate <=> (Z)-2-methylaconitate + H2O 4.2.1.3 aconitate hydratase
4.2.1.99 2-methylisocitrate dehydratase


(1R,2S,5S,6S)-2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate <=> (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate + pyruvate 4.2.99.20 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

dibenzo-p-dioxin + NADH + O2 <=> 2,2'',3-trihydroxybiphenyl_ether + NAD+ 1.14.12
1.14.12.18 biphenyl 2,3-dioxygenase
1.14.12.22 carbazole 1,9a-dioxygenase



7-deoxyloganin + flavin_hydroquinone + O2 <=> loganin + [oxidized_NADPH-hemoprotein_reductase] + H2O 1.14.14.85 7-deoxyloganate 7-hydroxylase

glucobrassicin + H2O <=> indole-3-acetonitrile + D-glucose + sulfate + sulfur 3.2.1.147 thioglucosidase

D-glyceraldehyde_3-phosphate + NADP+ + H2O <=> H+ + 3-phospho-D-glycerate + NADPH 1.2.1.89 D-glyceraldehyde dehydrogenase (NADP+)
1.2.1.9 glyceraldehyde-3-phosphate dehydrogenase (NADP+)
1.2.1.90 glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]



IMP + H2O <=> Inosine + phosphate 3.1.3.1 alkaline phosphatase
3.1.3.2 acid phosphatase
3.1.3.31 nucleotidase
3.1.3.5 5'-nucleotidase
3.1.3.99 IMP-specific 5'-nucleotidase





CoA + acetoacetate + ATP <=> acetoacetyl-CoA + diphosphate + AMP 6.2.1.16 acetoacetate---CoA ligase

H+ + Dihydroxyfumarate <=> CO2 + tartronate_semialdehyde 4.1.1.54 dihydroxyfumarate decarboxylase

3,5,7,9,11,13,15,17,19-Nonaoxo-eicosanoyl-[acp] <=> 9,14-Decaketide_intermediate_1 + 2 H2O 2.3.1.235 tetracenomycin F2 synthase
4.2.1


(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + reduced_adrenodoxin + O2 + H+ <=> 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic_acid + oxidized_ferredoxin + H2O 1.14.15.15 cholestanetriol 26-monooxygenase
1.2.1.40 3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase


O2 + H2O + pyridoxal <=> H+ + H2O2 + 4-pyridoxate 1.2.3.1 aldehyde oxidase
1.2.3.8 pyridoxal oxidase


S-adenosyl-L-methionine + cytosine_(in_DNA) <=> 5-methylcytosine_in_DNA + S-adenosyl-L-homocysteine + H+ 2.1.1.37 DNA (cytosine-5-)-methyltransferase

2-polyprenyl-6-methoxyphenol + O2 <=> 2-Polyprenyl-6-methoxy-1,4-benzoquinone + H2O 1.14.13

(RS)-nicotine + O2 <=> N-methylmyosmine + H2O2 1.5.3

amylose <=> glycogen 2.4.1.18 1,4-alpha-glucan branching enzyme
2.4.1.25 4-alpha-glucanotransferase
3.2.1.1 alpha-amylase
3.2.1.116 glucan 1,4-alpha-maltotriohydrolase
3.2.1.133 glucan 1,4-alpha-maltohydrolase
3.2.1.135 neopullulanase
3.2.1.41 pullulanase
3.2.1.54 cyclomaltodextrinase
3.2.1.68 isoamylase









4-hydroxy-4-methyl-2-oxoglutarate <=> pyruvate 4.1.3.17 4-hydroxy-4-methyl-2-oxoglutarate aldolase

P1,P4-bis(5''-xanthosyl)_tetraphosphate + H2O <=> XTP + XMP 3.6.1.17 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)

paraxanthine <=> 1,7-dimethyluric_acid 1.14.13
1.14.14.1 unspecific monooxygenase


GDP + ATP <=> GTP + ADP 2.7.4.6 nucleoside-diphosphate kinase
2.7.4.8 guanylate kinase


4''-chloro-2,3-dihydroxybiphenyl + O2 <=> 2-hydroxy-6-oxo-6-(4''-chlorophenyl)-hexa-2,4-dienoate + H2O 1.13.11.39 biphenyl-2,3-diol 1,2-dioxygenase

3-hydroxycinnamic_acid + O2 + NADH + H+ <=> (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + H2O + NAD+ 1.14.13.127 3-(3-hydroxyphenyl)propanoate hydroxylase

(25S)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA <=> trihydroxycoprostanoyl-CoA 5.1.99.4 alpha-methylacyl-CoA racemase

Zymosterol + NADP+ <=> H+ + zymosterone + NADPH 1.1.1.270 3beta-hydroxysteroid 3-dehydrogenase
1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62 17beta-estradiol 17-dehydrogenase



geranylgeranyl_diphosphate + homogentisate + H+ <=> diphosphate + 6-geranylgeranyl-2-methylbenzene-1,4-diol + CO2 2.5.1.115 homogentisate phytyltransferase
2.5.1.116 homogentisate geranylgeranyltransferase


6-hydroxycyclohex-1-ene-1-carbonyl-CoA <=> cyclohexa-1,5-diene-1-carbonyl-CoA + H2O 4.2.1.100 cyclohexa-1,5-dienecarbonyl-CoA hydratase

Gibberellin_A24 <=> gibberellin_a9 + CO2 1.14.11.12 gibberellin-44 dioxygenase

5-Hydroxykynurenamine + CO2 <=> 5-hydroxy-L-kynurenine 4.1.1.28 aromatic-L-amino-acid decarboxylase

2 ascorbate + O2 <=> 2 dehydroascorbate + 2 H2O 1.10.3.3 L-ascorbate oxidase

(1''S,5''S)-hydroxyaverantin + NAD+ <=> H+ + 5''-oxoaverantin + NADH 1.1.1.352 5'-hydroxyaverantin dehydrogenase

1,3-dicarboxyurea + H+ <=> allophanate + CO2 not assigned

Avermectin_B1b_monosaccharide + dTDP-L-oleandrose <=> avermectin_B1b + dTDP 2.4.1

phosphoenolpyruvate + CO2 <=> phosphate + oxaloacetate 4.1.1.31 phosphoenolpyruvate carboxylase

UDP-glucose + rhodopsin <=> UDP + beta-D-Glucoside 2.4.1.35 phenol beta-glucosyltransferase

trans-3-chloroacrylate <=> malonate_semialdehyde + Cl- 3.8.1
5.3.2.1 phenylpyruvate tautomerase


2-sulfoacetaldehyde <=> coenzyme_M not assigned

dTTP + H2O <=> dTMP + diphosphate + H+ 3.6.1.12 dCTP diphosphatase
3.6.1.23 dUTP diphosphatase
3.6.1.39 thymidine-triphosphatase
3.6.1.55 8-oxo-dGTP diphosphatase
3.6.1.65 (d)CTP diphosphatase
3.6.1.8 ATP diphosphatase
3.6.1.9 nucleotide diphosphatase







cobalt-precorrin-5A + H2O <=> H+ + cobalt-precorrin-5B + acetaldehyde 3.7.1.12 cobalt-precorrin 5A hydrolase

Hydroxyspheroidene + 2 O2 + 4 reduced_ferredoxin + 4 H+ <=> Hydroxyspheroidenone + 3 H2O + 4 oxidized_ferredoxin 1.14.15.9 spheroidene monooxygenase

alpha-D-mannose_1-phosphate <=> D-mannose_6-phosphate 5.4.2.10 phosphoglucosamine mutase
5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
5.4.2.8 phosphomannomutase



trimethylamine + 2 ferricytochrome_c + H2O <=> Trimethylamine_N-oxide + 2 ferricytochrome_c + 2 H+ 1.7.2.3 trimethylamine-N-oxide reductase

cholesterol + NAD+ <=> 7-dehydrocholesterol + NADH + H+ 1.3.1.21 7-dehydrocholesterol reductase

CMP-N-acetylneuraminate + GT1c <=> CMP + GQ1c 2.4.99

acyldihydroxyacetone_phosphate + NADPH <=> lysophosphatidic_acid + NADP+ 1.1.1.101 acylglycerone-phosphate reductase

L-homoserine + NADP+ <=> L-aspartate_4-semialdehyde + NADPH + H+ 1.1.1.3 homoserine dehydrogenase

D-glyceraldehyde_3-phosphate + NAD+ + H2O <=> 3-phospho-D-glycerate + NADH + H+ 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.5 aldehyde dehydrogenase [NAD(P)+]
1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
1.2.1.9 glyceraldehyde-3-phosphate dehydrogenase (NADP+)
1.2.1.90 glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+]






GDP-mannose <=> GDP-beta-L-galactose 5.1.3.18 GDP-mannose 3,5-epimerase

D-fructose + ATP <=> H+ + beta-D-fructose_6-phosphate + ADP 2.7.1.1 hexokinase
2.7.1.2 glucokinase
2.7.1.4 fructokinase



3,4-Dihydro-7-hydroxy-2-methylene-3-oxo-2H-1,4-benzoxazine-5-carboxylate <=> 3,4-Dihydro-7-methoxy-2-methylene-3-oxo-2H-1,4-benzoxazine-5-carboxylic_acid 2.1.1

D-tagatose_1,6-bisphosphate <=> dihydroxyacetone_phosphate + D-glyceraldehyde_3-phosphate 4.1.2.13 fructose-bisphosphate aldolase
4.1.2.40 tagatose-bisphosphate aldolase


dolichyl_phosphate_D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol <=> dolichyl_phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-1-PP-Dol 2.4.1.260 dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase

H+ + 2-C-methyl-D-erythritol_4-phosphate + CTP <=> 4-(cytidine_5''-diphospho)-2-C-methyl-D-erythritol + diphosphate 2.7.7.60 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

NDP-1-epi-valienol_7-phosphate + dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose <=> dTDP-acarviose-7-phosphate 2.4

2-keto-3-deoxy_phosphogluconate <=> D-glyceraldehyde_3-phosphate + pyruvate 4.1.2.14 2-dehydro-3-deoxy-phosphogluconate aldolase
4.1.2.20 2-dehydro-3-deoxyglucarate aldolase
4.1.2.51 2-dehydro-3-deoxy-D-gluconate aldolase
4.1.2.55 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase




6-phosphogluconate + NAD+ <=> D-ribulose_5-phosphate + CO2 + NADH 1.1.1.343 phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating)
1.1.1.351 phosphogluconate dehydrogenase [NAD(P)+-dependent, decarboxylating]
1.1.1.44 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)



validone_7-phosphate <=> validamine_7-phosphate not assigned

2-aminomuconate_6-semialdehyde + NAD+ + H2O <=> 2-aminomuconate + NADH + H+ 1.2.1.32 aminomuconate-semialdehyde dehydrogenase

alpha-L-IdoA2S-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-D-GalNAc-4-S + H2O <=> alpha-L-IdoA-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-D-GalNAc-4-S + sulfate 3.1.6.13 iduronate-2-sulfatase

CTP + N,N'-diacetyllegionaminate <=> CMP-N,N''-diacetyllegionaminate + diphosphate 2.7.7.82 CMP-N,N'-diacetyllegionaminic acid synthase

L-lysine <=> (3R)-3-methyl-D-ornithine 5.4.99.58 methylornithine synthase

L-methionine + 2-oxoglutarate <=> 4-methylsulfanyl-2-oxobutanoate + L-glutamate 2.6.1.1 aspartate transaminase
2.6.1.2 alanine transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.5 tyrosine transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.6 leucine transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase
2.6.1.73 methionine---glyoxylate transaminase
2.6.1.88 methionine transaminase









alpha-D-sedoheptulopyranose_7-phosphate <=> 2-epi-5-epi-valiolone + phosphate 4.2.3.152 2-epi-5-epi-valiolone synthase

3-methylthiopropionyl-CoA + FAD <=> 3-(methylthio)acryloyl-CoA + FADH2 1.3.8

D-galacturonate + NADH + H+ <=> L-galactonate + NAD+ 1.1.1
1.1.1.365 D-galacturonate reductase


(1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+ <=> 1,2-dihydroxynaphthalene + NADH + H+ 1.3.1.29 cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase

D-galactaro-1,4-lactone <=> 5-dehydro-4-deoxy-D-glucarate + H+ 5.5.1.27 D-galactarolactone cycloisomerase

Precorrin-6Y + NADP+ <=> precorrin-6A + NADPH + H+ 1.3.1.54 precorrin-6A reductase

UDP-N-acetyl-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)-[beta-D-GlcNAc-(1->4)-[beta-D-GlcNAc-(1->2)]-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn <=> UDP + beta-D-GlcNAc-(1->6)-[beta-D-GlcNAc-(1->2)]-alpha-D-Man-(1->6)-[beta-D-GlcNAc-(1->4)-[beta-D-GlcNAc-(1->2)]-alpha-D-Man-(1->3)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-1-Asn 2.4.1.155 alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase

2,3-dihydroxynaphthalene <=> salicylate not assigned

Premithramycin_A2' + dTDP-D-mycarose <=> Premithramycin_A3 + dTDP + H+ 2.4.1

metanephrine + H2O + O2 <=> 4-hydroxyphenyl-3-methoxyglycolaldehyde + methylamine + H2O2 1.4.3.4 monoamine oxidase

beta-D-glucose_6-phosphate + NAD+ <=> 6-phospho-D-glucono-1,5-lactone + NADH + H+ 1.1.1.363 glucose-6-phosphate dehydrogenase [NAD(P)+]
1.1.1.388 glucose-6-phosphate dehydrogenase (NAD+)


S-adenosyl-L-methionine + dTDP-4-oxo-2,6-dideoxy-D-allose <=> S-adenosyl-L-homocysteine + dTDP-3-methyl-4-oxo-2,6-dideoxy-D-glucose + H+ 2.1.1

D-xylose + NAD+ <=> D-xylono-1,5-lactone + NADH + H+ 1.1.1.121 aldose 1-dehydrogenase (NAD+)
1.1.1.122 D-threo-aldose 1-dehydrogenase
1.1.1.175 D-xylose 1-dehydrogenase
1.1.1.179 D-xylose 1-dehydrogenase (NADP+)
1.1.1.18 inositol 2-dehydrogenase
1.1.1.376 L-arabinose 1-dehydrogenase [NAD(P)+]
1.1.1.47 glucose 1-dehydrogenase [NAD(P)+]







4-hydroxybutyrate + NAD+ <=> succinate_semialdehyde + NADH + H+ 1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.21 aldehyde reductase
1.1.1.61 4-hydroxybutyrate dehydrogenase
1.1.1.79 glyoxylate reductase (NADP+)
1.1.1.B47





ATP + cob(II)yrinic_acid_a,c-diamide <=> tripolyphosphate + adenosylcobyrinic_acid_a,c-diamide 2.5.1.17 corrinoid adenosyltransferase

H+ + L-Dopachrome <=> 5,6-dihydroxyindole + CO2 not assigned

phosphatidylethanolamine + 1-dephosphorylated_Kdo2-lipid_A <=> diacylglycerol + 1-PEtN-KDO2-lipid_A 2.7.8.43 lipid A phosphoethanolamine transferase

5,10-methylenetetrahydromethanopterin + NADP+ <=> 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + NADPH 1.5.1

2''-deoxyadenosine + ATP <=> H+ + dAMP + ADP 2.7.1.113 deoxyguanosine kinase
2.7.1.145 deoxynucleoside kinase
2.7.1.20 adenosine kinase
2.7.1.21 thymidine kinase
2.7.1.74 deoxycytidine kinase
2.7.1.76 2'-deoxyadenosine kinase
2.7.1.B20







6-Deoxocastasterone + O2 + reduced_flavodoxin <=> 6alpha-Hydroxy-castasterone + H2O + flavin 1.14

4-Isopropylbenzyl_alcohol + NAD+ <=> cuminaldehyde + NADH + H+ 1.1.1.90 aryl-alcohol dehydrogenase
1.1.1.M33


arachidonic_acid + O2 + NADPH + H+ <=> (5Z,8Z,14Z)-11,12-epoxyeicosatrienoic_acid + NADP+ + H2O 1.14.13
1.14.14
1.14.14.1 unspecific monooxygenase



benzoyl-CoA + glycine <=> H+ + hippuric_acid + CoA 2.3.1.13 glycine N-acyltransferase
2.3.1.14 glutamine N-phenylacetyltransferase
2.3.1.71 glycine N-benzoyltransferase



(1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate + NAD+ <=> catechol + CO2 + NADH 1.3.1.25 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase

dADP + thioredoxin_disulfide + H2O <=> ADP + thioredoxin 1.17.4.1 ribonucleoside-diphosphate reductase
1.17.4.2 ribonucleoside-triphosphate reductase (thioredoxin)


2 ascorbate + acceptor <=> 2 dehydroascorbate + reduced_acceptor not assigned

UDP-glucose + abscisic_acid <=> beta-D-glucopyranosyl_abscisate + UDP 2.4.1.263 abscisate beta-glucosyltransferase