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L-isoleucine biosynthesis IV

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
H+ + pyruvate + 2-oxobutyrate <=> (S)-2-hydroxy-2-ethyl-3-oxobutanoate + CO2 2.2.1.6 acetolactate synthase

2R,3R-2,3-dihydroxy-3-methylpentanoate <=> (S)-3-methyl-2-oxopentanoate + H2O 4.2.1.9 dihydroxy-acid dehydratase

L-isoleucine + 2-oxoglutarate <=> L-glutamate + (S)-3-methyl-2-oxopentanoate 2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.67 2-aminohexanoate transaminase


2R,3R-2,3-dihydroxy-3-methylpentanoate + NADP+ <=> (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH + H+ 1.1.1.383 ketol-acid reductoisomerase [NAD(P)+]

2-oxobutyrate + oxidized_ferredoxin + CoA <=> propionyl-CoA + reduced_ferredoxin_[iron-sulfur]_cluster + CO2 + H+ 1.2.7.1 pyruvate synthase
1.2.7.11 2-oxoacid oxidoreductase (ferredoxin)
1.2.7.7 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)



CoA + propionate + ATP <=> propionyl-CoA + diphosphate + AMP 6.2.1.1 acetate---CoA ligase
6.2.1.17 propionate---CoA ligase
6.2.1.2 medium-chain acyl-CoA ligase
6.2.1.30 phenylacetate---CoA ligase
6.2.1.36 3-hydroxypropionyl-CoA synthase
6.2.1.44 3-(methylthio)propionyl---CoA ligase






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