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Glycine, serine and threonine metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
indole-3-glycerol_phosphate + L-serine <=> L-tryptophan + H2O + D-glyceraldehyde_3-phosphate 4.2.1.20 tryptophan synthase

S-aminomethyldihydrolipoylprotein + tetrahydrofolate <=> dihydrolipoylprotein + 5,10-methylenetetrahydrofolate + NH3 2.1.2.10 aminomethyltransferase

H+ + L-2,4-diaminobutanoate <=> 1,3-diaminopropane + CO2 4.1.1.17 ornithine decarboxylase
4.1.1.18 lysine decarboxylase
4.1.1.86 diaminobutyrate decarboxylase



L-serine <=> pyruvate + NH3 4.1.99.1 tryptophanase
4.1.99.2 tyrosine phenol-lyase
4.2.1.22 cystathionine beta-synthase
4.3.1.15 diaminopropionate ammonia-lyase
4.3.1.17 L-serine ammonia-lyase
4.3.1.18 D-serine ammonia-lyase
4.3.1.19 threonine ammonia-lyase







N,N-dimethylglycine + tetrahydrofolate + flavin <=> sarcosine + 5,10-methylenetetrahydrofolate + reduced_flavodoxin 1.5.8.4 dimethylglycine dehydrogenase

L-2-amino-3-oxobutanoate + H+ <=> aminoacetone + CO2 0.0.0.0
1.1.1.381 3-hydroxy acid dehydrogenase


S-adenosyl-L-methionine + glycine <=> S-adenosyl-L-homocysteine + N,N-dimethylglycine + H+ 2.1.1.156 glycine/sarcosine N-methyltransferase

L-serine + tetrahydrofolate <=> glycine + 5,10-methylenetetrahydrofolate + H2O 2.1.2.1 glycine hydroxymethyltransferase

H2O + Creatine <=> Urea + sarcosine 3.5.3.3 creatinase

L-homoserine + ATP <=> H+ + O-phospho-L-homoserine + ADP 2.7.1.39 homoserine kinase

L-ectoine + H2O <=> N2-acetyl-L-2,4-diaminobutanoate 3.5.4.44 ectoine hydrolase
4.2.1.108 ectoine synthase


Betaine_aldehyde + NAD+ + H2O <=> H+ + betaine + NADH 1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.21 glycolaldehyde dehydrogenase
1.2.1.24 succinate-semialdehyde dehydrogenase (NAD+)
1.2.1.3 aldehyde dehydrogenase (NAD+)
1.2.1.47 4-trimethylammoniobutyraldehyde dehydrogenase
1.2.1.8 betaine-aldehyde dehydrogenase






3-phospho-D-glycerate + NAD+ <=> H+ + 3-phosphohydroxypyruvate + NADH 1.1.1.95 phosphoglycerate dehydrogenase

glycine + acetyl-CoA <=> L-2-amino-3-oxobutanoate + CoA 2.3.1.29 glycine C-acetyltransferase

L-aspartate_4-semialdehyde + phosphate + NADP+ <=> L-4-aspartyl_phosphate + NADPH + H+ 1.2.1.11 aspartate-semialdehyde dehydrogenase

L-2,4-diaminobutanoate + acetyl-CoA <=> H+ + N4-acetyl-L-2,4-diaminobutanoate + CoA 2.3.1.178 diaminobutyrate acetyltransferase

H+ + glycine + succinyl-CoA <=> CO2 + CoA + 5-aminolevulinate 2.3.1.37 5-aminolevulinate synthase

glycine + 2-oxoglutarate <=> glyoxylate + L-glutamate 2.6.1.2 alanine transaminase
2.6.1.4 glycine transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.44 alanine---glyoxylate transaminase
2.6.1.48 5-aminovalerate transaminase
2.6.1.60 aromatic-amino-acid---glyoxylate transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase







O2 + H2O + sarcosine <=> glycine + formaldehyde + H2O2 1.5.3.1 sarcosine oxidase
1.5.3.19 4-methylaminobutanoate oxidase (formaldehyde-forming)


N2-acetyl-L-2,4-diaminobutanoate + H2O <=> L-2,4-diaminobutanoate + acetate 3.5.1.125 N2-acetyl-L-2,4-diaminobutanoate deacetylase

L-threonine <=> glycine + acetaldehyde 4.1.2.26 phenylserine aldolase
4.1.2.42 D-threonine aldolase
4.1.2.48 low-specificity L-threonine aldolase
4.1.2.5 L-threonine aldolase




choline + O2 + 2 reduced_ferredoxin + 2 H+ <=> Betaine_aldehyde + 2 H2O + 2 oxidized_ferredoxin 1.14.15.7 choline monooxygenase

(R)-1-aminopropan-2-ol + NAD+ <=> H+ + aminoacetone + NADH 1.1.1.75 (R)-aminopropanol dehydrogenase

L-threonine <=> 2-oxobutyrate + NH3 4.2.3.1 threonine synthase
4.3.1.17 L-serine ammonia-lyase
4.3.1.19 threonine ammonia-lyase



S-adenosyl-L-methionine + glycine <=> H+ + S-adenosyl-L-homocysteine + sarcosine 2.1.1.156 glycine/sarcosine N-methyltransferase
2.1.1.162 glycine/sarcosine/dimethylglycine N-methyltransferase
2.1.1.20 glycine N-methyltransferase



glycine + H2O + O2 <=> glyoxylate + NH3 + H2O2 1.4.3.19 glycine oxidase
1.4.3.2 L-amino-acid oxidase
1.4.3.3 D-amino-acid oxidase



H2O + 3-phospho-D-glycerate <=> D-glycerate + phosphate 3.1.3.10 glucose-1-phosphatase
3.1.3.19 glycerol-2-phosphatase
3.1.3.2 acid phosphatase
3.1.3.20 phosphoglycerate phosphatase
3.1.3.26 4-phytase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.38 3-phosphoglycerate phosphatase
3.1.3.58 sugar-terminal-phosphatase
3.1.3.60 phosphoenolpyruvate phosphatase
3.1.3.8 3-phytase










L-serine <=> D-serine 4.3.1.17 L-serine ammonia-lyase
5.1.1.1 alanine racemase
5.1.1.10 amino-acid racemase
5.1.1.18 serine racemase




2-phospho-D-glycerate <=> 3-phospho-D-glycerate 5.4.2.11 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)
5.4.2.12 phosphoglycerate mutase (2,3-diphosphoglycerate-independent)


choline + NADP+ <=> Betaine_aldehyde + NADPH + H+ 1.1.1
1.1.1.1 alcohol dehydrogenase


D-glycerate + ATP <=> H+ + 3-phospho-D-glycerate + ADP 2.7.1.165 glycerate 2-kinase
2.7.1.31 glycerate 3-kinase


D-glycerate + ATP <=> H+ + 2-phospho-D-glycerate + ADP 2.7.1.165 glycerate 2-kinase

L-aspartate + ATP <=> L-4-aspartyl_phosphate + ADP 2.7.2.4 aspartate kinase

glyoxylate + L-serine <=> Hydroxypyruvate + glycine 2.6.1.15 glutamine---pyruvate transaminase
2.6.1.35 glycine---oxaloacetate transaminase
2.6.1.4 glycine transaminase
2.6.1.44 alanine---glyoxylate transaminase
2.6.1.45 serine---glyoxylate transaminase
2.6.1.51 serine---pyruvate transaminase
2.6.1.60 aromatic-amino-acid---glyoxylate transaminase







D-glycerate + NADP+ <=> Hydroxypyruvate + NADPH + H+ 1.1.1
1.1.1.215 gluconate 2-dehydrogenase
1.1.1.27 L-lactate dehydrogenase
1.1.1.60 2-hydroxy-3-oxopropionate reductase
1.1.1.79 glyoxylate reductase (NADP+)
1.1.1.81 hydroxypyruvate reductase
1.1.1.86 ketol-acid reductoisomerase (NADP+)
1.1.1.92 oxaloglycolate reductase (decarboxylating)








choline + NAD+ <=> Betaine_aldehyde + NADH + H+ 1.1.1
1.1.1.1 alcohol dehydrogenase


L-allo-threonine + NADP+ <=> L-2-amino-3-oxobutanoate + NADPH + H+ 1.1.1.276 serine 3-dehydrogenase (NADP+)
1.1.1.381 3-hydroxy acid dehydrogenase


S-adenosyl-L-methionine + Guanidinoacetate <=> H+ + S-adenosyl-L-homocysteine + Creatine 2.1.1.2 guanidinoacetate N-methyltransferase

L-cysteine + H2O <=> L-serine + Sulfide 2.5.1.47 cysteine synthase
2.5.1.49 O-acetylhomoserine aminocarboxypropyltransferase
4.2.1.22 cystathionine beta-synthase



L-cystathionine + H2O <=> L-cysteine + 2-oxobutyrate + NH3 2.5.1.48 cystathionine gamma-synthase
4.4.1.1 cystathionine gamma-lyase


L-threonine + NAD+ <=> L-2-amino-3-oxobutanoate + NADH + H+ 1.1.1.103 L-threonine 3-dehydrogenase

choline + acceptor <=> Betaine_aldehyde + reduced_acceptor 1.1.99.1 choline dehydrogenase

D-serine <=> pyruvate + NH3 4.3.1.15 diaminopropionate ammonia-lyase
4.3.1.18 D-serine ammonia-lyase


N4-acetyl-L-2,4-diaminobutanoate <=> L-ectoine + H2O 4.2.1.108 ectoine synthase

S-adenosyl-L-methionine + N,N-dimethylglycine <=> H+ + S-adenosyl-L-homocysteine + betaine 2.1.1.157 sarcosine/dimethylglycine N-methyltransferase
2.1.1.161 dimethylglycine N-methyltransferase
2.1.1.162 glycine/sarcosine/dimethylglycine N-methyltransferase



S-adenosyl-L-methionine + sarcosine <=> S-adenosyl-L-homocysteine + betaine + H+ 2.1.1.157 sarcosine/dimethylglycine N-methyltransferase

Betaine_aldehyde + NADP+ + H2O <=> betaine + NADPH 1.2.1.19 aminobutyraldehyde dehydrogenase
1.2.1.8 betaine-aldehyde dehydrogenase


L-2,4-diaminobutanoate + 2-oxoglutarate <=> L-aspartate_4-semialdehyde + L-glutamate 2.6.1.46 diaminobutyrate---pyruvate transaminase
2.6.1.76 diaminobutyrate---2-oxoglutarate transaminase
4.1.1.86 diaminobutyrate decarboxylase



L-serine + L-homocysteine <=> L-cystathionine + H2O 2.5.1.47 cysteine synthase
4.2.1.22 cystathionine beta-synthase


Betaine_aldehyde + O2 + H2O <=> betaine + H2O2 + H+ 1.1.3.17 choline oxidase
1.1.99.1 choline dehydrogenase


D-serine + 2-amino-5-guanidinovalerate <=> D-lombricine + L-ornithine not assigned

D-glycerate + NAD+ <=> H+ + Hydroxypyruvate + NADH 1.1.1.237 hydroxyphenylpyruvate reductase
1.1.1.26 glyoxylate reductase
1.1.1.27 L-lactate dehydrogenase
1.1.1.28 D-lactate dehydrogenase
1.1.1.29 glycerate dehydrogenase
1.1.1.387 L-serine 3-dehydrogenase (NAD+)
1.1.1.60 2-hydroxy-3-oxopropionate reductase
1.1.1.79 glyoxylate reductase (NADP+)
1.1.1.81 hydroxypyruvate reductase
1.1.1.92 oxaloglycolate reductase (decarboxylating)










O-phospho-L-homoserine + H2O <=> phosphate + L-threonine 4.2.3.1 threonine synthase

CDP-diacylglycerol + L-serine <=> CMP + phosphatidylserine + H+ 2.7.8.38 archaetidylserine synthase
2.7.8.8 CDP-diacylglycerol---serine O-phosphatidyltransferase


aminoacetone + H2O + O2 <=> methylglyoxal + NH3 + H2O2 1.4.3.21 primary-amine oxidase
1.4.3.4 monoamine oxidase


enzyme_N6-(dihydrolipoyl)lysine + NAD+ <=> [2-oxoglutarate_dehydrogenase_E2_protein]_N6-lipoyl-L-lysine + NADH + H+ 1.8.1.4 dihydrolipoyl dehydrogenase

glycine + H2O + 2 ferricytochrome_c <=> glyoxylate + NH3 + 2 ferricytochrome_c + 2 H+ 1.4.2.1 glycine dehydrogenase (cytochrome)

glycine + [dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]-lipoyllysine <=> S-aminomethyldihydrolipoylprotein + CO2 1.4.4.2 glycine dehydrogenase (aminomethyl-transferring)

sarcosine + H2O + flavin <=> glycine + formaldehyde + reduced_flavodoxin 1.5.8.3 sarcosine dehydrogenase

L-arginine + glycine <=> L-ornithine + Guanidinoacetate 2.1.4.1 glycine amidinotransferase

DL-threonine <=> acetaldehyde + glycine 2.1.2.1 glycine hydroxymethyltransferase
4.1.2
4.1.2.26 phenylserine aldolase
4.1.2.48 low-specificity L-threonine aldolase
4.1.2.49 L-allo-threonine aldolase
4.1.3.14 L-erythro-3-hydroxyaspartate aldolase






N,N-dimethylglycine + O2 + H2O <=> H2O2 + formaldehyde + sarcosine 1.5.3.10 dimethylglycine oxidase

L-ectoine + 2-oxoglutarate + O2 <=> 5-hydroxyectoine + succinate + CO2 1.14.11.55 ectoine hydroxylase

D-lombricine + ATP <=> H+ + Nomega-phospho-D-lombricine + ADP 2.7.3.4 taurocyamine kinase
2.7.3.5 lombricine kinase


L-homocysteine + betaine <=> L-methionine + N,N-dimethylglycine 2.1.1.5 betaine---homocysteine S-methyltransferase

O-phospho-L-serine + 2-oxoglutarate <=> L-glutamate + 3-phosphohydroxypyruvate 2.6.1.52 phosphoserine transaminase

choline + O2 <=> Betaine_aldehyde + H2O2 1.1.3.17 choline oxidase

pyruvate + L-serine <=> L-alanine + Hydroxypyruvate 2.6.1.44 alanine---glyoxylate transaminase
2.6.1.45 serine---glyoxylate transaminase
2.6.1.51 serine---pyruvate transaminase
2.6.1.64 glutamine---phenylpyruvate transaminase
2.6.1.B16





L-homoserine + NADP+ <=> L-aspartate_4-semialdehyde + NADPH + H+ 1.1.1.3 homoserine dehydrogenase

L-aspartate_4-semialdehyde + NAD+ + H2O <=> L-aspartate + NADH + H+ 1.2.1
1.2.1.M5


L-homoserine + NAD+ <=> L-aspartate_4-semialdehyde + NADH + H+ 1.1.1.3 homoserine dehydrogenase

O-phospho-L-serine + H2O <=> L-serine + phosphate 3.1.3.1 alkaline phosphatase
3.1.3.15 histidinol-phosphatase
3.1.3.16 protein-serine/threonine phosphatase
3.1.3.2 acid phosphatase
3.1.3.20 phosphoglycerate phosphatase
3.1.3.26 4-phytase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.3 phosphoserine phosphatase
3.1.3.48 protein-tyrosine-phosphatase
3.1.3.75 phosphoethanolamine/phosphocholine phosphatase
3.1.3.8 3-phytase











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