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Biosynthesis of type II polyketide backbone

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
18-Carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[acp] + NADPH + H+ <=> C-9_Reduced_nonaketamide + NADP+ 1.1.1

8 malonyl-CoA + [acyl-carrier_protein] <=> 3,5,7,9,11,13,15-Heptaoxo-hexadecanoyl-[acp] + 8 CO2 + 8 CoA 2.3.1

7,9,12-Decaketide_intermediate_4 + NADPH + H+ <=> 7,9,12-Decaketide_intermediate_5 + NADP+ 1.1.1

10 malonyl-CoA + [acyl-carrier_protein] <=> 3,5,7,9,11,13,15,17,19-Nonaoxo-eicosanoyl-[acp] + 10 CO2 + 10 CoA 2.3.1
2.3.1.235 tetracenomycin F2 synthase


3,5,7,9,11,13,15,17,19-Nonaoxo-eicosanoyl-[acp] <=> 7,12-Decaketide_intermediate_1 + H2O 4.2.1

3,5,7,9,11,13,15,17,19-Nonaoxo-eicosanoyl-[acp] <=> 9,14-Decaketide_intermediate_1 + 2 H2O 2.3.1.235 tetracenomycin F2 synthase
4.2.1


7,9,12-Octaketide_intermediate_1 + NADPH + H+ <=> 7,9,12-Octaketide_intermediate_2 + NADP+ 1.1.1

butyryl-CoA + 9 malonyl-CoA + [acyl-carrier_protein] <=> 3,5,7,9,11,13,15,17,19-Nonaoxo-docosanoyl-[acp] + 9 CO2 + 9 CoA 2.3.1

3,5,7,9,11,13,15-Heptaoxo-hexadecanoyl-[acp] <=> 7,9,12-Octaketide_intermediate_1 not assigned

Malonamoyl-[acyl-carrier_protein] + 8 malonyl-CoA <=> 18-Carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[acp] + 8 CO2 + 8 CoA 2.3.1.260 tetracycline polyketide synthase

7,9,12-Decaketide_intermediate_2 <=> 7,9,12-Decaketide_intermediate_3 + 2 H2O 4.2.1

7,9,12-Decaketide_intermediate_5 <=> 7,9,12-Decaketide_intermediate_6 + 2 H2O 4.2.1

propionyl-CoA + 9 malonyl-CoA + [acyl-carrier_protein] <=> 3,5,7,9,11,13,15,17,19-nonaoxohenicosanoyl-[acp] + 9 CO2 + 9 CoA 2.3.1

C-9_Reduced_nonaketamide <=> Nonaketamide_monocyclic_intermediate + 2 H2O 4.2.1

3,5,7,9,11,13,15,17,19-nonaoxohenicosanoyl-[acp] <=> 7,9,12-Decaketide_intermediate_4 not assigned

butyryl-CoA + 7 malonyl-CoA + [acyl-carrier_protein] <=> 3,5,7,9,11,13,15-Heptaoxo-octadecanoyl-[acp] + 7 CO2 + 7 CoA 2.3.1

3,5,7,9,11,13,15,17,19-Nonaoxo-eicosanoyl-[acp] <=> 7,9,12-Decaketide_intermediate_1 not assigned

acetyl-CoA + 7 malonyl-CoA + [acyl-carrier_protein] <=> 3,5,7,9,11,13,15-Heptaoxo-hexadecanoyl-[acp] + 7 CO2 + 7 CoA 2.3.1

7,9,12-Octaketide_intermediate_2 <=> 7,9,12-Octaketide_intermediate_3 + 2 H2O 4.2.1

7,9,12-Decaketide_intermediate_1 + NADPH + H+ <=> 7,9,12-Decaketide_intermediate_2 + NADP+ 1.1.1

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