Copied!

Pathway Search

Please choose a pathway from the list:


Biosynthesis of amino acids

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
prephenate + NAD+ <=> 4-hydroxyphenylpyruvate + CO2 + NADH 1.3.1.12 prephenate dehydrogenase
1.3.1.13 prephenate dehydrogenase (NADP+)
1.3.1.79 arogenate dehydrogenase [NAD(P)+]



indole-3-glycerol_phosphate + L-serine <=> L-tryptophan + H2O + D-glyceraldehyde_3-phosphate 4.2.1.20 tryptophan synthase

argininosuccinate <=> L-arginine + fumarate 4.3.2.1 argininosuccinate lyase
4.3.2.2 adenylosuccinate lyase


L-serine <=> pyruvate + NH3 4.1.99.1 tryptophanase
4.1.99.2 tyrosine phenol-lyase
4.2.1.22 cystathionine beta-synthase
4.3.1.15 diaminopropionate ammonia-lyase
4.3.1.17 L-serine ammonia-lyase
4.3.1.18 D-serine ammonia-lyase
4.3.1.19 threonine ammonia-lyase







L-glutamate + N2-Acetyl-L-ornithine <=> N-acetyl-L-glutamate + L-ornithine 2.3.1.35 glutamate N-acetyltransferase

L-ornithine <=> L-proline + NH3 4.3.1.12 ornithine cyclodeaminase

N2-Acetyl-L-ornithine + 2-oxoglutarate <=> L-glutamate + N-acetyl-L-glutamate_5-semialdehyde 2.6.1.11 acetylornithine transaminase
2.6.1.13 ornithine aminotransferase


LysW-gamma-L-lysine + H2O <=> L-lysine + [LysW]-C-terminal-L-glutamate 3.5.1.130 [amino group carrier protein]-lysine hydrolase

D-fructose_1,6-bisphosphate <=> dihydroxyacetone_phosphate + D-glyceraldehyde_3-phosphate 4.1.2.13 fructose-bisphosphate aldolase
4.1.2.40 tagatose-bisphosphate aldolase


L-aspartate_4-semialdehyde + phosphate + NADP+ <=> L-4-aspartyl_phosphate + NADPH + H+ 1.2.1.11 aspartate-semialdehyde dehydrogenase

1-(5-phosphoribosyl)-AMP + H2O <=> N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide_ribonucleotide 3.5.4.19 phosphoribosyl-AMP cyclohydrolase

(2R,3S)-3-isopropylmalate + NAD+ <=> 4-methyl-2-oxopentanoate + CO2 + NADH 1.1.1.286 isocitrate---homoisocitrate dehydrogenase
1.1.1.85 3-isopropylmalate dehydrogenase


5-methyltetrahydropteroyl-gamma-glutamyl-gamma-glutamylglutamate + L-homocysteine <=> tetrahydropteroyl-Glu3 + L-methionine 2.1.1.13 methionine synthase
2.1.1.14 5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase


S-sulfocysteine + thioredoxin <=> L-cysteine + sulfite + thioredoxin_disulfide not assigned

homoisocitrate <=> (Z)-but-1-ene-1,2,4-tricarboxylate + H2O 4.2.1.114 methanogen homoaconitase
4.2.1.36 homoaconitate hydratase


chorismate + L-glutamine <=> H+ + anthranilate + L-glutamate + pyruvate 4.1.3.27 anthranilate synthase

5-enolpyruvylshikimate_3-phosphate <=> phosphate + chorismate 4.2.3.5 chorismate synthase

2-oxoisovalerate + acetyl-CoA + H2O <=> H+ + (2S)-2-isopropylmalate + CoA 2.3.3.13 2-isopropylmalate synthase
2.3.3.17 methylthioalkylmalate synthase


D-arabino-hex-3-ulose_6-phosphate <=> D-ribulose_5-phosphate + formaldehyde 4.1.2.43 3-hexulose-6-phosphate synthase

[amino_group_carrier_protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + 2-oxoglutarate <=> L-glutamate + LysW-L-glutamate_5-semialdehyde 2.6.1
2.6.1.11 acetylornithine transaminase


shikimate + NADP+ <=> 3-dehydroshikimate + NADPH + H+ 1.1.1.24 quinate dehydrogenase
1.1.1.25 shikimate dehydrogenase
1.1.1.282 quinate/shikimate dehydrogenase



L-valine + 2-oxoglutarate <=> L-glutamate + 2-oxoisovalerate 2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.6 leucine transaminase
2.6.1.66 valine---pyruvate transaminase




meso-2,6-diaminoheptanedioate + NADP+ + H2O <=> L-2-amino-6-oxopimelate + NH3 + NADPH + H+ 1.4.1.16 diaminopimelate dehydrogenase

L-homoserine + succinyl-CoA <=> O-succinyl-L-homoserine + CoA 2.3.1.46 homoserine O-succinyltransferase

saccharopine + H2O + NAD+ <=> 2-oxoglutarate + L-lysine + NADH + H+ 1.5.1.7 saccharopine dehydrogenase (NAD+, L-lysine-forming)
1.5.1.8 saccharopine dehydrogenase (NADP+, L-lysine-forming)


pyruvate + L-aspartate_4-semialdehyde <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O + H+ 4.3.3.7 4-hydroxy-tetrahydrodipicolinate synthase

LysW-gamma-L-alpha-aminoadipyl_6-phosphate + NADPH + H+ <=> LysW-gamma-L-alpha-aminoadipate_6-semialdehyde + NADP+ + phosphate 1.2.1.103

N2-Acetyl-L-ornithine + H2O <=> L-ornithine + acetate 2.3.1.35 glutamate N-acetyltransferase
3.5.1.14 N-acyl-aliphatic-L-amino acid amidohydrolase
3.5.1.16 acetylornithine deacetylase
3.5.1.17 acyl-lysine deacylase
3.5.1.B4





S-adenosyl-L-homocysteine + H2O <=> S-ribosylhomocysteine + adenine 3.2.2.16 methylthioadenosine nucleosidase
3.2.2.30 aminodeoxyfutalosine nucleosidase
3.2.2.9 adenosylhomocysteine nucleosidase



H+ + H2O + L-pyrroline-5-carboxylate <=> L-glutamate_5-semialdehyde 0.0.0.0

L-aspartate + NH3 + ATP <=> H+ + L-asparagine + diphosphate + AMP 6.3.1.1 aspartate---ammonia ligase
6.3.5.4 asparagine synthase (glutamine-hydrolysing)


citraconate + H2O <=> D-erythro-3-Methylmalate 4.2.1.35 (R)-2-methylmalate dehydratase

L-2,4-diaminobutanoate + 2-oxoglutarate <=> L-aspartate_4-semialdehyde + L-glutamate 2.6.1.46 diaminobutyrate---pyruvate transaminase
2.6.1.76 diaminobutyrate---2-oxoglutarate transaminase
4.1.1.86 diaminobutyrate decarboxylase



(R)-citramalate <=> citraconate + H2O 4.2.1.31 maleate hydratase
4.2.1.35 (R)-2-methylmalate dehydratase


(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP+ <=> L-2-aminoadipate + ATP + NADPH + H+ 1.2.1.95 L-2-aminoadipate reductase

L-Histidinol_phosphate + 2-oxoglutarate <=> 3-(Imidazol-4-yl)-2-oxopropyl_phosphate + L-glutamate 2.6.1.9 histidinol-phosphate transaminase

3-deoxy-D-arabino-hept-2-ulosonate_7-phosphate <=> 3-dehydroquinate + phosphate 4.2.1.10 3-dehydroquinate dehydratase
4.2.3.4 3-dehydroquinate synthase


H+ + 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate <=> indole-3-glycerol_phosphate + CO2 + H2O 4.1.1.48 indole-3-glycerol-phosphate synthase

L-glutamate + NADP+ <=> H+ + L-glutamine + 2-oxoglutarate + NADPH 1.4.1.13 glutamate synthase (NADPH)
1.4.1.B5


acetyl-CoA + pyruvate + H2O <=> H+ + (R)-citramalate + CoA 2.3.1.182 (R)-citramalate synthase
2.3.3.13 2-isopropylmalate synthase


(2R,3S)-3-isopropylmalate <=> (2S)-2-isopropylmalate 4.2.1.33 3-isopropylmalate dehydratase

O-phospho-L-serine + 2-oxoglutarate <=> L-glutamate + 3-phosphohydroxypyruvate 2.6.1.52 phosphoserine transaminase

L-aspartate + L-citrulline + ATP <=> H+ + argininosuccinate + diphosphate + AMP 6.3.4.5 argininosuccinate synthase

2R,3R-2,3-dihydroxy-3-methylpentanoate + NADP+ <=> (R)-3-hydroxy-3-methyl-2-oxopentanoate + NADPH + H+ 1.1.1.86 ketol-acid reductoisomerase (NADP+)

L-phenylalanine + tetrahydrobiopterin + O2 <=> L-tyrosine + dihydrobiopterin + H2O 1.14.16.1 phenylalanine 4-monooxygenase
1.14.16.4 tryptophan 5-monooxygenase


L-Histidinol_phosphate + H2O <=> L-Histidinol + phosphate 3.1.3.15 histidinol-phosphatase
3.1.3.2 acid phosphatase


L-Histidinol + NAD+ + H2O <=> L-histidine + NADH + H+ 1.1.1.23 histidinol dehydrogenase

citrate <=> isocitrate 4.2.1.3 aconitate hydratase

H2O + N-acetyl-L,L-2,6-diaminopimelate <=> LL-2,6-Diaminoheptanedioate + acetate 3.5.1.47 N-acetyldiaminopimelate deacetylase

[amino_group_carrier_protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O <=> L-ornithine + [LysW]-C-terminal-L-glutamate 3.5.1.132 [amino group carrier protein]-ornithine hydrolase

LysW-gamma-L-alpha-aminoadipate_6-semialdehyde + L-glutamate <=> LysW-gamma-L-lysine + 2-oxoglutarate 2.6.1.118

O-acetyl-L-serine + L-homocysteine <=> L-cystathionine + acetate + H+ 2.5.1.134 cystathionine beta-synthase (O-acetyl-L-serine)
2.5.1.47 cysteine synthase
4.2.1.22 cystathionine beta-synthase



L-threonine <=> glycine + acetaldehyde 4.1.2.26 phenylserine aldolase
4.1.2.42 D-threonine aldolase
4.1.2.48 low-specificity L-threonine aldolase
4.1.2.5 L-threonine aldolase




L-threonine <=> 2-oxobutyrate + NH3 4.2.3.1 threonine synthase
4.3.1.17 L-serine ammonia-lyase
4.3.1.19 threonine ammonia-lyase



homocitrate <=> homoisocitrate 4.2.1.114 methanogen homoaconitase

H2O + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + succinyl-CoA <=> N-succinyl-L-2-amino-6-oxoheptanedioate + CoA 2.3.1.117 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

D-glyceraldehyde_3-phosphate + phosphate + NADP+ <=> 3-phospho-D-glyceroyl_phosphate + NADPH + H+ 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
1.2.1.13 glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)
1.2.1.59 glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating)
1.2.1.9 glyceraldehyde-3-phosphate dehydrogenase (NADP+)




L-ornithine + Carbamoyl_phosphate <=> H+ + L-citrulline + phosphate 2.1.3.3 ornithine carbamoyltransferase
2.1.3.6 putrescine carbamoyltransferase
3.5.3.12 agmatine deiminase



D-ribose_5-phosphate <=> D-ribulose_5-phosphate 5.3.1.6 ribose-5-phosphate isomerase

L-proline + NADP+ <=> L-pyrroline-5-carboxylate + NADPH + H+ 1.5.1.2 pyrroline-5-carboxylate reductase

LysW-L-glutamyl_5-phosphate + NADPH + H+ <=> LysW-L-glutamate_5-semialdehyde + NADP+ + phosphate 1.2.1

2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O 4.2.1.11 phosphopyruvate hydratase

L-cystathionine + H2O <=> L-cysteine + 2-oxobutyrate + NH3 2.5.1.48 cystathionine gamma-synthase
4.4.1.1 cystathionine gamma-lyase


sedoheptulose_7-phosphate + D-glyceraldehyde_3-phosphate <=> D-ribose_5-phosphate + D-xylulose_5-phosphate 2.2.1.1 transketolase
2.2.1.3 formaldehyde transketolase


(R)-2,3-dihydroxy-3-methylbutanoate <=> 2-oxoisovalerate + H2O 4.2.1.9 dihydroxy-acid dehydratase

LL-2,6-Diaminoheptanedioate + 2-oxoglutarate <=> (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O + H+ 2.6.1.83 LL-diaminopimelate aminotransferase

L-isoleucine + 2-oxoglutarate <=> L-glutamate + (S)-3-methyl-2-oxopentanoate 2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.67 2-aminohexanoate transaminase


D-arabino-hex-3-ulose_6-phosphate <=> beta-D-fructose_6-phosphate 5.3.1.27 6-phospho-3-hexuloisomerase

N2-Acetyl-L-ornithine + Carbamoyl_phosphate <=> H+ + N-acetyl-L-citrulline + phosphate 2.1.3.11 N-succinylornithine carbamoyltransferase
2.1.3.9 N-acetylornithine carbamoyltransferase


2-oxoglutarate + L-alanine <=> L-glutamate + pyruvate 2.6.1.1 aspartate transaminase
2.6.1.12 alanine---oxo-acid transaminase
2.6.1.2 alanine transaminase
2.6.1.37 2-aminoethylphosphonate---pyruvate transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.4 glycine transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.5 tyrosine transaminase
2.6.1.79 glutamate---prephenate aminotransferase









(S)-2-Hydroxy-2-methyl-3-oxobutanoate <=> 3-hydroxy-3-methyl-2-oxobutanoic_acid 1.1.1.86 ketol-acid reductoisomerase (NADP+)
5.4.99.3 2-acetolactate mutase


L-N-acetyl-2-amino-6-oxopimelate + L-glutamate <=> N-acetyl-L,L-2,6-diaminopimelate + 2-oxoglutarate 2.6.1

D-glyceraldehyde_3-phosphate + phosphate + NAD+ <=> 3-phospho-D-glyceroyl_phosphate + NADH + H+ 1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
1.2.1.13 glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)
1.2.1.59 glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating)
1.2.1.9 glyceraldehyde-3-phosphate dehydrogenase (NADP+)




L-glutamate + [LysW]-C-terminal-L-glutamate + ATP <=> LysW-L-glutamate + ADP + phosphate 6.3.2

isocitrate + NADP+ <=> 2-oxoglutarate + CO2 + NADPH 1.1.1.286 isocitrate---homoisocitrate dehydrogenase
1.1.1.41 isocitrate dehydrogenase (NAD+)
1.1.1.42 isocitrate dehydrogenase (NADP+)



H+ + pyruvate + 2-oxobutyrate <=> (S)-2-hydroxy-2-ethyl-3-oxobutanoate + CO2 2.2.1.6 acetolactate synthase

phosphoenolpyruvate + D-erythrose_4-phosphate + H2O <=> 3-deoxy-D-arabino-hept-2-ulosonate_7-phosphate + phosphate 2.5.1.54 3-deoxy-7-phosphoheptulonate synthase
2.5.1.55 3-deoxy-8-phosphooctulonate synthase


L-homoserine + NADP+ <=> L-aspartate_4-semialdehyde + NADPH + H+ 1.1.1.3 homoserine dehydrogenase

L-arogenate + NADP+ <=> L-tyrosine + CO2 + NADPH 1.3.1.43 arogenate dehydrogenase
1.3.1.78 arogenate dehydrogenase (NADP+)
1.3.1.79 arogenate dehydrogenase [NAD(P)+]



H+ + pyruvate <=> (S)-2-Hydroxy-2-methyl-3-oxobutanoate + CO2 2.2.1.6 acetolactate synthase
4.1.1.1 pyruvate decarboxylase


N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate <=> anthranilate + 5-phospho-alpha-D-ribose_1-diphosphate 2.4.2.18 anthranilate phosphoribosyltransferase

H2O + N-succinyl-LL-2,6-diaminoheptanedioate <=> LL-2,6-Diaminoheptanedioate + succinate 3.5.1.18 succinyl-diaminopimelate desuccinylase

H+ + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O <=> L-2-amino-6-oxopimelate 0.0.0.0
3.5.99


D-glyceraldehyde_3-phosphate + H2O + oxidized_ferredoxin <=> 3-phospho-D-glycerate + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.2.7.6 glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)

pyruvate + HCO3- + ATP <=> H+ + oxaloacetate + ADP + phosphate 6.4.1.1 pyruvate carboxylase

L-serine + tetrahydrofolate <=> glycine + 5,10-methylenetetrahydrofolate + H2O 2.1.2.1 glycine hydroxymethyltransferase

homoisocitrate + NAD+ <=> 2-oxoadipate + CO2 + NADH 1.1.1.286 isocitrate---homoisocitrate dehydrogenase
1.1.1.42 isocitrate dehydrogenase (NADP+)
1.1.1.87 homoisocitrate dehydrogenase



L-serine + acetyl-CoA <=> O-acetyl-L-serine + CoA 2.3.1.30 serine O-acetyltransferase

D-ribose_5-phosphate + ATP <=> H+ + 5-phospho-alpha-D-ribose_1-diphosphate + AMP 2.7.6.1 ribose-phosphate diphosphokinase

D-ribulose_5-phosphate <=> D-xylulose_5-phosphate 5.1.3.1 ribulose-phosphate 3-epimerase
5.3.1.34 D-erythrulose 4-phosphate isomerase


L-glutamine + L-aspartate + ATP + H2O <=> H+ + L-glutamate + L-asparagine + diphosphate + AMP 6.3.5.4 asparagine synthase (glutamine-hydrolysing)

(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NADP+ + H2O <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADPH + H+ 1.17.1.8 4-hydroxy-tetrahydrodipicolinate reductase

D-erythro-1-(imidazol-4-yl)glycerol_3-phosphate <=> 3-(Imidazol-4-yl)-2-oxopropyl_phosphate + H2O 4.2.1.19 imidazoleglycerol-phosphate dehydratase

chorismate + NH3 <=> anthranilate + pyruvate + H2O 4.1.3.27 anthranilate synthase

L-leucine + 2-oxoglutarate <=> L-glutamate + 4-methyl-2-oxopentanoate 2.6.1.1 aspartate transaminase
2.6.1.2 alanine transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.6 leucine transaminase
2.6.1.67 2-aminohexanoate transaminase
2.6.1.9 histidinol-phosphate transaminase








D-erythrose_4-phosphate + D-xylulose_5-phosphate <=> beta-D-fructose_6-phosphate + D-glyceraldehyde_3-phosphate 2.2.1.1 transketolase
2.2.1.3 formaldehyde transketolase


ATP + L-methionine + H2O <=> S-adenosyl-L-methionine + phosphate + diphosphate 2.5.1.6 methionine adenosyltransferase

O-acetyl-L-serine + thiosulfate <=> H+ + S-sulfocysteine + acetate 2.5.1.144 S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent)
2.5.1.47 cysteine synthase


O-succinyl-L-homoserine + L-cysteine <=> L-cystathionine + succinate + H+ 2.5.1.48 cystathionine gamma-synthase

phosphoribulosylformimino-AICAR-phosphate + L-glutamine <=> H+ + L-glutamate + D-erythro-1-(imidazol-4-yl)glycerol_3-phosphate + 5-aminoimidazole-4-carboxamide_ribonucleotide 4.3.1.B2
4.3.2.10 imidazole glycerol-phosphate synthase


(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD+ + H2O <=> (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NADH + H+ 1.17.1.8 4-hydroxy-tetrahydrodipicolinate reductase

S-adenosyl-L-methionine <=> S-adenosyl-L-homocysteine 2.1.1

L-homocysteine + 5-methyltetrahydrofolate <=> L-methionine + tetrahydrofolate 2.1.1.13 methionine synthase
2.1.1.14 5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase


L-tyrosine + 2-oxoglutarate <=> 4-hydroxyphenylpyruvate + L-glutamate 2.6.1.1 aspartate transaminase
2.6.1.2 alanine transaminase
2.6.1.24 diiodotyrosine transaminase
2.6.1.27 tryptophan transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.49 dihydroxyphenylalanine transaminase
2.6.1.5 tyrosine transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase
2.6.1.79 glutamate---prephenate aminotransferase
2.6.1.9 histidinol-phosphate transaminase












2-oxoglutarate + H2O + acetyl-CoA <=> H+ + homocitrate + CoA 2.3.3.14 homocitrate synthase

2-oxoglutarate + N-succinyl-LL-2,6-diaminoheptanedioate <=> L-glutamate + N-succinyl-L-2-amino-6-oxoheptanedioate 2.6.1.17 succinyldiaminopimelate transaminase

L-serine + L-homocysteine <=> L-cystathionine + H2O 2.5.1.47 cysteine synthase
4.2.1.22 cystathionine beta-synthase


H2O + L-arginine <=> Urea + L-ornithine 3.5.3.1 arginase
3.5.3.7 guanidinobutyrase


acetyl-CoA + H2O + oxaloacetate <=> citrate + CoA + H+ 2.3.3.1 citrate (Si)-synthase
2.3.3.14 homocitrate synthase
2.3.3.16 citrate synthase (unknown stereospecificity)
2.3.3.3 citrate (Re)-synthase




L-aspartate + 2-oxoglutarate <=> oxaloacetate + L-glutamate 2.6.1.1 aspartate transaminase
2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.2 alanine transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.5 tyrosine transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.75 cysteine-conjugate transaminase
2.6.1.78 aspartate---prephenate aminotransferase
2.6.1.79 glutamate---prephenate aminotransferase










H+ + prephenate <=> phenylpyruvate + H2O + CO2 4.2.1.51 prephenate dehydratase
4.2.1.91 arogenate dehydratase


meso-2,6-diaminoheptanedioate + H+ <=> L-lysine + CO2 4.1.1.20 diaminopimelate decarboxylase

L-cystathionine + H2O <=> L-homocysteine + pyruvate + NH3 2.5.1.48 cystathionine gamma-synthase
3.5.1.61 mimosinase
4.2.1.22 cystathionine beta-synthase
4.4.1.1 cystathionine gamma-lyase
4.4.1.13 cysteine-S-conjugate beta-lyase
4.4.1.28 L-cysteine desulfidase
4.4.1.3 dimethylpropiothetin dethiomethylase







N-acetyl-L-citrulline + H2O <=> L-citrulline + acetate 3.5.1.16 acetylornithine deacetylase
3.5.1.B4


LysW-L-glutamate + ATP <=> LysW-L-glutamyl_5-phosphate + ADP 2.7.2

L-2-aminoadipate + 2-oxoglutarate <=> L-glutamate + 2-oxoadipate 2.6.1.39 2-aminoadipate transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase


L-glutamate + acetyl-CoA <=> H+ + N-acetyl-L-glutamate + CoA 2.3.1.1 amino-acid N-acetyltransferase
2.3.1.17 aspartate N-acetyltransferase
2.3.1.183 phosphinothricin acetyltransferase
2.7.2.8 acetylglutamate kinase
6.3.4.16 carbamoyl-phosphate synthase (ammonia)





L-homoserine + NAD+ <=> L-aspartate_4-semialdehyde + NADH + H+ 1.1.1.3 homoserine dehydrogenase

L-proline + NAD+ <=> L-pyrroline-5-carboxylate + NADH + H+ 1.2.1.88 L-glutamate gamma-semialdehyde dehydrogenase
1.5.1.2 pyrroline-5-carboxylate reductase
1.5.5.2 proline dehydrogenase



O-phospho-L-serine + H2O <=> L-serine + phosphate 3.1.3.1 alkaline phosphatase
3.1.3.15 histidinol-phosphatase
3.1.3.16 protein-serine/threonine phosphatase
3.1.3.2 acid phosphatase
3.1.3.20 phosphoglycerate phosphatase
3.1.3.26 4-phytase
3.1.3.29 N-acylneuraminate-9-phosphatase
3.1.3.3 phosphoserine phosphatase
3.1.3.48 protein-tyrosine-phosphatase
3.1.3.75 phosphoethanolamine/phosphocholine phosphatase
3.1.3.8 3-phytase











chorismate <=> prephenate 5.4.99.5 chorismate mutase

N'-[(5'-phosphoribosyl)formimino]-5-aminoimidazole-4-carboxamide_ribonucleotide <=> phosphoribulosylformimino-AICAR-phosphate 5.3.1.16 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase

L-homoserine + ATP <=> H+ + O-phospho-L-homoserine + ADP 2.7.1.39 homoserine kinase

N-acetyl-L-glutamate + ATP <=> N-acetyl-L-glutamyl_5-phosphate + ADP 2.7.2.8 acetylglutamate kinase

3-phospho-D-glycerate + ATP <=> 3-phospho-D-glyceroyl_phosphate + ADP 2.7.2.10 phosphoglycerate kinase (GTP)
2.7.2.3 phosphoglycerate kinase


3-phospho-D-glycerate + NAD+ <=> H+ + 3-phosphohydroxypyruvate + NADH 1.1.1.95 phosphoglycerate dehydrogenase

shikimate + ATP <=> H+ + 3-phosphoshikimate + ADP 2.7.1.71 shikimate kinase

ATP + NH3 + CO2 + H2O <=> ADP + phosphate + Carbamoyl_phosphate 6.3.4.16 carbamoyl-phosphate synthase (ammonia)
6.3.5.5 carbamoyl-phosphate synthase (glutamine-hydrolysing)


(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ <=> 3-hydroxy-3-methyl-2-oxobutanoic_acid + NADPH + H+ 1.1.1.86 ketol-acid reductoisomerase (NADP+)

(S)-2-hydroxy-2-ethyl-3-oxobutanoate <=> (R)-3-hydroxy-3-methyl-2-oxopentanoate 1.1.1.86 ketol-acid reductoisomerase (NADP+)
5.4.99.3 2-acetolactate mutase


O-acetyl-L-serine + Sulfide <=> L-cysteine + acetate + H+ 2.5.1.47 cysteine synthase
2.5.1.49 O-acetylhomoserine aminocarboxypropyltransferase
2.5.1.65 O-phosphoserine sulfhydrylase
4.2.1.22 cystathionine beta-synthase
4.2.1.50 pyrazolylalanine synthase
4.4.1.9 L-3-cyanoalanine synthase






L-aspartate + H+ <=> L-alanine + CO2 4.1.1.12 aspartate 4-decarboxylase
4.4.1.1 cystathionine gamma-lyase


sedoheptulose_7-phosphate + D-glyceraldehyde_3-phosphate <=> beta-D-fructose_6-phosphate + D-erythrose_4-phosphate 2.2.1.1 transketolase
2.2.1.2 transaldolase


NH3 + L-glutamate + ATP <=> H+ + L-glutamine + ADP + phosphate 6.3.1.2 glutamine synthetase

2-phospho-D-glycerate <=> 3-phospho-D-glycerate 5.4.2.11 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)
5.4.2.12 phosphoglycerate mutase (2,3-diphosphoglycerate-independent)


L-arogenate + 2-oxoglutarate <=> prephenate + L-glutamate 2.6.1.1 aspartate transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.78 aspartate---prephenate aminotransferase
2.6.1.79 glutamate---prephenate aminotransferase




[LysW]-C-terminal-gamma-(L-2-aminoadip-2-yl)-L-glutamate54 + ATP <=> LysW-gamma-L-alpha-aminoadipyl_6-phosphate + ADP 2.7.2.17

L-aspartate + ATP <=> L-4-aspartyl_phosphate + ADP 2.7.2.4 aspartate kinase

S-ribosylhomocysteine <=> L-homocysteine + (S)-4,5-dihydroxypentan-2,3-dione 4.4.1.21 S-ribosylhomocysteine lyase

N-1-(5'-phosphoribosyl)-ATP + H2O <=> 1-(5-phosphoribosyl)-AMP + diphosphate + H+ 3.6.1.31 phosphoribosyl-ATP diphosphatase