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3-hydroxypropanoate cycle

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
succinyl-CoA + (S)-malate <=> succinate + (3S)-3-carboxy-3-hydroxypropanoyl-CoA 2.8.3.18 succinyl-CoA:acetate CoA-transferase
2.8.3.22 succinyl-CoA---L-malate CoA-transferase


(R)-2-methylmalonyl-CoA <=> succinyl-CoA 5.4.99.2 methylmalonyl-CoA mutase
5.4.99.63 ethylmalonyl-CoA mutase
5.4.99.64 2-hydroxyisobutanoyl-CoA mutase



malonate_semialdehyde + CoA + NADP+ <=> malonyl-CoA + NADPH + H+ 1.2.1.18 malonate-semialdehyde dehydrogenase (acetylating)
1.2.1.75 malonyl-CoA reductase (malonate semialdehyde-forming)


acetyl-CoA + [carboxyl-carrier_protein_dimer]-N6-carboxybiotinyl-L-lysine <=> malonyl-CoA + [biotin_carboxyl-carrier-protein_dimer]-N6-biotinyl-L-lysine 2.1.3.15 acetyl-CoA carboxytransferase

ATP + propionyl-CoA + HCO3- <=> H+ + (S)-methylmalonyl-CoA + phosphate + ADP 6.4.1.2 acetyl-CoA carboxylase
6.4.1.3 propionyl-CoA carboxylase


HCO3- <=> H2O + CO2 1.6.5.4 monodehydroascorbate reductase (NADH)
4.2.1.1 carbonic anhydrase


[biotin_carboxyl-carrier-protein_dimer]-N6-biotinyl-L-lysine + HCO3- + ATP <=> phosphate + [carboxyl-carrier_protein_dimer]-N6-carboxybiotinyl-L-lysine + ADP + H+ 6.3.4.14 biotin carboxylase

(3S)-3-carboxy-3-hydroxypropanoyl-CoA <=> glyoxylate + acetyl-CoA 4.1.3.24 malyl-CoA lyase

(R)-2-methylmalonyl-CoA <=> (S)-methylmalonyl-CoA 5.1.99.1 methylmalonyl-CoA epimerase

propionyl-CoA + NADP+ <=> acryloyl-CoA + NADPH + H+ 1.3.1
1.3.1.84 acrylyl-CoA reductase (NADPH)
1.3.1.95 acrylyl-CoA reductase (NADH)



3-hydroxypropionate + ATP + CoA <=> bithionol + AMP + diphosphate 6.2.1.17 propionate---CoA ligase
6.2.1.36 3-hydroxypropionyl-CoA synthase
6.2.1.40 4-hydroxybutyrate---CoA ligase (AMP-forming)



bithionol <=> acryloyl-CoA + H2O 4.2.1
4.2.1.116 3-hydroxypropionyl-CoA dehydratase
4.2.1.17 enoyl-CoA hydratase



3-hydroxypropionate + NADP+ <=> malonate_semialdehyde + NADPH + H+ 1.1.1
1.1.1.2 alcohol dehydrogenase (NADP+)
1.1.1.276 serine 3-dehydrogenase (NADP+)
1.1.1.298 3-hydroxypropionate dehydrogenase (NADP+)




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