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(S)-lactate fermentation to propanoate, acetate and hydrogen

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
(R)-2-methylmalonyl-CoA <=> succinyl-CoA 5.4.99.2 methylmalonyl-CoA mutase
5.4.99.63 ethylmalonyl-CoA mutase
5.4.99.64 2-hydroxyisobutanoyl-CoA mutase



menaquinol + fumarate <=> menaquinone + succinate 1.3.5.1 succinate dehydrogenase
1.3.5.4 fumarate reductase (quinol)


formate + acetyl-CoA <=> pyruvate + CoA 2.3.1.54 formate C-acetyltransferase

ATP + acetate <=> ADP + acetyl_phosphate 2.1.2.2 phosphoribosylglycinamide formyltransferase
2.7.2.1 acetate kinase
2.7.2.15 propionate kinase
2.7.2.2 carbamate kinase




L-lactate + NAD+ <=> pyruvate + NADH + H+ 1.1.1.27 L-lactate dehydrogenase
1.1.1.28 D-lactate dehydrogenase
1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.37 malate dehydrogenase
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating)






(S)-methylmalonyl-CoA + H+ + Na+ <=> CO2 + propionyl-CoA + Na+ 7.2.4.3 (S)-methylmalonyl-CoA decarboxylase (sodium-transporting)

pyruvate + HCO3- + ATP <=> H+ + oxaloacetate + ADP + phosphate 6.4.1.1 pyruvate carboxylase

(R)-2-methylmalonyl-CoA <=> (S)-methylmalonyl-CoA 5.1.99.1 methylmalonyl-CoA epimerase

(S)-malate + NAD+ <=> oxaloacetate + NADH + H+ 1.1.1.27 L-lactate dehydrogenase
1.1.1.28 D-lactate dehydrogenase
1.1.1.299 malate dehydrogenase [NAD(P)+]
1.1.1.337 L-2-hydroxycarboxylate dehydrogenase (NAD+)
1.1.1.37 malate dehydrogenase
1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]
1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating)
1.1.1.81 hydroxypyruvate reductase
1.1.1.82 malate dehydrogenase (NADP+)
1.1.1.85 3-isopropylmalate dehydrogenase
1.1.1.95 phosphoglycerate dehydrogenase
1.1.1.96 diiodophenylpyruvate reductase












(S)-malate <=> fumarate + H2O 4.2.1.2 fumarate hydratase
4.2.1.34 (S)-2-methylmalate dehydratase


phosphate + acetyl-CoA <=> acetyl_phosphate + CoA 2.3.1.19 phosphate butyryltransferase
2.3.1.222 phosphate propanoyltransferase
2.3.1.8 phosphate acetyltransferase



propionyl-CoA + succinate <=> propionate + succinyl-CoA 2.8.3
2.8.3.1 propionate CoA-transferase
2.8.3.18 succinyl-CoA:acetate CoA-transferase
2.8.3.M4




H+ + formate <=> CO2 + H2 not assigned

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