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2-Oxocarboxylic acid metabolism

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
2-isopropylmaleate + H2O <=> (2S)-2-isopropylmalate 4.2.1.33 3-isopropylmalate dehydratase

L-glutamate + N2-Acetyl-L-ornithine <=> N-acetyl-L-glutamate + L-ornithine 2.3.1.35 glutamate N-acetyltransferase

2-[(2''-methylsulfanyl)ethyl]malate <=> 3-[(2''-methylsulfanyl)ethyl]malate 4.2.1.170 2-(omega-methylthio)alkylmalate dehydratase

L-homophenylalanine + 2 O2 + 2 NADPH + 2 H+ <=> 3-Phenylpropionaldoxim + 2 NADP+ + CO2 + 3 H2O 1.14.13

L-trihomomethionine + 2 reduced_flavodoxin + 2 O2 <=> 6-Methylthiohexanaldoxime + 2 flavin + CO2 + 3 H2O 1.14.14.42 homomethionine N-monooxygenase

N2-Acetyl-L-ornithine + 2-oxoglutarate <=> L-glutamate + N-acetyl-L-glutamate_5-semialdehyde 2.6.1.11 acetylornithine transaminase
2.6.1.13 ornithine aminotransferase


3-[(5''-methylsulfanyl)pentyl]malate + NAD+ <=> 8-methylthio-2-oxooctanoate + CO2 + NADH 1.1.1
1.1.1.85 3-isopropylmalate dehydrogenase


2-[(7''-methylsulfanyl)heptyl]malate <=> 3-[(7''-methylsulfanyl)heptyl]malate 4.2.1.170 2-(omega-methylthio)alkylmalate dehydratase

LysW-gamma-L-lysine + H2O <=> L-lysine + [LysW]-C-terminal-L-glutamate 3.5.1.130 [amino group carrier protein]-lysine hydrolase

L-aspartate_4-semialdehyde + phosphate + NADP+ <=> L-4-aspartyl_phosphate + NADPH + H+ 1.2.1.11 aspartate-semialdehyde dehydrogenase

(2R,3S)-3-isopropylmalate + NAD+ <=> 4-methyl-2-oxopentanoate + CO2 + NADH 1.1.1.286 isocitrate---homoisocitrate dehydrogenase
1.1.1.85 3-isopropylmalate dehydrogenase


homoisocitrate <=> (Z)-but-1-ene-1,2,4-tricarboxylate + H2O 4.2.1.114 methanogen homoaconitase
4.2.1.36 homoaconitate hydratase


2-[(3''-methylsulfanyl)propyl]malate <=> 3-[(3''-methylsulfanyl)propyl]malate 4.2.1.170 2-(omega-methylthio)alkylmalate dehydratase

2-oxoisovalerate + acetyl-CoA + H2O <=> H+ + (2S)-2-isopropylmalate + CoA 2.3.3.13 2-isopropylmalate synthase
2.3.3.17 methylthioalkylmalate synthase


trihomocitrate <=> (-)-threo-iso(homo)3citrate 4.2.1.114 methanogen homoaconitase

[amino_group_carrier_protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + 2-oxoglutarate <=> L-glutamate + LysW-L-glutamate_5-semialdehyde 2.6.1
2.6.1.11 acetylornithine transaminase


9-methylthio-2-oxononanoate + acetyl-CoA + H2O <=> H+ + 2-[(7''-methylsulfanyl)heptyl]malate + CoA 2.3.3.17 methylthioalkylmalate synthase

(E,Z)-indolyl-3-acetaldoxime + L-cysteine + NADPH + O2 + H+ <=> S-(Indolylmethylthiohydroximoyl)-L-cysteine + NADP+ + 2 H2O 1.14.14.43 (methylsulfanyl)alkanaldoxime N-monooxygenase
1.14.14.45 aromatic aldoxime N-monooxygenase


3-[(7''-methylsulfanyl)heptyl]malate + NAD+ <=> 2-Oxo-10-methylthiodecanoate + CO2 + NADH 1.1.1
1.1.1.85 3-isopropylmalate dehydrogenase


L-valine + 2-oxoglutarate <=> L-glutamate + 2-oxoisovalerate 2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.6 leucine transaminase
2.6.1.66 valine---pyruvate transaminase




(-)-threo-iso(homo)3citrate + NAD+ <=> 2-Oxosuberate + CO2 + NADH 1.1.1

2-Oxo-8-methylthiooctanoic_acid + an_L-amino_acid <=> L-tetrahomomethionine + a_2-oxo_carboxylate 2.6.1

2-Benzylmalate <=> 3-Benzylmalate 4.2.1

isocitrate + NADP+ <=> oxalosuccinate + NADPH + H+ 1.1.1.42 isocitrate dehydrogenase (NADP+)

L-homomethionine + 2 flavin_hydroquinone + 2 O2 <=> an_omega-(methylthio)-(E)-alkanal_oxime + 2 [oxidized_NADPH-hemoprotein_reductase] + CO2 + 3 H2O 1.14.14.42 homomethionine N-monooxygenase

LysW-gamma-L-alpha-aminoadipyl_6-phosphate + NADPH + H+ <=> LysW-gamma-L-alpha-aminoadipate_6-semialdehyde + NADP+ + phosphate 1.2.1.103

N2-Acetyl-L-ornithine + H2O <=> L-ornithine + acetate 2.3.1.35 glutamate N-acetyltransferase
3.5.1.14 N-acyl-aliphatic-L-amino acid amidohydrolase
3.5.1.16 acetylornithine deacetylase
3.5.1.17 acyl-lysine deacylase
3.5.1.B4





L-2,4-diaminobutanoate + 2-oxoglutarate <=> L-aspartate_4-semialdehyde + L-glutamate 2.6.1.46 diaminobutyrate---pyruvate transaminase
2.6.1.76 diaminobutyrate---2-oxoglutarate transaminase
4.1.1.86 diaminobutyrate decarboxylase



2-Oxo-9-methylthiononanoic_acid + an_L-amino_acid <=> L-pentahomomethionine + a_2-oxo_carboxylate 2.6.1

citraconate + H2O <=> D-erythro-3-Methylmalate 4.2.1.35 (R)-2-methylmalate dehydratase

dihomocitrate <=> (Z)-pent-1-ene-1,2,5-tricarboxylate + H2O 4.2.1.114 methanogen homoaconitase

(R)-citramalate <=> citraconate + H2O 4.2.1.31 maleate hydratase
4.2.1.35 (R)-2-methylmalate dehydratase


2-oxo-4-phenylbutanoic_acid + an_L-amino_acid <=> L-homophenylalanine + a_2-oxo_carboxylate 2.6.1

acetyl-CoA + pyruvate + H2O <=> H+ + (R)-citramalate + CoA 2.3.1.182 (R)-citramalate synthase
2.3.3.13 2-isopropylmalate synthase


(2R,3S)-3-isopropylmalate <=> (2S)-2-isopropylmalate 4.2.1.33 3-isopropylmalate dehydratase

2R,3R-2,3-dihydroxy-3-methylpentanoate + NADP+ <=> (R)-3-hydroxy-3-methyl-2-oxopentanoate + NADPH + H+ 1.1.1.86 ketol-acid reductoisomerase (NADP+)

4-methylthiobutanaldoxime + L-cysteine + reduced_flavodoxin + O2 <=> S-(4-Methylthiobutylthiohydroximoyl)-L-cysteine + flavin + 2 H2O 1.14.14.43 (methylsulfanyl)alkanaldoxime N-monooxygenase

trihomocitrate <=> (Z)-hex-1-ene-1,2,6-tricarboxylate + H2O 4.2.1.114 methanogen homoaconitase

2-Oxo-10-methylthiodecanoic_acid + an_L-amino_acid <=> L-hexahomomethionine + a_2-oxo_carboxylate 2.6.1

citrate <=> isocitrate 4.2.1.3 aconitate hydratase

3-Benzylmalate + NAD+ <=> 2-oxo-4-phenylbutanoic_acid + CO2 + NADH 1.1.1

[amino_group_carrier_protein]-C-terminal-gamma-(L-ornithyl)-L-glutamate + H2O <=> L-ornithine + [LysW]-C-terminal-L-glutamate 3.5.1.132 [amino group carrier protein]-ornithine hydrolase

LysW-gamma-L-alpha-aminoadipate_6-semialdehyde + L-glutamate <=> LysW-gamma-L-lysine + 2-oxoglutarate 2.6.1.118

UDP-glucose + p-Hydroxyphenylacetothiohydroximate <=> desulfo-p-hydroxy-benzylglucosinolate + UDP 2.4.1.195 N-hydroxythioamide S-beta-glucosyltransferase

L-valine + 2 flavin_hydroquinone + 2 O2 <=> (E/Z)-isobutyraldoxime + 2 [oxidized_NADPH-hemoprotein_reductase] + CO2 + 3 H2O 1.14.14.38 valine N-monooxygenase

Oxaloglutarate <=> 2-oxoadipate + CO2 1.1.1.286 isocitrate---homoisocitrate dehydrogenase
1.1.1.87 homoisocitrate dehydrogenase


UDP-glucose + 2-(3-indolyl)acetothiohydroximate <=> desulfo-indol-3-yl-methyl_glucosinolate + UDP 2.4.1.195 N-hydroxythioamide S-beta-glucosyltransferase

(Z)-hex-1-ene-1,2,6-tricarboxylate + H2O <=> (-)-threo-iso(homo)3citrate 4.2.1.114 methanogen homoaconitase

p-hydroxyphenylacetaldoxime + L-cysteine + NADPH + O2 + H+ <=> S-(Hydroxyphenylacetothiohydroximoyl)-L-cysteine + NADP+ + 2 H2O 1.14.14.45 aromatic aldoxime N-monooxygenase

homocitrate <=> homoisocitrate 4.2.1.114 methanogen homoaconitase

3''-phosphoadenylyl-sulfate + desulfo-indol-3-yl-methyl_glucosinolate <=> adenosine_3,5''-bisphosphate + glucobrassicin + H+ 2.8.2.24 aromatic desulfoglucosinolate sulfotransferase
2.8.2.38 aliphatic desulfoglucosinolate sulfotransferase


3-[(3''-methylsulfanyl)propyl]malate + NAD+ <=> 6-methylthio-2-oxohexanoate + CO2 + NADH 1.1.1
1.1.1.85 3-isopropylmalate dehydrogenase


S-(4-Methylthiobutylthiohydroximoyl)-L-cysteine + H2O <=> an_(E)-omega-(methylthio)alkyl-thiohydroximate + pyruvate + NH3 4.4.1
4.4.1.13 cysteine-S-conjugate beta-lyase


3-[(4''-methylsulfanyl)butyl]malate + NAD+ <=> 7-methylthio-2-oxoheptanoate + CO2 + NADH 1.1.1
1.1.1.85 3-isopropylmalate dehydrogenase


LysW-L-glutamyl_5-phosphate + NADPH + H+ <=> LysW-L-glutamate_5-semialdehyde + NADP+ + phosphate 1.2.1

(R)-2,3-dihydroxy-3-methylbutanoate <=> 2-oxoisovalerate + H2O 4.2.1.9 dihydroxy-acid dehydratase

H+ + trihomocitrate + CoA <=> 2-oxopimelic_acid + acetyl-CoA + H2O 2.3.3
4.1.3


L-isoleucine + 2-oxoglutarate <=> L-glutamate + (S)-3-methyl-2-oxopentanoate 2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.67 2-aminohexanoate transaminase


2-Oxo-5-methylthiopentanoic_acid + an_L-amino_acid <=> L-homomethionine + a_2-oxo_carboxylate 2.6.1

L-hexahomomethionine + 2 O2 + 2 flavin_hydroquinone <=> 4-methylthiononanaldoxime + CO2 + 3 H2O + 2 [oxidized_NADPH-hemoprotein_reductase] 1.14.14.42 homomethionine N-monooxygenase

S-(Hydroxyphenylacetothiohydroximoyl)-L-cysteine + H2O <=> p-Hydroxyphenylacetothiohydroximate + pyruvate + NH3 + H+ 4.4.1
4.4.1.13 cysteine-S-conjugate beta-lyase


6-methylthio-2-oxohexanoate + acetyl-CoA + H2O <=> H+ + 2-[(4''-methylsulfanyl)butyl]malate + CoA 2.3.3.17 methylthioalkylmalate synthase

2-oxoglutarate + L-alanine <=> L-glutamate + pyruvate 2.6.1.1 aspartate transaminase
2.6.1.12 alanine---oxo-acid transaminase
2.6.1.2 alanine transaminase
2.6.1.37 2-aminoethylphosphonate---pyruvate transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.4 glycine transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.5 tyrosine transaminase
2.6.1.79 glutamate---prephenate aminotransferase









(S)-2-Hydroxy-2-methyl-3-oxobutanoate <=> 3-hydroxy-3-methyl-2-oxobutanoic_acid 1.1.1.86 ketol-acid reductoisomerase (NADP+)
5.4.99.3 2-acetolactate mutase


L-phenylalanine + a_2-oxo_carboxylate <=> phenylpyruvate + an_L-amino_acid 2.6.1

L-tetrahomomethionine + 2 O2 + 2 flavin_hydroquinone <=> 4-methylthioheptanaldoxime + CO2 + 3 H2O + 2 [oxidized_NADPH-hemoprotein_reductase] 1.14.14.42 homomethionine N-monooxygenase

L-glutamate + [LysW]-C-terminal-L-glutamate + ATP <=> LysW-L-glutamate + ADP + phosphate 6.3.2

isocitrate + NADP+ <=> 2-oxoglutarate + CO2 + NADPH 1.1.1.286 isocitrate---homoisocitrate dehydrogenase
1.1.1.41 isocitrate dehydrogenase (NAD+)
1.1.1.42 isocitrate dehydrogenase (NADP+)



H+ + pyruvate + 2-oxobutyrate <=> (S)-2-hydroxy-2-ethyl-3-oxobutanoate + CO2 2.2.1.6 acetolactate synthase

H+ + pyruvate <=> (S)-2-Hydroxy-2-methyl-3-oxobutanoate + CO2 2.2.1.6 acetolactate synthase
4.1.1.1 pyruvate decarboxylase


3''-phosphoadenylyl-sulfate + desulfo-p-hydroxy-benzylglucosinolate <=> adenosine_3,5''-bisphosphate + p-hydroxybenzylglucosinolate + H+ 2.8.2
2.8.2.24 aromatic desulfoglucosinolate sulfotransferase


7-methylthio-2-oxoheptanoate + acetyl-CoA + H2O <=> H+ + 2-[(5''-methylsulfanyl)pentyl]malate + CoA 2.3.3.17 methylthioalkylmalate synthase

homoisocitrate + NAD+ <=> 2-oxoadipate + CO2 + NADH 1.1.1.286 isocitrate---homoisocitrate dehydrogenase
1.1.1.42 isocitrate dehydrogenase (NADP+)
1.1.1.87 homoisocitrate dehydrogenase



2-isopropylmaleate + H2O <=> (2S)-2-isopropylmalate 4.2.1.33 3-isopropylmalate dehydratase

2-[(4''-methylsulfanyl)butyl]malate <=> 3-[(4''-methylsulfanyl)butyl]malate 4.2.1.170 2-(omega-methylthio)alkylmalate dehydratase

UDP-glucose + an_(E)-omega-(methylthio)alkyl-thiohydroximate <=> H+ + an_aliphatic_desulfoglucosinolate + UDP 2.4.1.195 N-hydroxythioamide S-beta-glucosyltransferase

8-methylthio-2-oxooctanoate + acetyl-CoA + H2O <=> H+ + 2-[(6''-methylsulfanyl)hexyl]malate + CoA 2.3.3.17 methylthioalkylmalate synthase

3''-phosphoadenylyl-sulfate + an_aliphatic_desulfoglucosinolate <=> adenosine_3,5''-bisphosphate + H+ + glucoiberverin 2.8.2
2.8.2.38 aliphatic desulfoglucosinolate sulfotransferase


homoisocitrate + NAD+ <=> Oxaloglutarate + NADH + H+ 1.1.1.286 isocitrate---homoisocitrate dehydrogenase
1.1.1.87 homoisocitrate dehydrogenase


L-leucine + 2-oxoglutarate <=> L-glutamate + 4-methyl-2-oxopentanoate 2.6.1.1 aspartate transaminase
2.6.1.2 alanine transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.6 leucine transaminase
2.6.1.67 2-aminohexanoate transaminase
2.6.1.9 histidinol-phosphate transaminase








(2R,3S)-3-isopropylmalate + NAD+ <=> (2S)-2-isopropyl-3-oxosuccinate + NADH + H+ 1.1.1.85 3-isopropylmalate dehydrogenase

2-[(6''-methylsulfanyl)hexyl]malate <=> 3-[(6''-methylsulfanyl)hexyl]malate 4.2.1.170 2-(omega-methylthio)alkylmalate dehydratase

S-(Phenylacetothiohydroximoyl)-L-cysteine + H2O <=> phenylacetothiohydroximate + pyruvate + NH3 + H+ 4.4.1
4.4.1.13 cysteine-S-conjugate beta-lyase


(E)-phenylacetaldoxime + L-cysteine + NADPH + O2 + H+ <=> S-(Phenylacetothiohydroximoyl)-L-cysteine + NADP+ + 2 H2O 1.14.14.45 aromatic aldoxime N-monooxygenase

L-tyrosine + 2 O2 + 2 flavin_hydroquinone <=> p-hydroxyphenylacetaldoxime + 2 [oxidized_NADPH-hemoprotein_reductase] + CO2 + 3 H2O 1.14.14.36 tyrosine N-monooxygenase
1.14.14.40 phenylalanine N-monooxygenase


L-tyrosine + 2-oxoglutarate <=> 4-hydroxyphenylpyruvate + L-glutamate 2.6.1.1 aspartate transaminase
2.6.1.2 alanine transaminase
2.6.1.24 diiodotyrosine transaminase
2.6.1.27 tryptophan transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.49 dihydroxyphenylalanine transaminase
2.6.1.5 tyrosine transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase
2.6.1.79 glutamate---prephenate aminotransferase
2.6.1.9 histidinol-phosphate transaminase












2-[(5''-methylsulfanyl)pentyl]malate <=> 3-[(5''-methylsulfanyl)pentyl]malate 4.2.1.170 2-(omega-methylthio)alkylmalate dehydratase

2-oxoglutarate + H2O + acetyl-CoA <=> H+ + homocitrate + CoA 2.3.3.14 homocitrate synthase

acetyl-CoA + H2O + oxaloacetate <=> citrate + CoA + H+ 2.3.3.1 citrate (Si)-synthase
2.3.3.14 homocitrate synthase
2.3.3.16 citrate synthase (unknown stereospecificity)
2.3.3.3 citrate (Re)-synthase




L-aspartate + 2-oxoglutarate <=> oxaloacetate + L-glutamate 2.6.1.1 aspartate transaminase
2.6.1.19 4-aminobutyrate---2-oxoglutarate transaminase
2.6.1.2 alanine transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.5 tyrosine transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.75 cysteine-conjugate transaminase
2.6.1.78 aspartate---prephenate aminotransferase
2.6.1.79 glutamate---prephenate aminotransferase










L-phenylalanine + 2 flavin_hydroquinone + 2 O2 <=> (E)-phenylacetaldoxime + 2 [oxidized_NADPH-hemoprotein_reductase] + CO2 + 3 H2O 1.14.14.40 phenylalanine N-monooxygenase

3''-phosphoadenylyl-sulfate + desulfo-4-methylthiobutylglucosinolate <=> adenosine_3,5''-bisphosphate + H+ + glucoerucin 2.8.2
2.8.2.38 aliphatic desulfoglucosinolate sulfotransferase


dihomocitrate <=> (-)-threo-iso(homo)2citrate 4.2.1.114 methanogen homoaconitase

LysW-L-glutamate + ATP <=> LysW-L-glutamyl_5-phosphate + ADP 2.7.2

L-2-aminoadipate + 2-oxoglutarate <=> L-glutamate + 2-oxoadipate 2.6.1.39 2-aminoadipate transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase


5-methylthio-2-oxopentanoate + acetyl-CoA + H2O <=> H+ + 2-[(3''-methylsulfanyl)propyl]malate + CoA 2.3.3.17 methylthioalkylmalate synthase

L-glutamate + acetyl-CoA <=> H+ + N-acetyl-L-glutamate + CoA 2.3.1.1 amino-acid N-acetyltransferase
2.3.1.17 aspartate N-acetyltransferase
2.3.1.183 phosphinothricin acetyltransferase
2.7.2.8 acetylglutamate kinase
6.3.4.16 carbamoyl-phosphate synthase (ammonia)





L-methionine + a_2-oxo_carboxylate <=> 4-methylsulfanyl-2-oxobutanoate + an_aliphatic_L-amino_acid 2.6.1.88 methionine transaminase

L-isoleucine + 2 flavin_hydroquinone + 2 O2 <=> (1E,2S)-2-methylbutanal_oxime + 2 [oxidized_NADPH-hemoprotein_reductase] + CO2 + 3 H2O 1.14.14.39 isoleucine N-monooxygenase

cis-aconitate + H2O <=> isocitrate 4.2.1.3 aconitate hydratase

N-acetyl-L-glutamate + ATP <=> N-acetyl-L-glutamyl_5-phosphate + ADP 2.7.2.8 acetylglutamate kinase

4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O <=> 2-[(2''-methylsulfanyl)ethyl]malate + CoA + H+ 2.3.3.17 methylthioalkylmalate synthase

L-tryptophan + 2 flavin_hydroquinone + 2 O2 <=> (E,Z)-indolyl-3-acetaldoxime + 2 [oxidized_NADPH-hemoprotein_reductase] + CO2 + 3 H2O 1.14.14.156 tryptophan N-monooxygenase

UDP-glucose + phenylacetothiohydroximate <=> desulfoglucotropaeolin + UDP 2.4.1.195 N-hydroxythioamide S-beta-glucosyltransferase

citrate <=> cis-aconitate + H2O 4.2.1.117 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)
4.2.1.3 aconitate hydratase


dihomocitrate + CoA + H+ <=> 2-oxoadipate + acetyl-CoA + H2O 2.3.3
4.1.3


S-(Indolylmethylthiohydroximoyl)-L-cysteine + H2O <=> 2-(3-indolyl)acetothiohydroximate + pyruvate + NH3 4.4.1

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ <=> 3-hydroxy-3-methyl-2-oxobutanoic_acid + NADPH + H+ 1.1.1.86 ketol-acid reductoisomerase (NADP+)

(S)-2-hydroxy-2-ethyl-3-oxobutanoate <=> (R)-3-hydroxy-3-methyl-2-oxopentanoate 1.1.1.86 ketol-acid reductoisomerase (NADP+)
5.4.99.3 2-acetolactate mutase


3-[(6''-methylsulfanyl)hexyl]malate + NAD+ <=> 9-methylthio-2-oxononanoate + CO2 + NADH 1.1.1
1.1.1.85 3-isopropylmalate dehydrogenase


L-leucine + 2 O2 + 2 NADPH + 2 H+ <=> (E/Z)-isovaleraldoxime + 3 H2O + 2 NADP+ + CO2 1.14.13

[LysW]-C-terminal-gamma-(L-2-aminoadip-2-yl)-L-glutamate54 + ATP <=> LysW-gamma-L-alpha-aminoadipyl_6-phosphate + ADP 2.7.2.17

L-aspartate + ATP <=> L-4-aspartyl_phosphate + ADP 2.7.2.4 aspartate kinase

(Z)-pent-1-ene-1,2,5-tricarboxylate + H2O <=> (-)-threo-iso(homo)2citrate 4.2.1.114 methanogen homoaconitase

phenylpyruvate + acetyl-CoA + H2O <=> 2-Benzylmalate + CoA + H+ 2.3.3

(-)-threo-iso(homo)2citrate + NAD+ <=> 2-oxopimelic_acid + CO2 + NADH 1.1.1

2-Oxo-7-methylthioheptanoic_acid + an_L-amino_acid <=> L-trihomomethionine + a_2-oxo_carboxylate 2.6.1

H+ + (2S)-2-isopropyl-3-oxosuccinate <=> 4-methyl-2-oxopentanoate + CO2 0.0.0.0
1.1.1.85 3-isopropylmalate dehydrogenase


D-erythro-3-Methylmalate + NAD+ <=> 2-oxobutyrate + CO2 + NADH 1.1.1
1.1.1.85 3-isopropylmalate dehydrogenase


L-dihomomethionine + 2 O2 + 2 flavin_hydroquinone <=> omega-(methylthio)-(E)-alkanal_oxime + CO2 + 3 H2O + 2 [oxidized_NADPH-hemoprotein_reductase] 1.14.14.42 homomethionine N-monooxygenase

oxalosuccinate + H+ <=> 2-oxoglutarate + CO2 1.1.1.42 isocitrate dehydrogenase (NADP+)

isocitrate + NAD+ <=> 2-oxoglutarate + CO2 + NADH 1.1.1.286 isocitrate---homoisocitrate dehydrogenase
1.1.1.41 isocitrate dehydrogenase (NAD+)
1.1.1.42 isocitrate dehydrogenase (NADP+)
1.1.1.87 homoisocitrate dehydrogenase




L-phenylalanine + 2-oxoglutarate <=> phenylpyruvate + L-glutamate 2.6.1.1 aspartate transaminase
2.6.1.24 diiodotyrosine transaminase
2.6.1.27 tryptophan transaminase
2.6.1.39 2-aminoadipate transaminase
2.6.1.42 branched-chain-amino-acid transaminase
2.6.1.5 tyrosine transaminase
2.6.1.57 aromatic-amino-acid transaminase
2.6.1.60 aromatic-amino-acid---glyoxylate transaminase
2.6.1.64 glutamine---phenylpyruvate transaminase
2.6.1.7 kynurenine---oxoglutarate transaminase
2.6.1.70 aspartate---phenylpyruvate transaminase
2.6.1.79 glutamate---prephenate aminotransferase
2.6.1.9 histidinol-phosphate transaminase













L-pentahomomethionine + 2 O2 + 2 flavin_hydroquinone <=> 4-methylthiooctanaldoxime + CO2 + 3 H2O + 2 [oxidized_NADPH-hemoprotein_reductase] 1.14.14.42 homomethionine N-monooxygenase

3''-phosphoadenylyl-sulfate + desulfoglucotropaeolin <=> adenosine_3,5''-bisphosphate + benzylglucosinolate + H+ 2.8.2.24 aromatic desulfoglucosinolate sulfotransferase
2.8.2.38 aliphatic desulfoglucosinolate sulfotransferase


N-acetyl-L-glutamate_5-semialdehyde + NADP+ + phosphate <=> H+ + N-acetyl-L-glutamyl_5-phosphate + NADPH 1.2.1.38 N-acetyl-gamma-glutamyl-phosphate reductase

homocitrate <=> (Z)-but-1-ene-1,2,4-tricarboxylate + H2O 4.2.1
4.2.1.114 methanogen homoaconitase
4.2.1.36 homoaconitate hydratase



ATP + [LysW]-C-terminal-L-glutamate + L-2-aminoadipate <=> ADP + phosphate + [LysW]-C-terminal-gamma-(L-2-aminoadip-2-yl)-L-glutamate54 6.3.2.43 [lysine-biosynthesis-protein LysW]---L-2-aminoadipate ligase

3-(2''-Methylthio)ethylmalic_acid + NAD+ <=> 2-Oxo-5-methylthiopentanoic_acid + CO2 + NADH + H+ 1.1.1

2-Oxo-6-methylthiohexanoic_acid + an_L-amino_acid <=> L-dihomomethionine + a_2-oxo_carboxylate 2.6.1

2R,3R-2,3-dihydroxy-3-methylpentanoate <=> (S)-3-methyl-2-oxopentanoate + H2O 4.2.1.9 dihydroxy-acid dehydratase

Visualization of the pathway